Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"mSin3A/HDAC1"”.
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Understanding C/EBPbeta LAP/LIP Transcriptional and Adipogenic Potential Through Regulation by HDAC1 and GCN5
… GCN5/PCAF and the deacetylase complex mSin3A/HDAC1 regulate C/EBPβ activity on the C/EBPa promoter. GCN5/PCAF-mediated acetylation of C/EBPβ was shown to positively affect its transcriptional activity in a steroid-dependent mechanism via the glucocorticoid receptor (GR). GR relieves …
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Phenobarbital Induced Transcriptional Activation of CYP2B Genes by Chromatin Modification at the PBRU Region
… and an enhanced inhibition of PBRU by mSin3A/HDAC1 in the presence of SHP were observed which suggested that SHP recruits corepressors to the PBRU to repress the Cyp2b10 gene, possibly in untreated animal. In the chromatin studies, the minimal PBRU (NR-1/NF-1/NR-2) was mapped in a …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
… of chromatin modifying repressive cofactors, mSin3A/HDAC1, NCoR1/HDAC3, methyltransferase G9a, and the Swi/Snf-Brm remodeling complex, to the CYP7A1 promoter. Mutation of the Arg-57 site to Trp (R57W is the naturallyoccurring mutant) decreased SHP interaction with corepressors that we had …