Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"mRNA therapy"”.
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Enhancing mRNA stability through the addition of stabilizing untranslated regions
Messenger-RNA (mRNA) therapy, in which mRNA is introduced to cells or tissues to cause a transient expression of specific genes, has applications ranging from tissue engineering to neural regeneration. This transient nature of mRNA, however, limits the duration of gene upregulation, and potentially …
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Understanding the intracellular signalling pathways activated by lipid nanoparticle delivery of mRNA
Messenger RNA (mRNA) therapies rely on lipid nanoparticles (LNPs) as delivery vehicles to transfect exogenously transcribed mRNA into cells for prophylactic or therapeutic use. LNP delivered mRNA (LNP/mRNA) in the clinic can induce a transient, innate immune response resulting in local and systemic …
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Design, Off-Target Toxicity, and Intracellular Processing of Nucleotide-Modified Messenger RNAs for Human Therapies
RNA therapy is a modality, analogous to gene therapy, in which in vitro-transcribed mRNA (IVT mRNA) is introduced to cells for therapeutic applications. IVT mRNA is transfected into target cells, translated, and the fully-synthesised encoded protein exerts a therapeutic effect via specific …