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Showing 1 to 9 of 9 for “"mRNA turnover"”.

  1. Proteins and instability elements involved in phosphoenolpyruvate carboxykinase mRNA turnover

    Hajarnis, Sachin Shrikant, author, Curthoys, Norman, advisor, Bamburg, James, committee member, Mykles, Donald, committee member, Laybourn, Paul, committee member, Wilusz, Jeffrey, committee memberColorado State University. Libraries2006

    … information about the factors that regulate the turnover of the PEPCK mRNA. Preliminary studies indicated that the 3'-UTR of the PEPCK mRNA binds to proteins from rat renal cortical cytoplasmic extracts. RNA binding proteins can modulate the levels of mRNAs by either stabilizing or targeting the …

    colostate Repository record

  2. Global analysis of mRNA decay rates and RNA-binding specificity reveals novel roles for CUGBP1 and PARN deadenylase in muscle cells

    Lee, Jerome Edward, author, Wilusz, Carol J., advisor, Wilusz, Jeffrey, advisor, Garrity, Deborah M., committee member, Curthoys, Norman P., committee memberColorado State University. Libraries2011

    … and MBNL1 are disrupted, resulting in altered mRNA metabolism at the levels of splicing and translation. Intriguingly, despite strong evidence for CUGBP1 being a regulator of mRNA turnover in humans and other organisms, the possibility that defects in mRNA decay contribute to DM1 pathogenesis …

    colostate Repository record

  3. Characterization of the instability elements present within the 3' UTR of the glutaminase mRNA in WKPT kidney cells

    Lee, Yeon Jean, author, Curthoys, Norman P., advisor, Bamburg, James R., committee member, Laybourn, Paul, committee member, Suchman, Erica, committee member, Wilusz, Jeffrey, committee memberColorado State University. Libraries2006

    … results from increased stability of the GA mRNA that is mediated by two 8-base AU-sequences that function as pH-response elements (pHRE). This sequence binds ζ-cryst and p40-AUF1 with high affinity and specificity. An in vitro mRNA decay assay was developed using cytosolic extracts of WKPT …

    colostate Repository record

  4. The Domains of The Catalytic Subunit of The Eukaryotic Rna Degrading Exosome, Rrp44P, Have Distinct Functions

    Schaeffer, Daneen2011

    … subunits. In the cytoplasm, the exosome degrades mRNA in a general mRNA turnover pathway and in several mRNA surveillance pathways. In the nucleus, the exosome processes RNA precursors to form small, stable, mature RNA species, including rRNA, snRNA, and snoRNA. In addition to processing these …

    uthsc Repository record

  5. Functional analyses of ζ-crystallin binding to the 3'-UTR of glutaminase (GA) mRNA

    Ibrahim, Hend M. M., author, Curthoys, Norman P., advisor, Bamburg, James R., committee member, Laybourn, Paul, committee member, Stargell, Laurie A., committee member, Mykles, Donald L., committee memberColorado State University. Libraries2006

    … results from selective stabilization of the GA mRNA. LLC-PK1- FBPase+ cells, a pH-responsive porcine kidney cell line, express four distinct GA mRNAs, that are ~2.5, 3.5, 4.5, and 5.0 kb in length. RNase H mapping indicated that three of the GA mRNAs are generated by the use of alternative …

    colostate Repository record

  6. DEVELOPMENT OF SMALL MOLECULES AS INHIBITORS OF FTSZ AND RNPA ACTING AS POTENTIAL ANTIMICROBIAL AGENTS

    SUIGO, LORENZOUniversità degli Studi di Milano2023

    … S. aureus essential for two cellular processes: mRNA degradation and precursor tRNA (ptRNA) maturation. Indeed, RnpA alone can catalyse the degradation of bulk mRNA thus promoting mRNA turnover among different growth phases (exponential and stationary). Furthermore, RnpA is able to associate with …

    milano Repository record

  7. The Roles of Rnt1 and Putative Endoribonucleases in Eukaryotic mRNA Degradation

    Notice-Sarpaning, Lee-Ann, <p>0000-0002-9449-873X</p>2026

    … especially with regard to their role in nuclear mRNA degradation. Rnt1 is a <em>Saccharomyces cerevisiae</em> (budding yeast) nuclear endoribonuclease and homolog of human Drosha with well-characterized roles in the processing of ncRNAs. The enzyme recognizes and cleaves double-stranded RNA stems …

    uthsc Repository record

  8. Apobec-1 Complementation Factor (ACF) Binds and Regulates Multiple RNAs

    Delaney, Kimberly2010

    … range of transcripts that function to regulate mRNA stability, localization, and/or translation through interaction with ARE-Binding Proteins. Apobec-1 Complementation Factor: ACF) was originally identified as a co-factor in ApoB mRNA C to U editing, but has recently been implicated in …

    wustl Repository record

  9. Role of PABP4 in intrauterine growth restriction

    Lorbeer, MathiasThe University of Edinburgh2023

    … as central regulator of both global and mRNA-specific translation and mRNA turnover in vitro and in cell lines, but almost nothing is known about the roles of these so-called “somatic PABPs” in mammalian physiology. Here, we aim to address this, building on unpublished data in our …

    edinburgh Repository record