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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 49 for “"mRNA decay"”.

  1. Regulation of mRNA decay by Pumilio in Drosophila melanogaster

    Kekis, Mariana2013

    … development is driven by maternally loaded mRNAs synthesized in the female parent during oogenesis. These maternally synthesized mRNAs are regulated by post-transcriptional mechanisms, including mRNA localization, degradation and translational activation and repression. Many of these …

    toronto-retro Repository record

  2. Characterization of nonsense mediated mRNA decay in Schizosaccharomyces pombe

    Wen, JikaiUniversity of Birmingham2010

    Nonsense mediated mRNA decay (NMD) is a translation-coupled process that preferentially destroys mRNAs harboring premature translation termination codons (PTCs). In mammalian cells, NMD is linked to pre-mRNA splicing. Typically, PTCs elicit strong NMD only if positioned upstream of at least one …

    birmingham Repository record

  3. The Regulation of ARE-Mediated mRNA Decay During Colorectal Tumorigenesis

    Blanco, Fernando Filippini

    … in the 3' untranslated region (3'UTR) of their mRNA, thereby targeting them for rapid decay in a process known as ARE-mediated mRNA decay. It has been previously shown that ARE-mediated mRNA decay occurs in cytoplasmic RNA decay centers known as processing bodies (P-bodies). However, the …

    south-carolina Repository record

  4. Functions of Deadenylation Factors In Mrna Decay and Mrna Processing Body Formation

    Zheng, Dinghai2010

    … because deadenylation not only leads to mRNA translational inhibition but also is the first step of major mRNA degradation. Translationally inhibited mRNAs can be stored and/or degraded in dynamic cytoplasmic foci termed mRNA processing bodies, or P bodies, which are conserved in …

    uthsc Repository record

  5. Physiological role and quantitative aspects of human Nonsense-mediated mRNA decay (NMD)

    Viegas, MarceloUniversität Heidelberg

    Nonsense-mediated mRNA decay (NMD) is a molecular pathway of mRNA surveillance that ensures the rapid degradation of mRNAs containing premature translation termination codons in all studied eukaryotes. Originally, NMD was thought of as a quality control pathway that targets non-functional mRNAs …

    heid-diss Repository record

  6. Twist of messenger Fate: novel mechanisms for TDP43 in modulating mRNA decay and alternative polyadenylation

    Potrich, ValentinaUniversità degli studi di Trento2017

    … revealed the interaction with components of the mRNA surveillance pathway, suggesting a still undiscovered function in nonsense-mediated decay. We demonstrated that TDP43 acts translation- and SMG1-dependently as a mRNA decay enhancer of specific transcripts by binding their 3’UTR. In particular, …

    trento Repository record

  7. Isolation and characterization of Hupf1-containing protein complexes and their role in nonsense-mediated mRNA decay

    Schell, Thomas

    mRNAs containing premature translation termination codons (PTCs) are usually degraded by the nonsense-mediated mRNA decay (NMD) pathway. The mechanism of NMD in mammals is largely unknown. The cytoplasmic protein Hupf1 was the only trans-acting factor of NMD in mammals that was known at the …

    freiburg-diss Repository record

  8. Global analysis of mRNA decay rates and RNA-binding specificity reveals novel roles for CUGBP1 and PARN deadenylase in muscle cells

    Lee, Jerome Edward, author, Wilusz, Carol J., advisor, Wilusz, Jeffrey, advisor, Garrity, Deborah M., committee member, Curthoys, Norman P., committee memberColorado State University. Libraries2011

    … and MBNL1 are disrupted, resulting in altered mRNA metabolism at the levels of splicing and translation. Intriguingly, despite strong evidence for CUGBP1 being a regulator of mRNA turnover in humans and other organisms, the possibility that defects in mRNA decay contribute to DM1 pathogenesis …

    colostate Repository record

  9. Form and function of Poly(A) tails

    Eisen, Timothy J.(Timothy Jonas)Massachusetts Institute of Technology2020

    Central to mRNA metabolism is the poly(A)-tail, a stretch of adenosine nucleotides at the mRNA 3' end. In this dissertation, I investigate the role of the tail in the dynamics of mRNA decay, and describe the predominant mechanisms of decay for thousands of mammalian mRNAs. Next, I examine the …

    mit Repository record

  10. The Role of Edc3 in Drosophila Melanogaster Neuronal Development

    Zius, Keelan2025

    <p>Enhancer of mRNA-decay 3 (Edc3) is a component of multiple decapping complexes that regulates the transcriptome by targeting a subset of transcripts for decapping for 5’-to-3’ messenger RNA (mRNA) decay. A missense mutation in the conserved Lsm domain of Edc3 has been reported in two siblings …

