Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"mTEC"”.
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Determination of Thymic Epithelial Cell Composition and Proliferation During The Perinatal to Adult Transition
… both cortical TEC (cTEC) and medullary TEC (mTEC) are expanded in the K5.D1 thymus, FACs analysis revealed a marked increase in a novel UEA-1<sup>int</sup> Sca-1- TEC subset, which is not readily classified as belonging to either the cTEC or mTEC lineage. In addition, low level expression of …
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The development and function of thymic microenvironments
… of various medullary thymic epithelial cell (mTEC) subsets has also been defined. Additionally, the importance of chemokine-mediated signalling for the establishment and compartmentalisation of the thymus has been highlighted by employing laser capture microdissection and studying thymus …
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Investigating lymphocyte development in the foetal thymus and modulation by the melanocortin 5 receptor
… vicinity of medullary thymic epithelial cells (mTEC). To provide greater molecular insight into this cellular niche, single-molecule RNA fluorescence in situ hybridisation (smFISH) was performed on E17.5 foetal thymus to visually identify gene expression of 100 genes with single-cell resolution. …
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Investigating factors governing cell fate decisions in respiratory epithelium
… explants and mouse tracheal epithelial cell (MTEC) cultures, I have also explored the regulation of cell fate decisions in distal human lung epithelium at the pseudoglandular stage of development. At this stage SOX9+ distal tip cells are self-renewing and multipotent and give rise to SOX2+ …
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Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
… interaction of cortical (cTEC) and medullary (mTEC) thymic epithelial cells (TEC) with migrating thymocytes is of fundamental importance in driving thymocyte differentiation and their selection towards generation of an immunocompetent but self-tolerant T cell repertoire. While the ontogeny, …
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Airway Epithelium Organotypic Culture Models as a Platform for Adverse Outcome Pathway Assessment of Engineered Nanomaterials
… derived from murine tracheal epithelial cells (MTEC) as a high-content in vitro model of the conducting airway to characterize Gà E effects, or in this case—the effects of genotype à phenotype interaction (Gà P), in order to identify determinants of sensitivity and help define both regulatory …
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The Treatment of Breast Cancer Tumor Growth and Metastasis With an Anti-MMP9 DNAzyme
… labeled mammary tumor epithelial cells (luc‑MTEC) isolated from MMTV‑PyMT mice and treating the animals with AM9D, control DNAzyme, or PBS for 3 weeks or up to 10 weeks, respectively.</p> <p>The mechanism of substrate specificity of 68 kDa MMP‑9 was determined by generating a series of …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… as well as a decline in mature Aire-expressing mTECs. Therefore, we explore the role of Wnt ligands potentially responsible for stimulating and/or regulating Wnt signaling in TECs by analyzing the genetic expression of various TEC populations in TCF/Lef:H2B/GFP Wnt reporter mice. Here we show …