Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"lymphopenia"”.
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Use of a conservation-of-linkage strategy to identify a candidate for the rat Lymphopenia gene
The rat Lymphopenia gene, Lyp, is absolutely required for the development of Insulin-Dependent Diabetes Mellitus (IDDM) in the BioBreeding (BB) rat. In order to overcome the lack of positional cloning resources available in the rat to clone the Lyp gene, we developed and successfully implemented a …
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Determining The Mechanisms Generating Soluble Il-15 Complexes
… of Interleukin (IL)-15. Additionally, inducing lymphopenia enhances anti-tumor responses in an IL-15-dependent manner. Paradoxically, despite the limited expression of IL-15 during homeostasis, the role of IL-15 during the steady state is well-known, while its roles during inflammation and …
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Effects of Daily Oral Injections of Quercetin on Implanted Colon-25 Tumor Growth in Balb-C Mice
… neutrophilia combined with a significant lymphopenia at day 20 post-implantation, and (3) there was relatively little evidence of histological changes in the quercetin-treated tumor section which would indicate that the action(s) of quercetin is primarily at the subcellular level probably …
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
… in response to homeostatic pressure, as in lymphopenia, naive T cells undergo proliferation without antigenic stimulation through a process referred to as lymphopenia-induced proliferation (LIP). LIP of naive CD8[superscript +] T cells requires IL-7 and a self peptide presented by MHC-I, …
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The Effects of Electrochemical Therapy on Colon-25 Tumors in Balb-C Mice
… counts showed a distinct neutrophilia and lymphopenia in all groups at day 20 post tumor implantation. The results from the experimental groups appeared to support the findings of previous investigators.
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ANALYSIS OF B LYMPHOCYTES IN MOUSE MODEL LIGASE IV WITH HYPOMORPHIC MUTATION IN VDJ RECOMBINATION ASSOCIATED WITH GROWTH DEFECT
… heterogeneous and may include varying degrees of lymphopenia, growth retardation and microcephaly. The phenotypic effects of the impaired repair of non programmed DNA damage are more diverse and difficult to study. Although such defects in cell survival and proliferation are likely to have an …
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Genetic Loci Contributing to Spontaneous Autoimmune Diabetes
… to express the Gimap5 protein is associated with lymphopenia (lyp) and linked to T1D in the BBDP rat. In an intercross between F1(BBDP x F344) rats we identified a rat with a recombination event on rat chromosome (RNO) 4, allowing us to fix 34Mb of F344 between D4Rat253 and D4Rhw6 in the congenic …
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… that severe flu infection results in significant lymphopenia, extracellular matrix remodeling, and transcriptional shutdown in fully immune-competent lung tissues. Lastly, we highlight the prominent role of stromal-immune interactions in the response to severe influenza infection, with stromal …
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Characterisation of physiological and immune-related biomarkers of weaning stress in beef cattle
… neutrophilia (increase in neutrophil number) and lymphopenia (decrease in lymphocyte number), reduced interferon-γ production, and increased concentrations of acute phase proteins were evident post weaning, whereas post-housing, changes were less marked. Weaning caused neutrophilia and impaired …
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Immunological evaluation of HIV-negative invasive fungal disease at Groote Schuur Hospital, Cape Town, South Africa
… immune work-up. A case of idiopathic CD4 lymphopenia was diagnosed; but all other cases had no evidence of neutrophil or a cell-mediated immune defect; including investigations of naïve and memory T-cell subsets and cytokine responses to PHA and candida. All cases were noted to have low …
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The ontogeny of the immune response to sheep erythrocytes and resistance to aflatoxins in chickens
… decreases in surface temperatures. Heterophilia, lymphopenia and reduced liver metabolism were observed at the 5697 ppb level. Although bursa and thymus weights were smaller in the aflatoxin-fed birds, there was no reduction in their SRBC antibody levels. The second experiment was designed to …
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Stress response and habituation as influenced by nutritional and thermal factors in dwarf and normal chickens
… was evaluated. In both stages, heterophilia and lymphopenia were noted and post-hatching heterophil to lymphocyte (H/L) ratios declined in a quadratic manner with age. Feed restriction elicited a similar stress response, as indicated by H/L ratios in dwarfs and normals with the effect of adapting …
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Molecular Mechanisms in Hematopoietic Stem Cell Aging
… of premature HSC aging including anemia, lymphopenia, and myeloid lineage skewing in mice that rapidly accumulate mitochondrial DNA (mtDNA) mutations. This however, was due to distinct differentiation blocks and/or disappearance of downstream progenitors in the absence of several hallmarks …
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In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia
… disorder with patients commonly showing lymphopenia and abnormalities in immunoglobulin production. They also have a high incidence of leukaemia and lymphoma at young ages. I used multicolour flow cytometry and immunological assays to characterise lymphocyte subsets in a group of 18 A-T …
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Development of Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spns2 for the Treatment of Multiple Sclerosis
… alternative approach to achieve S1P-mediated lymphopenia. In this dissertation, the design, synthesis, and activities of highly potent Spns2 inhibitors are disclosed. These structures spanned several scaffolds and culminated in the discovery of a phenylurea derivative 4.11i. In vitro …
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ATM Deficiency -- A Multifaceted Defect in Lymphocyte Development
… a syndrome characterized by lymphopenia, genomic instability and a predisposition to tumors involving antigen receptor loci suggesting that ATM likely plays a similar critical role downstream of Rag-mediated DNA DSBs during V(D)J recombination. In this body of work, I describe …
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Genetic association study of interleukin 6 receptor and liver X receptor in systemic lupus erythematosus
… of rash (p=0.037), leukopenia (p=0.033) and lymphopenia (p=0.027) were significantly higher in SLE patients having the haplotype HT2 [ATC]. In addition, we identified five polymorphisms (-1851 T>C and -1830 T>C in the promoter region, and -1003 G>A, -840 C>A and -115 G>A in the intron 1 …
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Characterization of Stress Responsive MicroRNAs and Their Roles in T Cell Development
… selection. This caused a peripheral T cell lymphopenia. Mzb1, NFATc3, and Camk4 were identified as novel miR-185 targets. Elevations in miR-185 enhanced TCR-dependent intracellular calcium levels, while a knockdown of miR-185 diminished these calcium responses. These effects concur with …
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Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction
… IL-15, stemming as a result of the post-HSCT lymphopenia and initial tissue damage induced by the pre-conditioning regiment. We found a dichotomy in the effect mediated by C3d. It decreased by 1.46-fold granzyme b production when used alone, but failed to sustain such effects when used in …
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Characterization of Influenza:Streptococcus pneumoniae synergistic disease and potential for disease alleviation via sphingolipid therapy
… treatment caused transient, but significant lymphopenia, influx of neutrophils and efflux of macrophages in the lungs, which was enhanced during a mild influenza infectionGene expression in the lungs was generally unaltered, but protein levels showed increases in specific influenza-induced …
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