Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"mRNA profiling"”.
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Computational and experimental detection of uncoupling between transcriptome and translatome changes of gene expression
Transcriptome analysis by total mRNA profiling provides a measurement of the degree of variation for the amount of each single mRNA species after a physiological or pathological transition of cell state. It has become a general notion that variations in protein levels do not necessarily correlate …
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A constraint optimization framework for discovery of cellular signaling and regulatory networks
… DNaseI hypersensitivity sequencing and mRNA profiling data from the U87MG glioblastoma cell lines over-expressing the variant III mutant of the epidermal growth factor receptor (EGFRvIII). In both cases the method identifies changes in diverse cellular processes that extend far beyond …
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Enhanced striatal glutamatergic function upon chronic antipsychotic action
… increased synaptic function. Cell type-specific mRNA profiling on spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways following chronic antipsychotic administration revealed cell type-specific molecular alterations indicating increases in components of the …
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Copper-64 radiopharmaceuticals for receptor-mediated tumor imaging and radiotherapy
… pattern of these cell lines found via EGFR mRNA profiling. This constitutes a first step in the evaluation of cetuximab for the treatment, and of 64Cu-DOTA-cetuximab for the imaging of advanced cervical cancer, as EGFR expression on the tumor cell surface clearly can be quantified and …
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Dimensionality Reduction, Feature Selection and Visualization of Biological Data
… network, functional gene sets information and mRNA profiling data. The workflow includes three major steps: First, by combining PPI network structure and gene-gene co-expression relationship into a new distance metric, we apply affinity propagation clustering (APC) to build gene sub-networks; …
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Fully Integrated Modular and Mixed-Scale Systems for Processing the Molecular Cargo of Liquid Biopsy Markers
… circulating tumor cells or EVs then performing mRNA profiling, protein analysis, or sequencing on the particular marker. In this work, several aspects of this universal molecular processing platform were studied. A microfluidic module for upstream isolation of bio-nanoparticles from liquid …
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Messenger Rna Profiling: A Prototype Method For Body Fluidand Tissue Identification
… the presence and relative abundance of specific mRNA species. If the type and abundance of mRNAs can be determined in a stain or tissue sample recovered at the crime scene, it would be possible to definitively identify the tissue or body fluid in question. Advantages of an mRNA-based approach, …