NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 36 for “"mGluR"”.

  1. Effect of chemically induced mGluR-dependent long-term depression on dendritic spine volume

    Murphy, Alexander J. (Alexander James)Massachusetts Institute of Technology2010

    Based on extracellular field recordings and stimulations at the Schaeffer collateral-CA1 synapse, the synaptic tagging and capture (STC) model has hypothesized that at synapses that express any form of LTP and LTD (long-term potentiation and depression, respectively) are tagged in a protein …

    mit Repository record

  2. A Study on an FMRP-Mediated Translational Switch in the MGluR-Triggered Translation of Arc and Synaptic Plasticity

    Niere, Farr2012

    The group 1 metabotropic glutamate receptor (mGluR)-stimulated protein synthesis and long-term synaptic depression (mGluR-LTD) are altered in a mouse model of Fragile X Syndrome, Fmr1 knockout (KO) mouse. Fmr1 encodes the Fragile X mental retardation protein (FMRP), a dendritic RNA-binding protein …

    utswmed Repository record

  3. Ruolo dei recettori 5-HT7 per la serotonina nell'attività mitocondriale e nella fisiopatologia della sindrome del cromosoma X fragile

    TEMPIO, ALESSANDRAUniversità degli studi di Catania2022

    … dei recettori metabotropi per il glutammato (mGluR-LTD). Il nostro gruppo di ricerca ha precedentemente dimostrato che l’attivazione del recettore 5-HT7 per la serotonina reverte mGluR-LTD nell’ippocampo di topi wild-type (WT) e Fmr1 KO. Pertanto, durante il mio dottorato ho studiato alcuni …

    catania Repository record

  4. Analysis of the expression and effects of vascular endothelial growth factor family of molecules on Fragile X Syndrome abnormalities in a mouse model

    Belagodu, Amogh P.University of Illinois at Urbana-Champaign2017

    … products of the metabotropic glutamate receptor (mGluR) (mGluR Theory) (Bear et al., 2004). However recent clinical trials using mGluR inhibitors have all failed, attributing to various factors such as a need for optimized dosage, developmental time for intervention, better metrics for human …

    uiuc Repository record

  5. Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long Term Depression That Is Affected in Fragile X Syndrome

    Volk, Lenora Joanne2010

    … group I metabotropic glutamate receptors (mGluR1, mGluR5) induces long-term synaptic depression (LTD) that requires rapid, dendritic protein synthesis. The significance of protein synthesis-dependent mGluR LTD to cognitive function is highlighted by the recent finding that mGluR-dependent …

    utswmed Repository record

  6. Contributions of metabotropic glutamate receptors to the pathophysiology of autism

    Auerbach, Benjamin D. (Benjamin David)Massachusetts Institute of Technology2013

    … downstream of metabotropic glutamate receptor 5 (mGluR5) is a shared disruption in these disorders, and therefore may ultimately contribute to the pathophysiology of ASD in general. First, we show that multiple aspects of mGluR-mediated protein synthesis are altered in the mouse model of FX, …

    mit Repository record

  7. Role of Medial Prefrontal Cortical Group II Metabotropic Glutamate Receptor in the Development of Cocaine Sensitization

    Xie, Xiaohu2016

    … group II metabotropic glutamate receptors (mGluR<sub>2/3</sub>) in the development of cocaine sensitization. Initial studies demonstrated that intra-mPFC injection of the mGluR<sub>2/3</sub> receptor agonist, APDC, dose-dependently reduced acute behavioral response to cocaine (0.015-15 …

    tenn-hsc Repository record

  8. Synaptic plasticity in the MyosinVa mutant mouse

    Tunca, Cansu, 1977-Massachusetts Institute of Technology2009

    … of an RNA-binding protein into the spines upon mGluR activation [3]. We explored protein synthesis and mGluR-dcpendent LTD in flailer. The preliminary data we obtained show a transient impairment in mGluR.-LTD, suggesting a role for MyosinVa in protein synthesis dependent plasticity.

    mit Repository record

  9. THE GROUP II METABOTROPIC GLUTAMATE AGONIST, LY379268, DECREASES METHAMPHETAMINE SELF-ADMINISTRATION IN RATS

    Crawford, Jordan ThomasWake Forest University2011

    … Group II metabotropic glutamate receptor (mGluR) agonists are proposed to serve as an addiction treatment and have been shown to reduce the reinforcing properties of cocaine, but their efficacy has yet to be tested in METH. <italic>Objectives</italic>: The present study investigated the …

    wfu Repository record

  10. Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference

    Kathy Marie GenzerThe University of Texas Medical Branch2008

    … D (PLD) and metabotropic glutamate receptors (mGluRs), while other studies show an interaction between dopamine receptors (DRs) and PLD. Therefore, we investigated the mechanisms of the dopamine agonist-induced synaptic plasticity that is enhanced in the amygdala due to cocaine exposure in the …

    utmb Repository record

  11. Cellular and synaptic pathophysiology in a rat model of Fragile X syndrome

    Jackson, AdamThe University of Edinburgh2017

    … receptor mediated long-term depression (mGluR-LTD) in the hippocampus is both exaggerated (Huber et al., 2002) and independent of new protein synthesis (Nosyreva & Huber, 2006). These findings, together with studies focusing on other brain regions including the prefrontal cortex (Zhao et …

    edinburgh Repository record

  12. Social isolation enhances calcium signaling and synaptic plasticity in dopamine neurons of the ventral tegmental area

