Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"mGluR5"”.
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Role of mGluR5 and FMRP in mouse primary somatosensory cortex
… functional consequences of mGluR (predominantly mGluR5)-dependent protein synthesis maybe exaggerated in FXS (Bear et al., 2004). Primary somatosensory cortex (S1) of rodents provides an excellent model system to study the role of MR genes in development because of its stereotypic, glutamate …
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mGluR5 Involvement in Methamphetamine Reward and the Co-Morbidity of Schizophrenia and Stimulant Use Disorders
… I subtype 5 metabotropic glutamate receptor (mGluR5) is highly expressed in brain regions known to be important for stimulant reward. Thus, mGluR5 functions to fine tune neuronal excitability and modulate drug-induced behaviors. It is important, and clinically relevant, to study the neuronal …
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Characterizing the modulation of mGluR5 in a 6-OHDA-induced rat model of Parkinson's disease
… of metabotropic glutamate subtype-5 receptors (mGluR5) in Parkinson's disease (PD). Four analogical PET ligands were used to characterize modulation of mGluR5 function in a 6hydroxydopamine (6-OHDA) induced rat model of PD. Unilateral 6-OHDA lesions were made in the right medial forebrain …
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Metabotropic glutamate receptor 5 : a therapeutic target in Fragile X and a regulator of plasticity in visual cortex
… (FMRP) and metabotropic glutamate receptor 5 (mGluR5) act in functional opposition to regulate local translation of synaptic mRNAs. Fragile X is the most common form of inherited intellectual disability and autism, and is expressed by a loss of FMRP. Previous studies have implicated mGluR5 in …
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
… behavior. Metabotropic glutamate receptor 5 (mGluR5) has been implicated in cocaine addiction and demonstrated to increase neuronal excitability, therefore, the aim of the present study was to investigate the effect of intra-mPFC mGluR5 manipulation on behavioral and neurochemical …
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Untersuchungen zur Expression und pharmakologischen Modulation des metabotropen Glutamatrezeptors 5 in Dystoniemodellen: dtsz Hamstermutante und DYT1 knock-in Maus
… sollte der metabotrope Glutamatrezeptor 5 (mGluR5) in zwei verschiedenen Tiermodellen der Dystonie untersucht werden. Der mGluR5 ist besonders im Bereich des Striatums, der Eingangsstruktur der Basalganglien, stark exprimiert und zudem maßgeblich an der Regulierung der synaptischen …
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Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long Term Depression That Is Affected in Fragile X Syndrome
… I metabotropic glutamate receptors (mGluR1, mGluR5) induces long-term synaptic depression (LTD) that requires rapid, dendritic protein synthesis. The significance of protein synthesis-dependent mGluR LTD to cognitive function is highlighted by the recent finding that mGluR-dependent LTD is …
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Magnetically-driven Therapeutic Agents Delivery System using Iron Oxide Nanocages and Enhancement of Exosome Secretion, a Potential Biological Drug Delivery Carrier
… delivery system further by delivering mGluR5 siRNA to the metastatic osteosarcoma cells. It has been studied that type 5 metabotropic glutamate receptor, mGluR5, is required to proliferate metastatic osteosarcoma cells. Therefore, the proliferation of the osteosarcoma cells would …
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GROUP I METABOTROPIC GLUTAMATE RECEPTORS ON SELECTIVE CELLULAR SUBTYPES IN EPILEPTOGENIC MALFORMED CORTEX
… in low threshold spiking (LTS) interneurons via mGluR5 activation. To determine whether cell specific expression of these receptors was altered in malformed cortex immunohistochemical stains were performed for group I mGluRs along with non-overlapping interneuron subtype specific markers, a …
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An Examination of the Mechanisms of Neocortical Network Excitability in a Mouse Model of Fragile X Syndrome
… to the network hyperexcitation. Disruption of mGluR5 interactions with the scaffolding protein Homer, which results in consitituive mGluR5 signaling, is sufficient to prolong UP states. Futhermore, restoration of Homer-mGluR complexes in the Fmr1 KO reduces UP state duration to wildtype levels. …
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Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference
… mGluR linked to PLD and partially dependent upon mGluR5 and phospholipase C (PLC). Western blots and co-immunoprecipitations revealed increased expression of PLD after cocaine administration and possible physical interactions between group I mGluRs and PLD and DRs and PLD. PLD activity assays …
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An investigation into the role of cannabinoid and group 1 metabotropic glutamate receptors in the control of rhythmic locomotion in hatchling Xenopus Laevis
… in swim cycle frequency whereas inhibition of mGluR5 with 2-Methyl-6-(phenylethynyl)pyridine (MPEP) caused no significant decreases, indicating an intrinsic role for mGluR1 over mGluR5 in the maintenance of normal swim cycle frequency. Antagonism of CB1 with AM-251 caused significant decreases …
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THE ROLE OF THE PROLINE-RICH TYROSINE KINASE 2 PROTEIN IN THE REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALLING
… glutamate receptors (mGluRs) - mGluRl and mGluR5 - are believed to contribute to neuronal death upon overstimulation and may be neuroprotective under other conditions. To develop treatment for mGluRs, we must identify proteins involved in their signalling. We have identified proline-rich …
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The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents
… Chronic cocaine withdrawal did not affect mGluR5-mediated LTP in the basolateral to central amygdala pathway. However, mGluR1-mediated LTP was reduced after cocaine administration and withdrawal and was partially due to GABA inhibition via endocannabinoids.
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Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders
… of V1 require metabotropic glutamate receptor 5 (mGluR5) signaling during postnatal development. Additionally, schizophrenia-associated protein neurogranin overexpression in V1 disrupts juvenile ocular dominance plasticity. Finally, we evaluate SRP in two models of ASDs associated with excitatory/ …
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Contributions of metabotropic glutamate receptors to the pathophysiology of autism
… downstream of metabotropic glutamate receptor 5 (mGluR5) is a shared disruption in these disorders, and therefore may ultimately contribute to the pathophysiology of ASD in general. First, we show that multiple aspects of mGluR-mediated protein synthesis are altered in the mouse model of FX, …
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ELECTROPHYSIOLOGICAL INVESTIGATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY IN DEAF-1 KNOCK-OUT MICE
… NMDA receptors and mGlu receptors (mGluR1 and mGluR5) were explored. Treatment with D-AP5 - a selective NMDAR antagonist on slices from control animals showed no effect on the baseline evoked responses, but LLTP was blocked following D - AP5 treatment. In slices from DEAF1 NKO animals, AP5 did …
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The Physiological and Morphological Responses of the Bladder Urothelium to Differential Injury
… identify that metabotropic glutamate receptor 5: mGluR5) is necessary to experience inflammatory-mediated pain responses. We also correlated molecular markers and pain profiles to identify potential biomarkers for diagnosis or treatment of BPS/IC.</p><p>Although regeneration from bladder injury …
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A Novel Switch-Like Function of Delta-Catenin In Dendrite Development
… my findings implicate the glutamate receptor mGluR5, which has extensive roles in dendrite development, in this pathway. Lastly, my investigation suggested that Rho-family GTPases lie downstream of these delta-catenin complexes, thereby linking them to cytoskeletal regulators with established …
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Modulation of mechanosensitive gastro-oesophageal vagal afferents by novel targets.
… and non-selective antagonists, whilst the mGluR5 antagonist MTEP concentration dependently inhibited mechanosensitivity. Efficacy of agonists and antagonists for the various receptor sub-types differed between mucosal and tension receptors. No role for Kainate receptors was observed in this …
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