Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"mRNA vaccines"”.
-
SAFETY, EFFICACY, AND IMMUNOGENICITY OF SARS-COV-2 MRNA VACCINES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
mRNA vaccines mark a significant advancement in immunization, extending potential applications beyond COVID-19. Although mRNA vaccines are effective in healthy individuals, their safety and efficacy in autoimmune conditions like systemic lupus erythematosus (SLE), a type 1-interferon-driven …
-
Discovery of Immunogenic Neopeptides from Chimeric RNAs to Develop Peptide and mRNA Vaccines for Lung Cancer Treatment
… neoantigens from fusion junctions, and design vaccines for the treatment of cancer.
-
Pertussis: Advances in Vaccine Development and Disease Control Strategies
… and BapC as potential components for acellular vaccines. Additionally, it discusses current trends in pertussis research and development, including mRNA vaccines and live-attenuated vaccines, as well as other control strategies. The thesis highlights the limitations of current acellular vaccines …
-
DEVELOPMENT OF A VACCINE FOR LYME DISEASE USING THE NUCLEOSIDE-MODIFIED mRNA-LNP PLATFORM
… nanoparticle-encapsulated nucleoside-modified mRNA (mRNA-LNP) platform to generate a Lyme disease vaccine like the successful clinical vaccines against SARS-CoV-2. Of the antigens expressed by Borrelia burgdorferi, the causative agent of Lyme disease, outer surface protein A (OspA) is the most …
-
Defining mRNA-generated T cell memory in respiratory viral infection
… the ability of T cells generated by novel mRNA-LNP vaccines to restrict viral infection in currently unknown. To address this, we studied antigen specific T cell memory generated by mRNA-LNP vaccines in both humans and mice. We report that functional and durable T cell memory is induced by …
-
Exploring the cytotoxicity of polycations
… delivery of genetic material in vitro, such as mRNA-vaccines, non-viral vectors are used as the transporting system. To enable the full potential of the vectors, a positive charge on the surface is necessary, which has been proven to have cytotoxic effects. The aim is to, with polyethylene …
-
Financial and Analytic Innovations for Therapeutic Development
… two disease areas: glioblastoma therapeutics and mRNA vaccines for emerging infectious diseases. By calibrating the simulation parameters with inputs from domain experts, we find a sharp contrast between the risk/return profiles of the two megafunds. While the megafund for glioblastoma achieves an …
-
COVID-VACCINES IN PREGNANCY: MATERNAL AND NEONATAL RESPONSE OVER THE FIRST 9 MONTHS AFTER DELIVERY
… explores the impact of maternal SARS-CoV-2 mRNA vaccination during pregnancy, focusing on its efficacy in generating immune responses, transplacental antibody transfer, and the subsequent immunity conferred to newborns. The study aims to address gaps in understanding the duration and …
-
Novel Lipid Polymer Design for Nucleic Acids Delivery
… therapy and the rapid deployment of LNP-based mRNA vaccines against COVID-19. However, achieving efficient and targeted delivery of nucleic acids to solid tumors remains a significant barrier. Polyethyleneimine (PEI), in particular, was once considered the gold standard in polymer-based nucleic …
-
Design of novel delivery systems to probe alternative routes of administration for a self-amplifying RNA rabies vaccine
Current vaccine design aims to develop safer vaccines based on one or few selected antigens. RNA-based vaccines can be engineered to encode any antigen of interest and have the potential for rapid, inexpensive and scalable manufacturing and have an acceptable safety profile. Moreover, they enable …
-
Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation
… pandemic led to the rapid development of vaccines against the virus. Two of the major vaccines administered in the UK and elsewhere utilised novel mRNA technology to produce an immune response against the viral spike protein. The efficacy of these vaccines was key to control the pandemic …
-
DEVELOPMENT OF AN IN VIVO MULTITASKING BIOLUMINESCENT REPORTER GENE PLATFORM FOR THE PRECLINICAL EVALUATION OF RNA THERAPEUTICS
… of immune activation induced by anti-RidA mRNA vaccines both unmodified and N1-methyl-pseudouridine–modified sequences. This approach generated a spatiotemporally resolved atlas of vaccine-induced signalling, revealing formulation-dependent innate immune dynamics and identifying the liver …
-
Essays on Economic Growth and Innovation
… that it explains the historical development of mRNA vaccines, and I explore its implications for the highly concentrated innovation of artificial intelligence. Chapter 2. In the second chapter, joint with Rebekah Dix, we observe that innovations often combine several components to achieve …
-
Effective Strategies for Preventing and Mitigating Emerging Viruses
… of a vaccine crucial. Live-attenuated vaccines (LAVs) have traditionally been a promising strategy due to their high immunogenicity and cost-effectiveness. However, concerns regarding adverse side effects and the potential for viral replication leading to pathogenic reversions or …
-
Tie-ing the endothelium: development of an mRNA-based nanotherapeutic to restore microvascular barrier function for the treatment of sepsis-induced multiple organ failure
… efficacy. The global success of the COVID-19 vaccines has showcased the use of messenger RNA (mRNA) as a therapeutic modality for transient upregulation of protein expression and precise modulation of cellular pathways. However, intracellular delivery of mRNA remains a hurdle due to its large …