    Ramsey, Leslie AnneUniversity of Texas at Austin2012

    … augmentation of metabotropic glutamate receptor (mGluR)-dependent calcium (Ca²⁺) signaling via an increase in inositol 1,4,5-trisphosphate(IP3) sensitivity. Isolation-mediated effects on Ca²⁺ signaling and NMDAR plasticity were not reversed by a subsequent period of resocialization. Furthermore, …

    texas Repository record

  13. The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents

    Kady B. SchmidtThe University of Texas Medical Branch2007

    … that group I metabotropic glutamate receptor (mGluR) antagonists can block the induction of conditioned place preference (CPP), a measure of cocaine seeking behavior, but their functions after clinically relevant withdrawal periods are not known. Our study showed that group I mGluR antagonists …

    utmb Repository record

  14. The study of Murine double minute-2 (Mdm2) in regulating neuronal activity-dependent protein translation

    Liu, Dai-Chi (Debby)University of Illinois at Urbana-Champaign2020

    … Group 1 metabotropic glutamate receptors (Gp1 mGluRs). While multiple mechanisms have been identified that contribute to elevating local synaptic translation efficiency, it remains largely unknown how Gp1 mGluR-mediated signaling regulates general protein translation. We identified a novel …

    uiuc Repository record

  15. Cellular and Circuit Properties of Slow Oscillations In The Thalamic Reticular Nucleus

    O'Malley, John, <p>0000-0003-3774-1702</p>2020

    … Group 1 metabotropic glutamate receptors (mGluR) leads to long-lasting plateau potentials thought to be mediated by both T-type calcium currents and calcium-activated nonselective cation currents (I<sub>CAN</sub>). However, the identity of I<sub>CAN</sub> and the possible contribution of …

    uthsc Repository record

  16. Papel das reservas intracelulares de cálcio no efeito de aminoácidos excitatórios sobre a fosforilação da proteína ácida fibrilar glial (GFAP) em hipocampo de ratos jovens

    Oppelt, Daniela Mendes2002

    … glutamatérgico metabotrópico do grupo II (mGluR II), e pela ausência de Ca2+ externo (presença de EGTA). Entretanto, o tratamento simultâneo com glutamato e EGTA não resulta em efeito sinergístico, sugerindo um mesmo mecanismo de ação para estas duas situações estimulatórias da fosforilação …

    brazil-ufrgs Repository record

  17. An Examination of the Mechanisms of Neocortical Network Excitability in a Mouse Model of Fragile X Syndrome

    Hays, Seth Alanson2012

    … to the network hyperexcitation. Disruption of mGluR5 interactions with the scaffolding protein Homer, which results in consitituive mGluR5 signaling, is sufficient to prolong UP states. Futhermore, restoration of Homer-mGluR complexes in the Fmr1 KO reduces UP state duration to wildtype levels. …

    utswmed Repository record

  18. A Multi-Organ Role for Nocturnin in Post-Transcriptional Regulation of RNA

    Onder, Yasemin2020

    … from cortex and hippocampus. I investigated mGluR-LTD in hippocampal slices from Noc-/- and WT littermates and observed an attenuation of mGluR-LTD in Noc-/- mice in the first cohort, but this result was not replicated in a second cohort. Further studies are needed to elucidate Nocturnin's …

    utswmed Repository record

  19. Differential modulation of T-type voltage gated calcium channels by G-protein coupled receptors.

    Hildebrand, Michael EarlUniversity of British Columbia2008

    … acetylcholine (mAChR) or metabotropic glutamate (mGluR) GPCRs and individual Cav3 isoforms. Perforated patch recordings demonstrated that activation of Galpha<q/11>-coupled GPCRs had a strong inhibitory effect on Cav3.3 T-type Ca2+ currents but either no effect or a stimulating effect on Cav3.1 …

    ubc Repository record

  20. Synapse Dysfunction Induced by Autism Spectrum Disorder Associated Shank3 Mutations

    Lee, KevinResearchSpace@Auckland2015

    … (LTD), or metabotropic glutamate receptor (mGluR)-dependent LTD in neurons overexpressing Shank3, shRNA-Shank3 or ASD-associated mutant forms of Shank3. Neurons which lacked Shank3 or which expressed ASD-associated mutant versions of Shank3 displayed deficits in NMDAR-dependent LTP and …

    auckland-ms Repository record

Page 1 of 2