Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"mRNA downregulation"”.
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TIS21 inhibits cell migration and invasion
… shape. TIS21 overexpression was correlated with downregulation of focal adhesion kinase (FAK) tyr576 and tyr925 residues phosphorylation. However, tyr397 which was autophosphorylation site was not influenced by TIS21 expression. c-Src phosphorylation which was upstream of FAK was not influenced …
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Post-Transcriptional Regulation of Mammalian Gene Expression In Non-Coding Region of Target Rna
… in the human chromosome 3p21.3 region. TUSC2 mRNA transcripts could be detected on Northern blots in both normal lung and some lung cancer cell lines, but no endogenous TUSC2 protein could be detected in a majority of lung cancer cell lines. Mechanisms regulating TUSC2 protein expression and …
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Angiotensin II-mediated Regulation of the Human Angiotensin II Type 1 Receptor Gene
… AT1R on binding its ligand, Ang II, leads to downregulation of cell-surface receptor and also its mRNA. We have investigated whether the 3'- and 5'-untranslated regions of the human AT1R mRNA mediate the degradation of hAT1R mRNA by post-transcriptional mechanisms in human adrenocortical …
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Function and regulation of poly(A)-tail length
… 3' ends of nearly all eukaryotic messenger RNAs (mRNAs) and long non-coding RNAs. The presence of a poly(A) tail promotes translation and inhibits decay of an mRNA, with both effects mediated through poly(A)-binding protein. However, an understanding of the relationship between the length of a …
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Role of mural Cx43 in vascular interactions and its regulation by breast tumor cells
… MDA-MB-231 breast tumor cells downregulates Cx43 mRNA and protein to release endothelial cells from mural cell-mediated growth inhibition. We also report that Ang-Tie signaling is involved in tumor induced Cx43 loss and release of endothelial proliferation. Since Cx43 function and half-life can …
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An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model.
… pathways - nrf2 (HO-1), NFĸB (IL-6 mRNA), HIF-1α (VEGF) and PECAM-1 - were examined. HIF-1α, nrf2, HO-1, PECAM-1, VEGF, and NFᴋB levels were detected by immunocytochemical/immunohistochemistry and/or by Western blotting (WB). Total RNA was isolated from HDMEC and cDNA prepared and …