Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"lysosomal dysfunction"”.
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Parkinson's Disease-Associated Protein VPS13C Regulates Phospho-Rab10-Mediated Lysosomal Function in Human iPSC-Derived Dopaminergic Neurons
… and identified an important role for VPS13C in lysosomal homeostasis. VPS13C-deficient neurons exhibited significantly enlarged lysosomes with increased inter-lysosomal contact sites and decreased organelle motility. Additionally, these neurons showed a decreased lysosomal hydrolytic capacity …
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Lysosomes and Ribonucleoprotein Dynamics in Neurons
… and nutrient sensing in the cell. Mutations in lysosomal enzymes and membrane proteins often result in neurological disease, demonstrating the critical role for this organelle in neuronal function and homeostasis. However, little is known about why diseases that impair this ubiquitous organelle …
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Identification of Cathepsin B and L as Novel Uva Targets Upstream of Cutaneous Lysosomal-Autophagic Dysregulation
… inactivation upstream of autophagic-lysosomal dysfunction. In human skin fibroblasts, exposure to noncytotoxic doses of chronic UVA (9.9 J/cm ², twice a week, 3 weeks) caused pronounced photooxidative impairment of cathepsin B and L enzymatic activity suppressed by antioxidant …
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The effects of the Parkinson’s disease-associated proteins LRRK2 and TMEM175 on the lysosomal profile of cultured mammalian cells under lysosomal stress conditions
Lysosomal dysfunction is increasingly recognised as a central factor in the development of Parkinson’s disease (PD). At least 11 out of the 24 PD-associated genes have been identified by genome-wide association studies (GWAS) to be involved in autophagy-lysosome pathways. Leucine-rich repeat kinase …
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The Role of Compartmentalized Metabolism in Cellular Metal Homeostasis
… performed on cells grown at sub-lethal levels of lysosomal pH inhibition identified several important metabolic pathways in this context. These included central carbon metabolism, cholesterol synthesis and iron homeostasis. While, cells starve for cholesterol and iron, only iron supplementation …
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Involvement of Gdap1 In The Regulation of Mtorc1 Activity In A Drosophila Mliv Model
<p>The master regulator of metabolism and growth, mechanistic target of rapamycin complex 1 (mTORC1), is responsible for maintaining metabolic homeostasis by sensing nutrient and energy levels within the cell to promote or inhibit translation and autophagy accordingly. In the childhood …