Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"mRNA therapeutics"”.
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Development and applications of peptide barcoded nanoparticles for high-throughput screening of mRNA delivery materials in vivo
mRNA lipid nanoparticles (LNP) present a promising class of therapeutics, with broad applications in protein replacement therapy, gene editing, immunotherapy, and vaccines, owing to their versatility and precise nature. While recent years have seen dramatic improvements in the safety and efficacy …
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Optimization and analysis of lipid nanoparticles for in vivo mRNA delivery
Messenger RNA (mRNA) therapeutics have the potential to treat a diverse array of diseases requiring protein expression, with applications in protein replacement therapies, immunotherapies, and genome engineering. However, the intracellular delivery of mRNA is challenging and necessitates a safe and …
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Engineered synthetic translational control for next generation mRNA gene therapies
Synthetic mRNA is an emerging therapeutic modality for gene and cell therapy. Unlike their synthetic DNA counterparts, synthetic mRNA has an increased safety profile due to its transient gene expression and ability to express outside of the nucleus. Furthermore, it can be more easily delivered to …
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Development and mechanistic analysis of in vivo liposomal nanoparticle delivery of siRNA and mRNA
A limited number of siRNA and mRNA based therapeutics have been developed largely due to the difficulties of efficaciously delivering RNA to cells in vivo. Liposomal nanoparticles (LNPs) have shown some success, but their design is limited by both a lack of information concerning the optimal lipid …
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Enhancing the expression of foreign nucleic acids in mammalian cells via synthetic biology
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Tie-ing the endothelium: development of an mRNA-based nanotherapeutic to restore microvascular barrier function for the treatment of sepsis-induced multiple organ failure
… can hamper organ function. Several Tie2-targeted therapeutics have shown promising preclinical efficacy in sepsis mouse models, but their clinical translation faces challenges. Most, if not all, of these strategies are dependent on the presence of Tie2. However, Tie2 availability is often …