Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"mRNA deadenylation"”.
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THE ROLE OF SELECTIVE MRNA DEADENYLATION IN THE HOMEOSTATIC CONTROL OF INNATE IMMUNE SIGNALING
… Tristetraprolin, and selective factors of the mRNA deadenylation machinery post-transcriptionally control interferon mRNAs both at steady state and post-stimulation. Loss of these mRNA decay factors leads to increased interferon levels and increased interferon signaling. Mechanistically, we …
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The Role of Phosphorylation In Pam2 Motif-Containing Proteins Mediated Messenger Rna Deadenylation
… many cellular processes. However, its role in mRNA deadenylation, a process to remove poly adenosines from the mature mRNA 3’ end tail, is unclear. The length of poly(A) tail determines mRNA stability and translation efficiency. Poly(A)-binding protein (PABP), which binds to newly synthesized …
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Analysis of the role of poly(A) -binding protein (PAB1) in the mRNA degradation process in yeast
<p>The mRNA deadenylation process influences multiple aspects of protein synthesis and is known to be the major factor controlling mRNA decay rates. My data demonstrates that yeast PAB1 plays both positive and negative roles in controlling deadenylation, and I have identified particular regions of …
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Functions of Deadenylation Factors In Mrna Decay and Mrna Processing Body Formation
… process of poly(A) tail shortening, also termed deadenylation, is important for post-transcriptional gene regulation, because deadenylation not only leads to mRNA translational inhibition but also is the first step of major mRNA degradation. Translationally inhibited mRNAs can be stored and/or …
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ZFP36L3: a Unique Member of the Tristetraprolin Family of RNA-Binding Tandem Zinc Finger Proteins
… the 3' untranslated regions of certain cellular mRNAs, leading to their deadenylation and destabilization. Studies in knockout mice have demonstrated roles for three of the family members, TTP, ZFP36L1 (L1), and ZFP36L2 (L2), in inflammation, chorioallantoic fusion, and hematopoiesis, …