    denver Repository record

  11. Functions of Dcp2 and Ski7 In Mrna Degradation

    Kim, Minseon, van Hoof, Ambro, <p>0000-0001-5299-0008</p>2022

    … fidelity. This is partially achieved by mRNA decay. When no longer required, mRNA is degraded by two alternative pathways. The decapping enzyme Dcp2 removes the 5` <sup>m7</sup>G cap of mRNAs, allowing Xrn1 to degrade the mRNA from the 5` end. Alternatively, mRNA is degraded from the 3` …

    uthsc Repository record

  12. Regulation and function of the RNA-binding protein CELF1

    Beisang, Daniel Joseph2012

    … Coordinate regulation of the rate of decay of networks of functionally related mRNA provides a cell the ability to quickly and precisely alter its transcriptome in response to environmental signals. An important regulator of mRNA decay is the RNA binding protein CUGBP1 and Etr3 Like …

    umn Repository record

  13. THE ROLE OF SELECTIVE MRNA DEADENYLATION IN THE HOMEOSTATIC CONTROL OF INNATE IMMUNE SIGNALING

    Braun, Rachel, Marilyn2026

    … Tristetraprolin, and selective factors of the mRNA deadenylation machinery post-transcriptionally control interferon mRNAs both at steady state and post-stimulation. Loss of these mRNA decay factors leads to increased interferon levels and increased interferon signaling. Mechanistically, we …

    penn Repository record

  14. Identification of substrate-selective histone deacetylases and their inhibitors that mediate HER2 transcript stability

    Alejo, Mariah2021

    … that HDAC inhibitors can induce the rapid decay of oncogenic transcripts such as the HER2 mRNA, though the mechanism underlying this process remains undefined. Earlier observations in our lab led to speculation that protein(s) binding the 3’-untranslated region (UTR) of HER2 mRNA become …

    dominican Repository record

  15. mRNA stability in soma and neurites of cultured neuronal cells

    Srinath, ChetanMassachusetts Institute of Technology2017

    Neurons rely on mRNA localization and local protein synthesis in neurites to regulate synaptic plasticity, axonogenesis and neural signaling. The local regulation of mRNA stability in neurites is poorly understood. To determine mRNA decay rates, we analyzed the subcellular transcriptomes of neural …

    mit Repository record

  16. Analysis of AUF1 targeted mRNA sequences

    Lu, Jiebo

    … binding protein, plays an important role in mRNA decay. To identify the mRNAs that interact with AUF 1, mRNA derived from a human cardiac cDNA expression library was purified by AUF 1 affinity chromatography and cloned following RT-PCR. 261 sequences were obtained. The sequences were searched …

    njit Repository record

  17. Tissue-specific classification of alternatively spliced human exons

    Rothman, Craig JeremyMassachusetts Institute of Technology2007

    … and susceptibility to nonsense-mediated mRNA decay caused by skipping. Cis-element motifs that might bind protein factors that affect splicing were identified using overrepresentation analysis and conserved occurrence rate between human and mouse.

    mit Repository record

  18. Functions of The Trna Splicing Endonuclease and Other Adventures In Rna Processing

    Hurtig, Jennifer, van Hoof, Ambro, <p>0000-0003-1243-1492</p>2024

    … other function of the TSEN complex. TSEN has one mRNA target in yeast which led me to the hypothesis that TSEN could cleave other mRNAs. I used Parallel Analysis of RNA Ends (PARE) to identify other mRNA substrates of TSEN. I found TSEN cleaves a subset of mRNAs that encode mitochondrial localized …

    uthsc Repository record

  19. Messenger RNA Destabilization by -1 Programmed Ribosomal Frameshifting

    Belew, Ashton Trey2012

    … genomic sequences, and suggested a role in mRNA stability. This work improves and extends the computational methods used to search for potential -1 PRF signals. It continues to examine four yeast -1 PRF signals and show that they promote significant mRNA destabilization through the nonsense …

    maryland Repository record

  20. Sindbis virus usurps the cellular HUR protein to stabilize its transcripts and promote infections of mammalian and mosquito cells

    Sokoloski, Kevin J., author, Wilusz, Jeffrey, advisor, Wilusz, Carol, advisor, Blair, Carol, committee member, Peersen, Olve, committee member, Quackenbush, Sandra, committee memberColorado State University. Libraries2010

    … RNAs of Sindbis virus strongly resemble cellular mRNAs as they are capped at their 5’ ends and polyadenylated at their 3’ termini. These features allow the viral RNAs to act like cellular mRNAs and make them prime substrates for the cellular mRNA decay machinery. Sindbis virus RNAs are indeed …

    colostate Repository record

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