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Showing 1 to 2 of 2 for “"mPBPK"”.
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Hybrid modeling techniques to support drug-development and post-market analysis of anti-infectives
… minimal physiologically-based pharmacokinetic (mPBPK) platform for anti-TB drug disposition was derived from a full-body version and enriched with an innovative intra-granuloma module described via ODE-based passive diffusion mechanisms. The simultaneous support of severalanti-TB agents and …
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Physiologically-Based Pharmacokinetic (PBPK) Modeling for the Preclinical Development of Spectinamide Antibiotics
Despite being an ancient disease caused by Mycobacterium tuberculosis (Mtb) and after decades of research, tuberculosis (TB) still affects millions of people every year worldwide. In 2018, the World Health Organization (WHO) reported that 10 million people developed tuberculosis and 1.5 million …