Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"mGlu5"”.
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Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain
Metabotropic glutamate receptor 5: mGlu5) has been suggested to play a role in the development and maintenance of chronic pain. mGlu5 is expressed at synapses throughout the pain neuraxis where it is believed to modulate the function of ion channels that underlie nociceptive transduction and …
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Dopamine Transporter (DAT) and Metabotropic Glutamate Receptor 5 (MGLU5) Irreversible Probes for Identifying Anti-Psychostimulant Therapeutics
… and metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) possess promising anti-addiction therapeutic properties. However, the lack of human DAT (hDAT) and mGlu5 X-ray crystal structures makes it difficult to understand how these promising anti-addiction …
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Modulation of Stress Granules formation: Role of mGlu5 receptor and FMRP and implications for pathophysiology of Fragile X Syndrome
… group-I metabotropic glutamate receptor, namely mGlu5; pharmacological blockade of mGlu5 receptors provide a therapeutic target in FXS. mGlu5 receptor, like FMRP, regulates protein synthesis but in a functionally opponent manner: mGlu5 receptor activates protein synthesis, FMRP suppresses it. In …
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Direct neuronal and microglia-mediated effects of group I metabotropic glutamate receptors in neurodegenerative and neuroinflammatory processes
… glutamate (mGlu) receptor, mGlu1 and mGlu5 receptors are involved in neurodegenerative and in neuro-inflammatory processes. We have examined the role of mGlu5 receptor in a neuroinflammatory context. This receptor is expressed in glial cells and has been reported to play an …
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Recettori purinergici ionotropi e i loro ruoli nella neuroinfiammazione mediata dalla microglia
… e il recettore metabotropico del glutammato mGlu5 è espresso in queste cellule, nella prima parte di questo progetto è stata studiata un'interazione tra questi due sottotipi di recettori. Inoltre, poiché è noto che gli steroidi neuroattivi svolgono un ruolo durante la neuroinfiammazione, …