Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"lysine demethylase"”.
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
Small cell lung cancer (SCLC) arises from neuroendocrine cells within the lung. Along with deletion or loss-of-function RB1 and TP53 mutations, which occur in almost all cases, subsets of SCLC are driven by specific lineage transcription factors including ASCL1, NEUROD1, POU2F3, or YAP1. The …
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Role of Histone Lysine Demethylase, KDM1B, in Trophoblast Stem Cell Self-Renewal and Differentiation
… imprints in the oocyte. KDM1B is a histone lysine demethylase whose activity is directed to H3K4me1 and H3K4me2, particularly within the gene body of actively transcribed genes. By generating CRISPR-Cas9-mediated knockout TSCs ablated for Kdm1b, I show that Esrrb is consistently …
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KDM4D Overexpression Enhances Cardiac Regeneration and Mitigates Myocardial Damage in Response to Ischemic Injury
… the field for decades. We recently reported that lysine demethylase KDM4D could partially prevent and reverse cell cycle gene silencing, resulting in modest adult cardiac myocyte proliferation. In this study, we examined the role of KDM4D in response to myocardial infarction in the clinically …
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Investigating the Role of the Lysine-Specific Demethylase 4C in Pancreatic Ductal Adenocarcinoma
… in pancreatic ductal adenocarcinoma (PDAC). Lysine demethylase 4C (KDM4C) is one of the chromatin modifying proteins frequently overexpressed across multiple solid cancers and is linked to chromatin instability, increased cell proliferation, and enhanced stem cell-like behavior. We observed …
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Postmitotic Dynamics in Chromatin Modification and Regulatory Topology Underlie Cerebellar Granule Maturation
… in the genomic distribution of histone H3 lysine 27 trimethylation (H3K27me3), demonstrating a causal function for this chromatin modification in gene regulation beyond its canonical role in cell fate specification. The developmental loss of H3K27me3 at promoters of genes that turn on as …
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Mathematical Modeling Reveals That G2/M Checkpoint Override
… of mitotic entry through regulating histone lysine demethylase KDM4B, which is required for the epigenetic regulation of key mitosis-related genes including <em>CCNB1</em> and<em> PLK1</em>.</p> <p>Given accelerated G2/M checkpoint recovery in TSC2-null cells with mTORC1 hyperactivity, we …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… of mitotic entry through regulating histone lysine demethylase KDM4B, which is required for the epigenetic regulation of key mitosis-related genes including <em>CCNB1</em> and<em> PLK1</em>.</p> <p>Given accelerated G2/M checkpoint recovery in TSC2-null cells with mTORC1 hyperactivity, we …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… of mitotic entry through regulating histone lysine demethylase KDM4B, which is required for the epigenetic regulation of key mitosis-related genes including <em>CCNB1</em> and<em> PLK1</em>.</p> <p>Given accelerated G2/M checkpoint recovery in TSC2-null cells with mTORC1 hyperactivity, we …
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Lysine Specific Demethylase-1 and the Brahma Chromatin Remodeling Complex Regulate Conserved Signaling Pathways During Drosophila Wing Development
… chromosomal deficiencies. I identified histone lysine demethylase enzymes as potential co-regulators of the Brahma complex and found that these demethylases were important for normal wing pattern development. Specifically, I identified Lysine Specific Demethylase-1 (LSD1) as a potential …
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Inhibition of KDM4 with QC6352 to Target High-Risk Neuroblastoma
… and identity of the cell. We showed that histone lysine demethylase subfamily 4 (KDM4) protein expression was higher in MYCN-amplified (MNA) NB cell lines and patient-derived xenografts (PDXs) compared with non-MNA counterparts. Additionally, genetic depletion of KDM4 correlated with reduced …
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CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION
Kdm6a is an X-linked gene encoding a lysine demethylase involved in epigenetic regulation of gene expression. It catalyzes the demethylation of histone H3 lysine-27, counteracting the function of Polycomb Repressive Complex 2 (PRC2). Kdm6a plays a key role in transcriptional activation of genes …