Global ETD Search
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Showing 1 to 20 of 76 for “"mTBI"”.
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A Study of Resting State FMRI Dynamic Functional Network Analysis of MTBI
Mild Traumatic Brain Injury (MTBI) is one of the most common neurological disorders. A subset of patients develop persistent cognitive deficits. A number of the brain studies have been conducted to discover the abnormalities and disruptions in the brain functional networks using similar methods to …
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The Long-Term Cognitive and Psychological Effects of Mild Traumatic Brain Injury (mTBI)
<p>Mild Traumatic Brain Injury (mTBI), commonly referred to as a concussion, is a prevalent injury in the United States, with several million occurring every year. Many of these injuries take place while playing a sport, particularly in those activities that have higher rates of impact with another …
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Elucidating the Impact of Previous Head Injury on Cognition, Brain Structure, and Pathophysiology in Cognitively Normal Individuals Across the Adult Lifespan
Mild traumatic brain injury (mTBI), or concussion, is a common experience and awareness of mTBI has been increasing. There has been growing concern regarding potential long-term effects of concussion on cognition and risk for neurodegenerative disorders. This concern is heightened for athletic …
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The role of blood-borne factors in triggering atypical astrocytes
Mild traumatic brain injury (mTBI)/ concussion accounts for 70-90% of all reported TBI cases in the United States and can cause long-term neurological outcomes that negatively impact quality of life. Previous studies revealed that increased blood-brain barrier (BBB) leakage is correlated with poor …
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In Vitro Remodeling of Extracellular Matrix Following Mild Traumatic Brain Injury
… permanent disabilities and even death. Mild TBI (mTBI) is the most common form of TBI comprising about 80-90% of all occurrences. Following a CNS insult like an mTBI, astrocytes can undergo activation resulting in the transformation into reactive astrocytes (RAs). RAs also play an important role …
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Reduced global processing bias in people with a history of mild traumatic brain injury: Grass everywhere and not a field in sight
Mild traumatic brain injury (mTBI) is increasingly recognized as a disconnection syndrome, due to the prevalence of disrupted long-range connections. Long-range connections refer to neural pathways that span across brain regions, allowing communication and synchronization between different brain …
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Characterising In Vivo Brain Function Following Mild Traumatic Brain Injury
… 70% of TBIs are Mild traumatic brain injuries (mTBIs), yet, despite this incidence, these patients remain understudied on the assumption that they make near-complete recoveries with little to no mortality. However, literature shows that 80% of patients report at least one post-traumatic symptom …
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Electrophysiological analysis of the sleep onset period : a comparison between subjects with long term insomnia complaints associated with mild traumatic brain injury and matched controls /
… insomnia following mild traumatic brain injury (MTBI). While many believe that symptoms of post concussion syndrome (PCS) following MTBI resolve within 6 to 12 months, there are a number of people who complain of persistent sleep difficulty. Two models were proposed which hypothesize alternate …
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Propranolol Elicits Long Term Systemic Effects After Repetitive Mild Traumatic Brain Injury
… chronic side effect with prevalence of 47-95% of mTBI patients within a week of injury. Though the mechanisms after TBI leading to these headaches and other post mTBI side effects are poorly understood, recent studies have suggested the role of the immune system after injury plays a causal role in …
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Mild traumatic brain injury augments innate immune responses through neurokinin and cholinergic signaling
… we generated a mild tail trauma (TT) model. mTBI mice showed protection from bacterial pneumonia while TT mice did not. Using an FDA-approved neurokinin-1 receptor (NK1R) antagonist, aprepitant, we confirmed our previous findings that substance P (SP) is a key mediator of enhanced resistance …
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Differences in brain architecture during long-term recovery following mild traumatic brain injury
Mild TBI (mTBI) is brain trauma from an external impact with a loss of consciousness less than 30 minutes. mTBI results in several biopsychosocial impairments with pronounced cognitive deficits, thought to resolve within three months of injury. Previous research suggests that these impairments are …
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The KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome
… each year sustain a mild traumatic brain injury (mTBI). Unfortunately, approximately 15% of these patients will have post- concussive symptoms that last longer than three months. Knowledge of the pathophysiological processes underlying susceptibility to poor outcomes is limited, which has impaired …
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The effect of mild traumatic brain injury on cytokine expression in brain tissue
… suggests that mild traumatic brain injury (mTBI) results in significant cognitive and behavioral learning deficit, as well as long-term depressive like behavior in mice. mTBI has been identified as a major initiating event in long-term depressive-like behavior and early fatality observed in …
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An Assessment of Frontal Lobe Activity and BDNF Levels Following Concussion in Collegiate Athletes: A Near-Infrared Spectroscopy Study
… can result in a mild traumatic brain injury (mTBI), known as a concussion. Previous research has assessed how mTBIs affect the brain, but these assessments are limited in their ability to directly measure the consequences of mTBI. Along with concussion assessments, only a few studies have used …
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The Role of Injury Mechanism in Neurogenesis Following Repeated Mild Traumatic Brain Injury in the Dentate Gyrus
Mild traumatic brain injury (mTBI) accounts for approximately 73-83% of all traumatic brain injuries (TBI) and continues to be a serious clinical challenge [1]. The role of injury mechanism in TBI has been widely debated, and it is believed that although there are differences between diffuse and …
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Mitochondria, Inflammation, and T-Cell Metabolism in a Rat Model of Pediatric Mild Traumatic Brain Injury
… pathophysiological patterns after pediatric mTBI from the perspectives of mitochondrial function, inflammation, and T-cell metabolism. First, we documented females having greater mitochondrial oxygen consumption in brain cells 21 days after a single mTBI, offering insight into one mechanism …
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Understanding real-world and laboratory traumatic brain injury (TBI) using the computational model with brain functional regions
… (TBI), including mild traumatic brain injury (mTBI) or concussion, is a severe health concern. Many symptoms, such as headache, dizziness, and working memory deficits, are reported to be related to the dysfunction of brain functional regions, but the underlying mechanism remains unknown. Hence, …
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Antioxidant Biomarkers and Nutraceutical Therapeutics in Neurodegeneration and Neurotrauma
<p>Mild traumatic brain injury (mTBI), yielding a Glascow Coma Scale of 13-15, is the most commonly occurring severity of TBI. Pathology from mTBI consists of blood brain barrier disruption, neuroinflammation, oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, axonal …
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Persistent Effects of Paediatric Mild Traumatic Brain Injury: The Role of Resilience
… of multiple mild traumatic brain injuries (mTBIs) and psychological resilience to persistent post-concussion symptoms (PCS). Methods. Participants (N = 65), ages 8-18 years, who sustained multiple mTBIs (n = 24), a single mTBI (n = 22), or an orthopaedic injury (OI; n = 19) were recruited …
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Unveiling Gender Bias: An Examination of Healthcare Provider Diagnosis of Mild Traumatic Brain Injuries. Insights from Case Vignettes
<p>Mild traumatic brain injury (mTBI) has gained public attention due to increased awareness of its neurological and physical effects, especially among male athletes. This study investigated how healthcare providers diagnose mild traumatic brain injury (mTBI) in male versus female patients by …
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