Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"lysine-specific demethylase 1"”.
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Crystal Structure and Mechanism of Lysine Specific Demethylase-1
<p>The reversible methylation of specific lysine residues in histone tails is crucial in epigenetic gene regulation. LSD1, the first known lysine-specific demethylase, selectively removes monomethyl and dimethyl, but not trimethyl modifications of Lys4 or Lys9 of histone-3. Here, we present the …
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Combined Inhibition of Lysine-Specific Demethylase 1 and Kinase Signaling as a Preclinical Treatment Strategy in Glioblastoma
… treatment options resulting in a poor prognosis. Lysine-specific demethylase 1 (LSD1) is overexpressed in glioblastoma and contributes to tumor growth and treatment resistance. Inhibitors of LSD1 have shown preclinical promise but have had limited clinical development for glioblastoma. Given the …
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Lysine Specific Demethylase-1 and the Brahma Chromatin Remodeling Complex Regulate Conserved Signaling Pathways During Drosophila Wing Development
… chromosomal deficiencies. I identified histone lysine demethylase enzymes as potential co-regulators of the Brahma complex and found that these demethylases were important for normal wing pattern development. Specifically, I identified Lysine Specific Demethylase-1 (LSD1) as a potential …
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Efforts to Elucidate the Binding Interaction between Lysine-Specific Demethylase 1 (LSD1/KDM1) and CoREST and Their Roles in Breast Cancer
… until the recent discovery of histone demethylases. Lysine specific demethylase 1 (LSD1) is a unique histone demethylase that removes methyl groups on lysine residues and mediates expression of many genes important in cancer progression. LSD1 activity and its substrate specificity are …
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TARGETING METABOLIC PLASTICITY OF GLIOBLASTOMA TUMOR INITIATING CELLS TO RESTORE SENSITIVITY TO LSD1-DIRECTED THERAPY
… genes' expression. We have recently shown that Lysine Specific Demethylase 1 (LSD1) genetic and pharmacological inhibition employing the selective LSD1 inhibitor (LSD1i) impairs TICs ability to restore homeostasis after ER stress or nutrient starvation by hindering a proper Activating …
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Pharmacological Inhibition of LSD1/KDM1A in Diffuse Midline Glioma Models and Impact on Kinase Signaling
… epigenetic modulators as promising cancer-specific targets emphasizing their potential as a novel therapeutic strategy. Epigenetic modulator, lysine specific demethylase 1 (LSD1) is a histone demethylase. It’s function demethylates mono- and di-methyl marks on H3K4 and H3K9 residues. This …
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Mechanisms and Targeting of Neurodevelopmental Regulator Rest In Medulloblastoma Dissemination
… through inhibition of epigenetic cofactor, lysine specific demethylase 1 (LSD1). To this end, I examined human MB patient samples for LSD1 expression and discovered that while CXCR4 signaling was highly relevant to SHH-beta subgroups, LSD1 was increased in the context of REST most strongly …
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Flavin Amine Oxidases from the Monoamine Oxidase Structural Family Utilize a Hydride Transfer Mechanism
… mouse polyamine oxidase (PAO) and human lysine specific demethylase (LSD1), to determine the mechanisms of amine oxidation. PAO is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the oxidation of N1-acetylated polyamines. The pH-dependence of the kcat/Kamine indicates …