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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 84 for “"mPFC"”.

  1. The long-lasting effect of early life stress in mPFC: excitatory and inhibitory balance in a murine model of anxiety

    Eva, Carola Eugenia, Ghigo, MattiaUniversità degli Studi di Torino2020

    unito Repository record

  2. Dopaminergic modulation of prefrontal cortex subpopulations

    Vander Weele, Caitlin MiyaMassachusetts Institute of Technology2018

    … dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioral functions, the precise circuit computations remain elusive. One potentially unifying theoretical model by which dopamine can modulate functions from working memory to schizophrenia is that dopamine serves …

    mit Repository record

  3. Role of Medial Prefrontal Cortical Group II Metabotropic Glutamate Receptor in the Development of Cocaine Sensitization

    Xie, Xiaohu2016

    … examined the role of medial prefrontal cortical (mPFC) group II metabotropic glutamate receptors (mGluR<sub>2/3</sub>) in the development of cocaine sensitization. Initial studies demonstrated that intra-mPFC injection of the mGluR<sub>2/3</sub> receptor agonist, APDC, dose-dependently reduced …

    tenn-hsc Repository record

  4. Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction

    Timmer, Kristin Marie2016

    … neurons within the medial prefrontal cortex (mPFC). Such hyperexcitability presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area (VTA) and nucleus accumbens (NAc), consequently facilitating drugseeking behavior. Metabotropic …

    tenn-hsc Repository record

  5. Structure of the Rat Medial Prefrontal Cortex Is Influenced by Sex Across the Lifespan

    Markham, Julie AnneUniversity of Illinois at Urbana-Champaign2015

    … neuron number and glial cell number in the mPFC, as well as frontal white matter volume, were also examined in both sexes using unbiased stereological techniques. Ventral rat mPFC gray matter volume increased prior to puberty and then decreased between puberty and adulthood, especially in …

    uiuc Repository record

  6. Long-range synchrony between medial prefrontal cortex, thalamus and hippocampus underlies working memory behavior in mice.

    O'Neill, Pia-Kelsey Tiu2013

    … in this behavior: the medial prefrontal cortex (mPFC), the hippocampus (HPC) and the medial dorsal thalamus (MD). Lesion and electrophysiological studies in each structure have demonstrated their importance during working memory behavior. Disconnection studies also show that the coordination …

    columbia-diss Repository record

  7. Neuroadaptive Changes in the Mesocortical Glutamatergic System during Nicotine Self-administration and after Extinction in Rats

    Wang, Fan2016

    … of nicotine SA, in the medial prefrontal cortex (mPFC), NMDA receptor subunit 2A (NR2A) and NR2B were increased by 67% and 83%, respectively. In the ventral tegmental area (VTA), glutamate receptor subunit 2/3 (GluR2/3) was increased by 34%. These findings suggest the glutamate neurotransmission …

    tenn-hsc Repository record

  8. Impact of Acute Ethanol Injections on Medial Prefrontal Cortex Neural Activity

    Morningstar, Mitchell D.2019

    The medial prefrontal cortex (mPFC) is a cortical brain region involved in the evaluation and selection of motivationally relevant outcomes. mPFC-mediated cognitive functions are impaired following acute alcohol exposure. In rodent models, ethanol (EtOH) doses as low as 0.75 g/kg yield deficits in …

    iupui Repository record

  9. Effect of medial prefrontal cortex 6-OHDA lesions on behavioral and neurochemical responses to gustatory stimuli

    BIMPISIDIS, ZISISUniversità degli Studi di Cagliari2012

    … and core and in the medial prefrontal cortex (mPFC) in relation to their motivational valence, salience and novelty; the DA increase in the NAc shell is subjected to single trial habituation while in the NAc core and in the mPFC is not. Recently it was shown that sensitization to morphine can …

    cagliari Repository record

  10. Wandering minds, restless brains and mindful thinking : a network-based perspective

    Keller, Joseph BarringtonMassachusetts Institute of Technology2016

    … between the medial prefrontal cortex (MPFC) and dorsolateral prefrontal cortex (DLPFC). The DLPFC is a major component of the executive control network that increased in activation during tasks involving working memory and mental control. Young adults exhibit greater working memory …

    mit Repository record

  11. Role of rat medial prefrontal cortex in time interval estimation

    김, 지은2013

    … requirement of intact medial prefrontal cortex (mPFC) for performing the task and to find the mechanism of time interval estimation. In Experiment 1, I established a temporal discrimination procedure using six different time intervals ranging from 3018 to 4784 ms that needed to be discriminated …

    ajou Repository record

  12. Development of the adolescent prefrontal cortex and basolateral amygdala and the effects of puberty and alcohol exposure

