Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"lymphomagenesis"”.
-
Integrative Genomics Reveals a Role for GNA13 in Lymphomagenesis
<p>Lymphomas comprise a diverse group of malignancies derived from immune cells. High throughput sequencing has recently emerged as a powerful and versatile method for analysis of the cancer genome and transcriptome. As these data continue to emerge, the crucial work lies in sorting through the …
-
The role of p53 in virus-induced and multi-step lymphomagenesis
… infection are weakly collaborative in T cell lymphomagenesis. The work described in this thesis aimed to investigate the role of p53 in MMLV-induced lymphoma and explore the basis of their relatively weak collaboration. The effects of p53 loss in combination with MMLV were explored first in …
-
The Role of an Ultraconserved Long Non-coding Rna in B-Cell Lymphomagenesis
<p>Ultraconserved regions (UCRs) are genomic segments with perfect (100%) conservation between the orthologous regions of human, rat, and mouse genomes. UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, …
-
Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL): Surplus to requirements or a protagonist in lymphomagenesis?
… cells in vivo by infection with MHV-ova prevents lymphomagenesis suggesting that the TCR is detrimental to tumour growth. Indeed, strong stimulation via the TCR of NPM-ALK-expressing primary T cells in vitro, impedes cell proliferation but cell growth is favoured when a weaker stimulus is …
-
Elucidating the functions of RNA helicases DDX3X and DDX3Y in normal and malignant B cells
… and DDX3Y in B cell development and MYC-driven lymphomagenesis. Using CRISPR-edited, isogenic lymphoma cell lines, I found that DDX3Y could compensate for loss of DDX3X to maintain translation and viability and that DDX3X deficient cells were entirely dependent upon DDX3Y for survival. By …
-
Dissecting the role of RNA helicase DDX3X in mRNA translation and B-cell function during immune responses
… affinity maturation and a common site of B-cell lymphomagenesis. Mutations in DEAD-box helicase 3X (DDX3X) have previously been found in B-cell lymphomas driven by the transcription factor MYC. Reduced DDX3X function buffers the effect of MYC on the upregulation of global translation, ultimately …
-
Genetic screens of RNA binding proteins identify a role for N6-methyladenosine in promoting B cell differentiation
… roles for RBPs in redox signalling, B cell lymphomagenesis, CD8 T cell activation, and B cell terminal differentiation. These identified over a dozen potential avenues of future investigation into the roles of RBPs in lymphocytes. I chose to further investigate the role of the RNA …
-
THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… Z-DNA binding protein (ZBP1) regulates B-cell lymphomagenesis. In summary, the data suggest pathogen recognition systems play a hitherto unknown role in tumorigenesis and immunosurveillance of cancer.
-
Functional analysis of KLF2 and its lymphoma-derived mutants
… loss in NF-κB suppression, which may promote the lymphomagenesis by facilitating differentiation of marginal zone B cells and their homing to the splenic marginal zone. We hypothesised that KLF2 may also modulate other pathways that are important in marginal zone B cell development, namely the …
-
Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
… evaluated the importance of Hif1α in T cell lymphomagenesis caused by PTEN deletion. These experiments identified the regulation of Hif1α expression as a critical step in the malignant transformation of PTEN-/- T cell progenitors. They also revealed that the metabolic changes that occur in …
-
Atm Signaling to Tsc2: Mechanisms and Implications For Cancer Therapy
… in <em>Atm</em>-deficient mice, which succumb to lymphomagenesis within 3-4 months of age with daily administration of rapamycin, could significantly extend survival and cause regression of tumors, suggesting that pharmacologically targeting this pathway has therapeutic implications in cancer.</p> …
-
Ldoc1, A Novel Biomarker of Prognosis In Chronic Lymphocytic Leukemia
… cell maintenance, lymphocyte development, and lymphomagenesis. Our findings indicate that LDOC1 mRNA is an excellent biomarker of overall survival in CLL, and may contribute to B-cell differentiation and malignant transformation.</p>
-
The Loss Of Genomic Uracil Homeostasis And Aid-Dependent Accumulation Of Dna Damage In B Cell Lymphomas
… mutations and translocations promoting lymphomagenesis. The introduction of uracils throughout the genome of activated B cells and the ability of UNG2 glycosylase to excise these uracils is examined here. This interplay was also studied in cancerous B cells, with different results …
-
Characterizing Chromosomal Aberrations in Cells Deficient for Both ATM and MSH2
… neurological defects, and spontaneous lymphomagenesis. <em>MSH2<sup>-/-</sup></em> mice suffer from aggressive lymphoid tumors between two to five months of age and have increased microsatellite instability, which predisposes <em>MSH2<sup>-/-</sup></em> mice to carcinomas. However, mice …
-
Understanding The Roles of Non-Homologous End Joining and P53 After Dna Damage
… of p53 in this system leads to aggressive lymphomagenesis. Therefore, to study the effect of p53-dependent cell cycle arrest, we utilized a hypomorphic, separation-of-function mutant, p53<sup>p/p</sup>, which completely abrogates apoptosis yet retains partial cell cycle arrest ability. We …
-
Anti-cancer effects of aqueous extracts of Dodonaea Viscosa on Burkitt lymphoma
… which is often altered in BL and known to drive lymphomagenesis, was found to mediate, at least partially, the cytotoxicity of DVE - the PI3K inhibitor p-PTEN was upregulated, leading to upregulation of its target p-PDK1. Additionally, the effector molecule p-AKT (ser 473) and p-GSK3 were …
-
The biological effects of HIV-1 Nef on the development of B-cell Lymphoma
… (Tat) and p17 in the progression of B-cell lymphomagenesis. Of particular interest to this study is the HIV-1 viral protein Nef (Negative Factor) which has been reported to have an oncogenic role in several cancer types including Kaposi's Sarcoma (KS) and Non-Small Cell Lung Cancer (NSCLC). …
-
Untersuchung zur Rolle von Notch1 in T-Zellentwicklung und Lymphomgenese
Notch Proteine gehören zu einer Familie hochkonservierter Transmembranrezeptoren, die bei Entwicklungsprozessen, beispielsweise im hämatopoetischen System, eine bedeutende Rolle spielen. So konnte eine Beteiligung von Notch und seinen Liganden bei der Differenzierung lymphatischer Zellen im …
-
Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling
… cooperate with antigenic stimulations during lymphomagenesis. The present thesis aimed to further elucidate the somatic genetic and immunogenetic profiles of primary thyroid lymphomas including EMZL, FL and DLBCL. In particular, the findings presented in this thesis help to improve our …
-
Strategies for Oncogenesis by Avian Leukosis Viruses
… can also lead to activation of c-myc and lymphomagenesis is discussed. One ALV-induced fibrosarcoma was obtained. This tumor produced a replication-defective rapidly transforming virus. The particular strain of ALV used was tdl07A, a transformation-defective mutant of subgroup A …