Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"mAChR"”.
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The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently the target for 50% of all prescribed drugs. Cells …
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The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently the target for 50% of all prescribed drugs. Cells …
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The expression of muscarinc acetylcholine receptors on the avian vestibular hair cells and the modulation effects on KIR2.1
… receptors (nAChRs) and muscarinic receptors (mAChRs). Even though pioneering physiological and pharmacological studies have shown evidence of mAChR located on the HCs, the protein expression and the role of muscarinic acetylcholine receptor (mAChR) in HCs have not been carefully studied. Our …
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A neurophysiological and proteomic study of cognitive enhancing strategies
… of a new muscarinic acetylcholine receptor (mAChR) agonist that is selective for the M1 mAChR subtype, called 77-LH-281, has recently been achieved. 77-LH-281 binds to an allosteric site of the M1 mAChR which accounts for its increased selectivity over other mAChR agonists. This agonist …
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The M(1) muscarinic receptor and its second messenger coupling in human neuroblastoma cells and transfected murine fibroblast cells
… affinity muscarinic receptors (mAChRs) are coupled to the hydrolysis of inositol lipids and not to the adenylate cyclase system in human neuroblastoma SH-SY5Y cells. The maximal carbachol(CCh)-stimulated [³H]IP₁ accumulation in the SH-SY5Y cells was decreased in the presence of 1 …
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Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long Term Depression That Is Affected in Fragile X Syndrome
… shows that muscarinic acetylcholine receptors (mAChRs) activate protein synthesis in hippocampal CA1 dendrites. Data presented here demonstrate that PP-LFS activates both Gq-coupled mAChRs and mGluRs to induce LTD. Pharmacological activation of mAChRs induces LTD that requires rapid protein …
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Differential modulation of T-type voltage gated calcium channels by G-protein coupled receptors.
… interactions between muscarinic acetylcholine (mAChR) or metabotropic glutamate (mGluR) GPCRs and individual Cav3 isoforms. Perforated patch recordings demonstrated that activation of Galpha<q/11>-coupled GPCRs had a strong inhibitory effect on Cav3.3 T-type Ca2+ currents but either no effect or …
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Exploiting muscarinic acetylcholine receptors as an insecticidal target to enhance the toxicity of gamma-amino butyric acid channel blockers and the continued challenges with resistance
Muscarinic acetylcholine receptors (mAChRs) are G-protein-coupled receptors that are underutilized for controlling insect pests despite their involvement in various physiological functions. To-date, there are no commercialized insecticides targeting insect mAChRs. In this dissertation, effective …
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Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that mediate important functions in the periphery and in the central nervous systems. In the brain these receptors modulate many processes including learning, locomotion, pain, and reward behaviors. In this work we …
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Validation of an animal model of cognitive dysfunction associated with schizophrenia. Development and validation of the novel object recognition task using behavioural manipulations and psychotomimetic dosing regimens to induce cognitive deficits of relevance to schizophrenia in hooded-Lister rats.
… reveal that acute administration of the mAChR antagonist scopolamine, d-amphetamine, PCP and sub-chronic PCP treatment reduced working memory scores compared to vehicle treated controls. Taken together, these findings suggest that sub-chronic treatment with PCP induces cognitive deficits …
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Pharmacological studies on the contribution of the neuropeptide proctolin to the cephalic control of singing behavior in grasshopper Chorthippus biguttulus (L.1758)
Das artspezifische Gesangsverhalten der Feldheuschrecke Chorthippus biguttulus läßt sich sowohl bei Männchen als auch bei Weibchen durch Injektionen des Pentapeptids Proktolin in das zentrale Protozerebrum auslösen. Das stimulierte Verhalten entspricht bezüglich der seiner zeitlichen Struktur und …