Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"lymphopoiesis"”.
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
… for a strict separation of myelopoiesis and lymphopoiesis, not being the first lineage commitment step of HSCs.
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Expression and function of the αVβ5 integrin during human B lymphopoiesis
The integrin αVβ5 is a receptor for sCD23 molecule and the αVβ5-CD23 interaction sustains proliferation of the pre-B cell line SMS-SB. This thesis describes further investigation into the role of αVβ5 integrin during human B cell development. B cell development in the bone marrow involves stepwise …
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Old protein, new perspective : the role of Oct-1 during embryonic development and lymphopoiesis
B cell development consists of an ordered program of rearrangement and transcriptional events, leading ultimately to the expression of immunoglobulin (Ig) molecules. This process involves the interaction of cis acting elements with trans acting factors. The octamer element (5'ATGCAAAT-3') is …
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Comparative Studies of TSLP and IL-7 in Normal Early Human Neonatal and Adult B Cell Development
… subsequent stages of development. Adult B lymphopoiesis unlike CB B lymphopoiesis is IL-7– but may not be TSLP–dependent. We also used the expression of IL-7R, to identify a lymphoid progenitor that lacks myeloid potential. This information will be important in developing strategies for …
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Sex steroid hormones - roles in adaptive immunity and vascular pathology
… testosterone exerts its inhibitory effect on B lymphopoiesis in males by targeting the AR in osteoblasts while the thymic epithelial cells are a target for AR-mediated inhibition of T lymphopoiesis. A distinct regulation of peripheral B and T cell homeostasis may involve non-hematopoietic spleen …
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B Lymphocyte Development in Galt
… immunoglobulin genes. Unlike in other species, B lymphopoiesis in rabbit arrests a few months after birth, and it is unclear how the peripheral B cell compartment is maintained when there is no influx of newly-made B cells from the BM.</p><p>For my dissertation, I investigated how B cells develop …
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The endoplasmic reticulum chaperone ERdj4 is required for survival, glucose metabolism and B cell development
… the UPR is required for both early and late B lymphopoiesis, we hypothesized that ERdj4 deficiency would affect B cell development. Pro-B, pre-B, immature and mature B cell populations were significantly reduced in the bone marrow of ERdj4 gene trap mice in association with increased pro-B cell …
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Hematopoiesis: Functional Insights by Cell Fate Conversion
… with aging, including anemia and defects in lymphopoiesis. However, several hallmarks associated with HSC aging was lacking. In addition, the observed phenotypes appeared to result from alterations in progenitor cells rather than in HSCs. Thus, we concluded that mtDNA mutations are unlikely …
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Transcription, Editing, and Switching of Antibody Genes
… cells of the immune system. During B cell lymphopoiesis in the bone marrow, immunoglobulin molecules are assembled from V, D, and J gene segments through a process known as V(D)J recombination. Because of its stochastic nature, V(D)J recombination is expected to create self-reactive …
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
… characterize a novel role for GATA-3 during T-lymphopoiesis and cement Notch signaling as a key lineage-commitment factor.
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Investigation of the role of antagonism of the Interleukin-7 Receptor in the treatment of Multiple Sclerosis in Humans and In Vitro differences between genetically stratified subjects based on Interleukin-7 Receptor Genotype
… if palifermin could cause increased thymic lymphopoiesis, offsetting the IL-7 driven homeostatic proliferation of lymphocytes and secondary autoimmunity associated with alemtuzumab. Chapter 6 investigated the use of CD4+ lymphocytes as a biomarker for relapses after Alemtuzumab treatment. …
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Developmental Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Induced and Exacerbated Autoimmunity in Adulthood
… Prenatal TCDD also altered bone marrow B lymphopoiesis and B cell maturation and differentiation in the spleen. Functionally, these B cell changes resulted in high serum autoantibodies titers to dsDNA, ssDNA and cardiolipin suggesting a loss in central B cell tolerance. The functional …
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Part I characterization of MyoR in C2C12 mouse fibroblasts. Part II isolation and characterization of a novel class II bHLH transcription factor from the black widow spider, latrodectus hesperus
… of different developmental pathways, including lymphopoiesis, myogenesis, neurogenesis and sex determination. Screening a eDNA library prepared from silk-producing glands of the black widow spider, we have identified a new bHLH transcription factor named BW6. Within the bHLH region, BW6 shows …
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Studies on the Histone Methyltransferase G9a
… for T cell development. The defect in B lymphopoiesis in the absence of G9a is caused by a block in development at the pro-B cell stage, corresponding to the onset of immunoglobulin heavy chain recombination. The overall normal behavior of G9a-deficient peripheral B cells argues in favor …
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Identifying regulators of natural killer cell development through CRISPR screening of common lymphoid progenitors
… in this thesis adds to our knowledge of innate lymphopoiesis, with potential implications for how this might be distorted in systemic diseases such as cancer or targeted therapeutically.
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
… involved in lymphoid organ development, B cell lymphopoiesis, and myelopoiesis. In addition to regulating the noncanonical NF-kB pathway, NIK is also involved in regulation of kB dimers of the canonical NF-kB pathway and can function independent of NF-kB signaling by regulating lipid and glucose …
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Étude de la régulation de l'expression de PAX-5 et de ses isoformes dans le cancer du sein: implication des récepteurs d'oestrogène ERα et ERβ 3
… factor which plays a crucial role in B lymphopoiesis and whose deregulation has been associated to certain malignancies, namely non-Hodgkin lymphomas and acute lymphoblastic leukemia. Although Pax-5 is known to be expressed mainly in B cells, the brain during development and to a lesser …
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CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION
… in pre-B cells and later stages of B-cell lymphopoiesis. Kdm6a deficiency was dispensable for early B-cell differentiation but limited the re-entry of recirculating mature B cells into the bone marrow. Kdm6a-deficient mice exhibited a significant reduction in follicular B-2 B-cells in the …