Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"mRNA regulation"”.
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Engineered mRNA regulation using an inducible protein-RNA aptamer interaction
… and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common regulatory mechanism uses inducible protein-RNA interactions to shape diverse aspects of cellular RNA fate. Recapitulating this using a novel set of protein-RNA …
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Exploring the Glucocorticoid Actions of 1α-Hydroxycorticosterone (1α-OH-B) in the Elasmobranch Fishes
… regulated by GCs, I isolated and sequenced the mRNA encoding serum- and glucocorticoid- inducible kinase 1 (SGK1). <em>SGK1 </em>mRNA abundance was upregulated in red blood cells incubated with 1α-OH-B. The results of these studies support the putative GC actions of 1α-OH-B, including the …
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mRNA localization in Caenorhabditis elegans embryogenesis
… regulating protein output, post-transcriptional regulation of mRNA is essential for life. As a result, many mechanisms underlying post-transcriptional regulation are highly conserved across the kingdoms of life. As the spatial resolution of microscopy and sequencing assays has increased, mRNA …
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Mechanisms of persistent translation arrest following global brain ischemia and reperfusion
… studies, my results indicate that the mRNA granules are ribonomic structures involved with mRNA regulation. This finding is significant because it shifts the focus onto mRNA metabolism and away from ribosomal molecular biology. I have identified new pathways to investigate for …
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RNA Deregulation in Metastatic Breast Cancer
… cells RNA is subject to multiple layers of regulation that together generate extensive phenotypic and temporal complexity from a relatively small number of genes. RNA regulation is achieved through the concerted action of multiple RNA binding proteins (RBPs) which themselves are subject to …
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Analysis of the regulation of GIGANTEA transcript and protein accumulation in Arabidopsis and recombinant expression
… cue. One of the major players in flowering time regulation in Arabidopsis thaliana (Arabidopsis) is a component of the photoperiod pathway called GIGANTEA (GI). During the day, circadian clock control of GI transcription together with post-translational control of GI protein levels results in …
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Induction of death in myeloid leukaemia cells by doxorubicin and betulinic acid, singly and in combination was associated with the regulation of apoptosis, autophagy and the PI3K/Akt pathways
… eradicate due to their more refractory nature. Deregulation of the B-cell lymphoma 2 (Bcl-2) family of proteins in these cells, which regulates cell death through apoptosis, autophagy and other cell processes, may contribute to this trend. Using chemical agents could modulate these signalling …
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Coordinated Control of Liver-Specific Genes in Cultured Cells from Mice and Rats
<p>Assays of transcription rate and mRNA concentration were designed and employed to measure the production of a series of liver-specific and common mRNAs in fresh livers, primary hepatocyte cultures, and hepatoma cell lines, derived from mice or rats. The transcription rates of many different …
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Investigation of Trans-factors responsible for the developmentally linked instability of a highly regulated mRNA in Trypanosoma brucei
… equal rates. With the reduction of gene specific regulation at the point of transcription initiation, trypanosomes provide a model for post-transcriptional gene regulation. One important mechanism is the regulated instability of mRNAs, the coordination of which is only partly understood. To …