Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"mRNA vaccine"”.
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Manufacturing GMP-grade mRNA vaccine-associated Enzymes: Bioprocess Development and Economics
… on imported GMP-grade recombinant enzymes for mRNA vaccine production represents a critical vulnerability in continental health security, exposed most acutely during the SARS-CoV-2 pandemic. This thesis provides a framework for estimating the financial viability of manufacturing six essential …
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How Pharmaceutical Companies Utilize Platform Strategy: A Study of the COVID-19 mRNA Vaccine Development
… and BioNTech were able to develop the COVID-19 vaccine so rapidly and provides new insights into platform theory. The COVID-19 pandemic, which began in China in late 2019, spread globally within a month, causing immense damage. Vaccines were the most critical technology needed to fight the …
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Of Mice, Ferrets, And Men: From Original Antigenic Sin To A New Universal Influenza Virus Vaccine Candidate
… infection from various subtypes, and universal vaccine platforms are being developed to induce these antibodies. Here we show that experimentally infected ferrets and naturally infected humans establish strong “immunological imprints” against HA stalk antigens first encountered during primary …
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Design and development of an RNA vaccine against tumor-mediated angiogenesis and metastasis targeting a KLH-Adrenomedullin fusion protein
… therapy. In this study, we designed and tested a mRNA vaccine directed against a fusion antigen composed by a small piece of keyhole limpet hemocyanin (KLH), as a hapten, and mouse AM. The in vitro-synthesized mRNA was encapsulated in lipid nanoparticles (LNPs) and injected in C57BL/6J mice. Empty …
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Evaluating the Impact of Local Vaccine Manufacturing on the Resilience and Responsiveness of the Vaccine Supply Chain: A Case Study within South Africa
… revealed significant vulnerabilities in global vaccine supply chains, particularly in low- and middle-income countries dependent on imports. In South Africa, supply disruptions delayed access to essential vaccines, demonstrating the critical need for resilient and responsive vaccine distribution …
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Host Immune-Microbial Interactions in Inflammatory States
… (HD) when stimulated with the SARS-CoV-2 mRNA vaccine, as well as (2) associations between the immune transcriptome with gut microbiome in sarcoidosis patients. Given the complexity of the immune system, we employed omics technologies and approaches that would span the gene, protein, and …
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Risk and Uncertainty in Healthcare Finance, Investment Management, and Asset Pricing
… consider both the development and deployment of vaccines for emerging infectious diseases. Using the COVID-19 pandemic as a case study, we develop a quantitative method to simulate and evaluate various vaccine allocation strategies when the supply of vaccines is subject to stochastic shocks. We …
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Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation
… pandemic led to the rapid development of vaccines against the virus. Two of the major vaccines administered in the UK and elsewhere utilised novel mRNA technology to produce an immune response against the viral spike protein. The efficacy of these vaccines was key to control the pandemic …
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Methods to Study Antigen-Specific B cells
… response after vaccination with the SARS-CoV-2 mRNA vaccine BNT162b2. Specifically, I sorted RBD- or S1-specific plasmablasts after the second vaccine dose. Finally, I devised an Illumina-based sequencing and analysis strategy to generate antibody sequences from multiple plates of sorted …
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INFECTION- AND VACCINE-INDUCED IMMUNE RESPONSES TO SARS-COV-2 AND OTHER HUMAN CORONAVIRUSES
… saw the development and approval of different mRNA and adenovirus-vectored vaccines targeting the spike protein of the virus to protect against infection and severe disease to varying degrees. However, while vaccine-induced responses have been extensively studied in the general population, …
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SARS-CoV-2 Variants and Vaccines
… mask wearing and social distancing. Several vaccines were rapidly developed. These included BioNTech Pfizer’s BNT162b2 mRNA-based vaccine, Moderna’s mRNA-1273 mRNA-based vaccine, and Oxford AstraZeneca’s viral vectored AZD1222 vaccine. These were administered to the public in mass vaccination …
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Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
… each year. There are two live oral attenuated vaccines licensed for use in the United States that are highly effective in high-income countries but much less so in low-and middle-income countries (LMICs). Several factors contributing to decreased efficacy in these areas include chronic …