Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"mGluR1"”.
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Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long Term Depression That Is Affected in Fragile X Syndrome
… group I metabotropic glutamate receptors (mGluR1, mGluR5) induces long-term synaptic depression (LTD) that requires rapid, dendritic protein synthesis. The significance of protein synthesis-dependent mGluR LTD to cognitive function is highlighted by the recent finding that mGluR-dependent …
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Differential modulation of T-type voltage gated calcium channels by G-protein coupled receptors.
… Cav3.1 channels by a Galpha<q/11>-coupled mGluR (mGluR1) initially characterized in the heterologous system was also observed in a native neuronal system: the cerebellar Purkinje cell (PC). In recordings on PCs within acute cerebellar slices, we demonstrated that the potentiation of Cav3.1 …
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INTERACTION BETWEEN ESTROGEN RECEPTOR AND METABOTROPIC GLUTAMATE RECEPTOR 1 MEDIATES THE DUAL EFFECT OF ESTROGEN IN NEUROPROTECTION AND NEURODEGENERATION
… ascribed to estrogen, can be observed also with mGluR1 agonists. 3,5-Dihydroxyphenylglycine (DHPG) behaves both as a neuroprotective and neurodegenerative factor. The aim of this study has been to point out whether the similar behaviour of the estrogen and mGlu1R agonists depends on the …
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Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference
… mediated via D1 receptors and is dependent upon mGluR1 and the mGluR linked to PLD and partially dependent upon mGluR5 and phospholipase C (PLC). Western blots and co-immunoprecipitations revealed increased expression of PLD after cocaine administration and possible physical interactions between …
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Orbitofrontal Cortex and Social Processing in Rodent Models
… of metabotropic glutamate receptor type 1 and 5 (mGluR1/5) expression in mbTBI but not sham OFC. Exposure-naïve rats intracranially injected with mGluR1/5 agonist demonstrated attenuated SoFiA, and this coincided with an impairment of social recognition (SR) behavior. Additionally, inactivation of …
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An investigation into the role of cannabinoid and group 1 metabotropic glutamate receptors in the control of rhythmic locomotion in hatchling Xenopus Laevis
The group 1 metabotropic glutamate receptors (mGluR1/5) are of key interest in the synaptic plasticity that underlies learning and memory and have been implicated as a cause or target in many disease models such as Parkinson’s, Huntington’s, Alzheimer’s, depression, schizophrenia and fragile X …
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The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents
… to central amygdala pathway. However, mGluR1-mediated LTP was reduced after cocaine administration and withdrawal and was partially due to GABA inhibition via endocannabinoids.
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Understanding the Mechanisms of Motor Learning in the Vestibulo-ocular Reflex
… of type 1 metabotropic glutamate receptors (mGluR1) and B type γ-aminobutyric acid (GABAB) receptors. Blocking one or both of these receptors with an antagonist inverts gain-up learning, while the agonist augments gain-up learning. Furthermore, we provide novel evidence that these receptors …
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IS BRAIN CHOLESTEROL THE MISSING CULPRIT IN DRUG ADDICTION?
… rats. Moreover, the ability of Gαq-coupled mGluR1/5, but not serotonin 5-HT2A/2C receptors, to stimulate PLCβ activity is also decreased in AMPH self-administering rats. These data suggest an association of cholesterol content with Gα subunit compartmentalization and signaling. Using …
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Investigating the role of TRPC3 in the biogenesis of extracellular vesicles
… indicated that TRPC3 and its upstream regulator mGluR1 are incorporated into SKOV3-EVs. Using live single-cell imaging, histamine, Ca2+, and TRPC3 activation were shown to stimulate the release of EVs with distinct characteristics and fusion dynamics, including localised, synchronised EV release. …
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ELECTROPHYSIOLOGICAL INVESTIGATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY IN DEAF-1 KNOCK-OUT MICE
… roles of both NMDA receptors and mGlu receptors (mGluR1 and mGluR5) were explored. Treatment with D-AP5 - a selective NMDAR antagonist on slices from control animals showed no effect on the baseline evoked responses, but LLTP was blocked following D - AP5 treatment. In slices from DEAF1 NKO …
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GROUP I METABOTROPIC GLUTAMATE RECEPTORS ON SELECTIVE CELLULAR SUBTYPES IN EPILEPTOGENIC MALFORMED CORTEX
… PMZ. There was an altered expression seen in PMZ mGluR1α labeled cells and cells in other cortical regions.</p>