    Koss, WendyUniversity of Illinois at Urbana-Champaign2013

    … task dependent on the medial prefrontal cortex (mPFC). Adolescents were able to perform the task. On certain delays (15s and 30s), however, they were consistently worse than adults indicating that behavior that depends on the mPFC is not yet at adult levels. To identify further neuroanatomical …

    uiuc Repository record

  13. Zeitabhängige Modulation neuronaler Korrelate beim Abruf episodisch-autobiographischer Erinnerungen : Ergebnisse aus zwei fMRT-Studien mit Adoleszenten und jungen Erwachsenen

    Oddo, SilviaUniversität Bielefeld

    … zeigte sich zudem auch eine Beteiligung des MPFC beider Hemisphären. Bei den Adoleszenten waren zwar ebenfalls beide Strukturen involviert, jedoch fast ausschließlich auf einem weniger konservativen Signifikanzniveau. Schließlich zeigte sich für den autobiographischen Gedächtnisabruf ein …

    bielefeld Repository record

  14. The Serotonin (5-HT) 5-HT2A Receptor is a Priority Target to Reduce Impulsive Action in Substance Use Disorders: Preclinical Evidence

    Sholler, Dennis JThe University of Texas Medical Branch at Galveston2019

    … in the medial prefrontal cortex (mPFC) is an important neuromodulator of impulsive action (inability to withhold premature responses), and 5-HT actions at the G protein-coupled 5-HT2A receptor (5-HT2AR) regulate impulsive action and the attentional orienting to drug cues (cue …

    utmb Repository record

  15. Dopaminergic Inputs to the Amygdala: Differential Innervation of Interneurons and Convergence With Cortical Afferents

    Pinard, Courtney Rose

    … input from the medial prefrontal cortex (mPFC). DA releases mPFC inhibition of the BLC, in part, through hyperpolarization of neurons in the intercalated nuclei (ICN), which also receive DA and mPFC innervation. Phaseolus vulgaris leucoagglutinin (PHA-L) anterograde tract-tracer was …

    south-carolina Repository record

  16. Sex differences in the effects of two-hit stress on the structure and function of rat medial prefrontal cortex

    Moench, Kelly M.[Bloomington, Ind.] : Indiana University2019

    … and function of medial prefrontal cortex (mPFC), with numerous neurobiological and behavioral changes observed shortly after the cessation of stress. In contrast, female rats often do not exhibit these same deleterious effects of chronic stress. In this dissertation I investigated if …

    iu Repository record

  17. Cellular and synaptic pathophysiology in a rat model of Fragile X syndrome

    Jackson, AdamThe University of Edinburgh2017

    … the lateral amygdala. Secondly, we investigated mPFC intrinsic excitability and synaptic plasticity in Fmr1 KO rats. The mPFC plays a key role in several of the cognitive functions that are affected in fragile X patients including attention, cognitive flexibility and anxiety (Goto et al., 2010). …

    edinburgh Repository record

  18. Ontogeny of contextual fear conditioning: behavioral, neuropharmacological and molecular mechanisms

    Robinson-Drummer, Patrese A.University of Delaware2018

    … regions in medial prefrontal cortex (mPFC) show a learning-related increase in Egr-1 expression on the training day, whereby immediate shock increases expression in context-preexposed rats that learn fear, relative to control groups that do not. Behavioral expression of the CPFE …

    udel Repository record

  19. The medial prefrontal cortex and the dorsomedial striatum are necessary for working memory in rats: role of NMDA receptors

    Davies, Don 1985-University of Saskatchewan2016

    … (NMDA) receptors in medial prefrontal cortex (mPFC) and dorsomedial striatum (dmSTR) using two working memory tasks. The trial unique non-match to location (TUNL) task is a delayed-non-match-to-sample visual working memory task performed in touchscreen equipped operant conditioning chambers. …

    sask Repository record

  20. Interactions Between Medical Prefrontal Cortex, Orbitofrontal Cortex and Motor Cortex in Value-based Decision Making

    설, 정훈2011

    … cortex (OFC) and medial prefrontal cortex (mPFC) of rats performing a dynamic two-armed bandit (TAB) task. And we also examined neuronal activity in the lateral (AGl) and medial (AGm) agranular cortex, corresponding to the primary and secondary motor cortex, respectively, in rats performing …

    ajou Repository record

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