Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"lymphoproliferative disorders"”.
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Novel approaches to assess cellular interactions and their role in the pathology and treatment of lymphoproliferative disorders
Background: Migration and homing are essential to B-lymphocyte mediated immunity, and are driven by rapid, directed, and appropriate reorganisation of the actin cytoskeleton. Important observations have linked the cytoskeletal-rearrangements made by leukaemic B-lymphocytes of chronic lymphocytic …
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A novel genomics and bioinformatics approach to assess immunoglobulin and T cell receptor rearrangements and somatic hypermutation in lymphoproliferative disorders
… centres (GC). SHM has therefore been reported in lymphoproliferative disorders (LPDs) from GC origin. Strong prognostic links and clinical indications based on SHM status have been described in chronic lymphocytic leukaemia (CLL) were patients with mutated Ig present improved prognosis and longer …
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Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
… sarcoma. It is also associated with the B cell lymphoproliferative disorders, primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) and KSHV inflammatory cytokine syndrome (KICS). Existing research reveals that KSHV has developed numerous strategies to alter host cytokine …
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Il cane come modello animale spontaneo di patologie neoplastiche dell'uomo: ene Ataxia-Telangiectasia Mutated (ATM) Nnella predisposizione al cancro ed importanza dei riarrangimanti genici dei geni Ig/TCR per la diagnosi e prognosi delle malattie linfoproliferative
… and assessing minimal residual disease in lymphoproliferative disorders of dogs, are presented. The results of those molecular assay may be directly translated in the field of Veterinary practice as well as the may be used to improve our objective evaluation of new investigational drugs …
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Molecular genetics and functions of Kaposi's sarcoma-associated herpesvirus glycoproteins in viral entry and virus-induced cell fusion
… etiologic agent of Kaposi’s sarcoma and several lymphoproliferative disorders. Recently, the full-length KSHV genome has been cloned into a bacterial artificial chromosome (BAC) and successfully recovered in 293 cells. The herpesviral glycoproteins are structural components of the KSHV particle …
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KSHV Susceptibility and Transmission Within Tonsillar Specimens
… the early stages of development for KSHV lymphoproliferative disorders, hindering our ability to develop prophylactic measures or effective treatments. This dissertation will focus on the host and viral factors influencing the magnitude and dynamics of KSHV infection in the human tonsil to …
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Targeted therapies in mantle cell lymphoma
… MCL is one of the most difficult lymphoproliferative disorders to manage with a median survival rate of 43 months from diagnosis. The poor prognosis associated with MCL is due in large part to its late classification as a separate clinical entity leading to a dearth in available …
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Profilo molecolare dei linfomi post-trapianto
Fifty-two cases of monomorphic post-transplant lymphoproliferative disorders (M-PTLD), developed in patients undergone solid organ or bone marrow transplantation, were studied by the application of the tissue micro-array (TMA) technology. They included 50 cases of diffuse large B-cell lymphomas …
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Influence of Human and Viral IL-6 on KSHV Infection in Human Tonsil Lymphocytes
… designated KICS. Despite proven connections to lymphoproliferative disorders, little is known about how KSHV invades the human immune system or the early events governing infection in B lymphocytes. IL-6 signaling plays a critical role in KSHV-mediated disease, where elevated hIL-6 levels are …
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Effects of the Removal of Adherent and Phagocytic Cells on the Spleen Cell Lymphoproliferative Response of Tumor Bearing Mice
… with phytohemagglutinin as the mitogen. This lymphoproliferative response was quantitated using the Stimulation Index (SI). Spleen cells from mice injected with #51 cells, a chemically-transformed colon cell line, produced a SI value equal to that of normal mice. There was no evidence for …
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Seroepidemiological and Laboratory Diagnostic Studies on the Disease and Clinical Importance of Epstein–Barr Virus Infection // Сероепидемиологични и лабораторно диагностични проучвания върху разпространението и клиничната значимост на Epstein-Barr вирусната инфекция
Въпреки предположенията за ролята на вирусите в развитието на ракови заболявания у хората, първи доказателства се получават едва след асоциирането на лимфома на Бъркит (БЛ) с новооткрит херпес - подобен вирус, наречен на откривателите си Епщайн- Бар вирус (EBV). EBV е приет за първият човешки …
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Η ΑΝΑΓΕΝΝΗΤΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ ΚΥΤΤΑΡΙΚΩΝ ΠΛΗΘΥΣΜΩΝ ΛΕΜΦΑΔΕΝΩΝ ΣΕ ΛΕΜΦΟ-ΥΠΕΡΠΛΑΣΤΙΚΑ ΣΥΝΔΡΟΜΑ
ΜΕΛΕΤΗΘΗΚΕ, Η ΑΝΑΓΕΝΝΗΤΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ ΤΩΝ ΛΕΜΦΟΚΥΤΤΑΡΩΝ ΛΕΜΦΑΔΕΝΩΝ ΣΕ ΠΑΣΧΟΝΤΕΣ ΑΠΟ ΔΙΑΦΟΡΑ ΛΕΜΦΟΥΠΕΡΠΛΑΣΤΙΚΑ ΣΥΝΔΡΟΜΑ, Η ΔΙΑΚΡΙΣΗ ΜΕΤΑΞΥ ΤΩΝ ΔΙΑΦΟΡΩΝ ΛΕΜΦΟΥΠΕΡΠΛΑΣΙΩΝ ΒΑΣΕΙ ΙΔΙΟΤΗΤΩΝ ΠΟΛΛΑΠΛΑΣΙΑΣΜΟΥ ΤΩΝ ΚΥΤΤΑΡΩΝ ΚΑΙ ΑΝΑΖΗΤΗΘΗΚΕ ΣΥΣΧΕΤΙΣΗ ΜΕΤΑΞΥ ΑΝΑΓΕΝΝΗΤΙΚΗΣ ΔΡΑΣΤΗΡΙΟΤΗΤΑΣ ΚΑΙ ΠΡΟΓΝΩΣΗΣ ΣΤΑ …