Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"mRNA localisation"”.
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Towards understanding the mechanisms behind mRNA localisation in growing axons
During embryonic nervous system assembly, mRNA localisation is precisely regulated in growing axons, affording subcellular autonomy by allowing controlled protein expression in space and time. Different sets of mRNAs exhibit different localisation patterns across the axon. Little is known, however, …
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Mechanism of mRNA localisation and posttranscriptional modification in Drosophila melanogaster embryonic neurons
… on post-transcriptional events. Two prevalent mRNA-based regulatory mechanisms in neurons are asymmetric mRNA localisation and the generation of different 3’UTR isoforms by alternative polyadenylation (APA). While experiments in mammalian systems indicate that subcellular mRNA localisation …
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Investigating the regulation of processing bodies in Drosophila melanogaster oocytes
… RNA-protein complexes play critical roles in mRNA localisation, translation, and degradation. Within this category, processing bodies (P bodies) are evolutionarily conserved RNP granules found in yeast to humans. In Drosophila melanogaster, P bodies play a crucial role in regulating the …
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Mechanisms governing transposable element expression in the Drosophila germ line
… through differential transcript subcellular localisation. Genetic screening of candidate regulators led to the identification of a new factor required for suppression of transposon activity, Megator. Finally, I established a transgenic system to recruit specific factors to a P-element …