Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 293 for “"mTOR"”.
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Investigation of mTOR-independent regulation of macroautophagy
Investigation of mTOR-independent regulation of macroautophagy Richard Ian Odle Macroautophagy is a critical catabolic response to cellular stress, enabling lysosomal mediated breakdown of cytosolic cargo. The nutrient-responsive mTORC1 kinase complex has been described as a master regulator of …
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Regulation of PPARgamma Activity by mTOR in Adipogenesis
… mechanism of mammalian target of rapamycin mTOR signaling, which involves cytoplasmic-nuclear shuttling of mTOR. As direct evidence, data show that leptomycin B (LMB), a specific inhibitor of nuclear export receptor Crm1 confers the accumulation of nuclear mTOR. Further investigation by …
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Daily organisation of cellular physiology by mTOR kinase
… the mechanistic target of rapamycin complex (mTORC) activity exhibits daily rhythms both in vivo and in cultured cells. Circadian rhythms are sensitive to changes in mTORC activity, moreover, many circadian-regulated process are directly or indirectly sensitive to changes in mTORC activity …
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Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
… to dysfunctional cell signaling. The PI3K/AKT/mTOR pathway is an important pro-growth intracellular signaling cascade that is often inappropriately activated in a wide array of cancers. Efforts to develop anticancer drugs have therefore focused, in part, on identifying PI3K/AKT/mTOR pathway …
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Regulation of peripheral nerve regeneration by the mTOR pathway
… of the mammalian target of rapamycin: mTOR) pathway. We find that PNS dorsal root ganglia neurons: DRGs) activate mTOR following damage, and that this activity contributes to enhance axonal growth capacity following injury. Furthermore, upregulation of mTOR activity by deletion of …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
… (BMPR2) and the mammalian target of rapamycin (mTOR) signaling pathways in the pathogenesis of PAH and asthma, respectively. Previous studies have indicated mutations in BMPR2 as one of the contributing factors in the pathogenesis of the heritable form of PAH. Although BMPR2 mutations have been …
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The role of mTOR signaling in Alzheimer s disease
… activity of the mammalian target of rapamycin (mTOR) increases lifespan and health-span in several genetically different species. mTOR is a ubiquitously expressed protein kinase that plays a key role in regulating protein synthesis and cell growth. mTOR also is a negative regulator of autophagy …
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mTOR Signaling in Cellular Growth and Skeletal Muscle Maturation
A Serine/Threonine kinase, mTOR, is a cellular target of rapamycin and plays a role in cellular growth and proliferation by regulating translation through the phosphorylation of 4E-BP1 and S6K. Here, I investigated the function of mTOR for the activation of newly found S6K1 homologue, S6K2, and for …
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Regulation of skeletal myogenesis by the mTOR signaling network
… expression. The mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that controls a wide spectrum of cellular and developmental processes including regulation of skeletal myogenesis. In my dissertation work, I investigate the mechanisms of myogenic regulation, with a focus on the signaling …
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Evaluation of the PI3K/Akt/mTOR pathway in Multiple Sclerosis
Background The PI3K/AKT/mTOR pathway is an intracellular signaling pathway that regulates cell activation. proliferation, metabolism and apoptosis. Increasing body of data suggests that alterations in the PI3K/AKT/mTOR pathway may result in an enhanced susceptibility to autoimmunity. Aim of our …
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Molecular Mechanism of Insulin Resistance: Role of mTOR Signaling Pathways
… Chapter IV, I describe another investigation of mTOR signaling mechanisms. In this study I initially set out to identify nuclear export signals in mTOR. A systematic scan of the mTOR sequence revealed 16 peptides conforming to the canonical leucine-rich nuclear export signal, of which 3 were …
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Mechanisms of mTOR Signal Transduction Regulating Cell Growth and Differentiation
… which is up-regulated during differentiation. mTOR is essential for miR-1 expression in C2C12 cells and in vivo in regenerating myofibers. It regulates the transcription of miR-1 through its upstream enhancers, and this regulation is at least partially mediated by the myogenic transcription …
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Regulation of the Lipid Kinase VPS34 by mTOR-Mediated UVRAG Phosphorylation
… regulated by the master growth protein kinase mTOR. This study sought to identify novel control mechanisms that may mediate the regulation of VPS34 between the pathways of endocytosis and autophagy. During nutrient rich conditions a binding protein of VPS34, UVRAG, was identified to be …
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Pi3K- and Mtor-Dependent Mechanisms of Lapatinib Resistance and Resulting Therapeutic Opportunities
… and/or upregulation. In a third LapR cell line, mTOR activation was enhanced in a manner independent of its usual PI3K/Akt-mediated activation or other known mTOR activators. Thus, all three cell lines possessed increased activation of the PI3K/mTOR pathway, suggesting the use of PI3K and/or mTOR …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… the heart is the mammalian target of rapamycin (mTOR), which couples energy and nutrient metabolism to cell growth. Recently, sustained mTOR activation has also been implicated in the development of endoplasmic reticulum (ER) stress. We explored possible mechanisms by which acute metabolic …
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Dual mTOR/HDAC Inhibition: Preclinical Development of a Novel Breast Cancer Therapy
… kinase Bmammalian target of rapamycin (PI3K/AKT/mTOR), despite effective upstream receptor inhibition. Activation of this pathway increases ribosome biogenesis and translation of oncogenic mRNAs, which are controlled by intracellular histone deacetylase (HDAC) activity as well. In fact, HDAC …
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AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication
… 증식을 위해서는 AMPK의 억제와mammalian target of rapamycin(mTOR)의 활성이 필요하며 이를 통해 바이러스 복제에 필요한 지질을 합성한다. HBV X 단백질(HBx)은 mTOR의 활성을 증가시켜 hepatocellular carcinoma(HCC) 세포의 증식을 유도한다. 본 연구에서는 HBV가 증식할 때 AMPK와 mTOR의 활성에 변화가 있는지 알아보았고, AMPK-mTOR 신호전달 과정의 변화가 HBV 증식에 영향을 미치는지 알아보고자 하였다. HCC 세포인 HepG2세포에서 유래한 HBV 가 …
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Regulation of mTOR complex 1 in response to growth factors and nutrients
… understand the regulation of mammalian TORC1 (mTORC1) by upstream signals. In the work described here, we identified PRAS40 as a new component of mTORC1. PRAS40 is phosphorylated in response to growth factors and this phosphorylation event leads to mTORC1 activation. We also showed that the …
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Characterization of mTOR Inhibition and Autophagy Inhibition in Non-Small Cell Lung Cancer
… has been to characterize NSCLC response to mTOR inhibition and determine whether there are any molecular biomarkers that can predict response. mTOR is a central regulator of several pro-oncogenic signaling pathways and plays a role in cell growth, proliferation, metabolism, and inhibition of …
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