Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"lysosomal protein"”.
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Non-lysosomal protein degrading systems in chicken skeletal muscle
… the ubiquitin-dependent and calpain pathways in protein degradation in chicken skeletal muscles, biochemical studies were conducted on components of these two systems as well as their potential endogenous and exogenous substrates. ATP- and ubiquitin-dependent breakdown of endogenous proteins …
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Non-lysosomal protein degrading systems in chicken skeleton muscle
… the ubiquitin-dependent and calpain pathways in protein degradation in chicken skeletal muscles, biochemical studies were conducted on components of these two systems as well as their potential endogenous and exogenous substrates. ATP- and ubiquity tin-dependent breakdown of endogenous proteins …
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Adrenergic control of proteolysis in brown adipocytes
… tissue atrophy by loss of cells, mitochondrial proteins, and uncoupling protein 1 (UCP1), the molecular basis for thermogenesis. The overall objective is to gain a better understanding of the control and the mechanisms underlying BAT atrophy. Specific objectives are: (1) whether in vivo patterns …
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A study on human IFIT3 modulation of IFIT1 protein stability
Interferon-induced proteins with tetratricopeptide repeats (IFITs) are expressed in both interferon-dependent and interferon-independent manners in cells after pathogen-associated molecular pattern recognition by the pathogen recognition receptors. Four IFITs (IFIT1, IFIT2, IFIT3 and IFIT5) have …
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Induction And Regulation Of Autophagy By Novel Prenylation Inhibitors In Sts-26t Malignant Peripheral Nerve Sheath Tumor (mpnst) Cells
… is the consequence of their action on the lysosomal trafficking of proteins. The compounds impaired procathepsin trafficking via the endocytic pathway along with degradation of the lysosomal protein, LAMP-2, which is required for autophagosome-lysosome fusion. These effects consequently …
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Regulation of neutrophilic inflammation by hypoxic signalling pathways
… The hypoxic lung represents a low glucose, high protein environment and neutrophils adapt to exploit this. I have shown that neutrophils can scavenge proteins from their extracellular environment, catabolise these proteins in the lysosome and utilise the breakdown products for metabolism. These …
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CD33 and TREM2 regulation of microglial functions
… by TREM2-dependent expression of cystatin F, a lysosomal protein upregulated during neurodegeneration. Such inhibition of phagocytosis could be detrimental in early AD by reducing clearance of Aβ plaques, but beneficial in later stages of AD by reducing phagocytosis of synapses and neurons. …
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Synaptic morphology, function, and regulation in a paediatric-onset neurodegenerative disorder
… within lysosomes as a result of dysfunctional lysosomal protein. The most common sub-group is mucopolysaccharidosis (MPS) III (collectively 1 in 70,000). In Australia, MPS IIIA is the most common sub-type and the focus of this study. MPS IIIA is caused by an autosomal recessive mutation in the …
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Funktionelle Analyse des murinen 66.3-kDa-Proteins
… stand das 2005 erstmals beschriebene murine lysosomale Matrixprotein 66.3-kDa-Protein. Die Interaktion des 66.3-kDa-Proteins mit der lysosomalen Aspartylprotease Cathepsin D, welche während der ausführlichen molekularen Charakterisierung vermutet wurde, konnte im Rahmen der vorliegenden …
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Structural characterization of the lysosomal 66.3 kDa protein and of the DNA repair enzyme Mth0212 by means of X-ray crystallography
… beinhalten. Abschnitt I befasst sich mit dem lysosomalen 66.3 kDa - Protein aus Maus, dessen zelluläre Funktion bislang nicht bekannt ist. In diesem Zusammenhang sind die erweiterte Anwendung zur Verfügung stehender kristallographischer Methoden sowie die anschließende Analyse der Struktur des …