Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 357 for “"lymphoma"”.
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Investigating the genome of Anaplastic Lymphoma Kinase-positive Anaplastic Large Cell Lymphoma
Anaplastic Large Cell Lymphoma (ALCL) is a T cell Non-Hodgkin Lymphoma, mainly presenting in paediatric and young adult patients. The majority of cases express a chimeric fusion protein resulting in hyperactivation of Anaplastic Lymphoma Kinase (ALK) as the consequence of a chromosomal …
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The Biology of Mantle Cell Lymphoma: Exploring the Gender Difference in Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is a rare B cell neoplasm that accounts for approximately 4-8% of non-Hodgkin’s lymphomas (NHLs). The median age at diagnosis is 65 years with a male to female predominance of 3:1. It has also been demonstrated that female MCL patients have a greater response to therapy, …
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Molecular Pathogenesis of MALT lymphoma
Mucosa associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harbouring such translocation do not respond to Helicobacter pylori …
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Targeted therapies in mantle cell lymphoma
Mantle cell lymphoma (MCL) is characterized by the presence of the t(11 ;14)(g13 ;g32) translocation which results in cyclin Dl over-expression. MCL is one of the most difficult lymphoproliferative disorders to manage with a median survival rate of 43 months from diagnosis. The poor prognosis …
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MYC-DEPENDENT TRANSCRIPTIONAL CONTROL IN HUMAN LYMPHOMA
… the oncogenic MYC allele of three human B-cell lymphoma cell lines, thus directing expression of a conditionally degradable MYC-AID fusion protein. Treatment of the cells with Auxin caused an immediate MYC-AID drop, resulting in gradual proliferative arrest and cell death. While residual MYC-AID …
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Understanding the molecular pathogenesis of HIV-associated Burkitt Lymphoma – the impact of HIV-1 protein Tat on lymphoma driver genes
Burkitt Lymphoma (BL) is a B cell non-Hodgkin lymphoma that occurs as three distinct subtypes, namely: endemic, sporadic, and immunodeficiency/HIV-associated. This cancer represents a frequent cause of mortality among HIV+ people in Southern Africa which has the highest incidence of HIV/AIDS …
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Leukemia/Lymphoma Related Factor in Human Prostate Carcinoma
… pathogenesis of BPH and PC are unknown. Leukemia/lymphoma related factor (LRF)/ Pokemon (POK erythroid myeloid ontogenic factor) is a newly discovered transcription factor. It is a 72 kDa zinc-finger protein encoded by the ZBTB7A gene, which resides in the 19p13.3 locus. LRF/Pokemon belongs to POK …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… organisms from cancer. We discovered that B-cell lymphomas and many tumor cell lines of various origin constitutively express cytosolic DNA as a consequence of drug- or oncogene-induced nuclear DNA damage. The expression of cytosolic DNA correlated with the activation of IRF3, suggesting that …
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Hodgkin's Lymphoma survivors' intentions to follow survivorship care plans
… and perceived behavioral control that Hodgkin's Lymphoma (HL) survivors had towards survivorship care plans (SCPs) and how those factors impact their intentions to follow a care plan. Participants were HL survivors who had completed treatment. An online self-reporting questionnaire was used to …
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Cytogenetic and molecular analysis of follicular non-Hodkin's lymphoma
… translocation t (14;18)(q32;q21) in follicular lymphoma varies from 50% to 90% in American series. In the largest series from Europe, the translocation was present in only 21/51 (41%) of cases. The wide variety in incidence may in part be due to the method of detection used - usually …
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Functional analysis of KLF2 and its lymphoma-derived mutants
Splenic marginal zone lymphoma is a low-grade B cell neoplasm, which originates from the splenic marginal zone B cells. Whole exome studies show recurrent somatic mutations in KLF2, and genes in the NOTCH2, NF-κB, BCR and TLR signalling pathways – pathways that are essential for the development and …
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Engineering delivery systems for the treatment of Non-Hodgkin lymphoma
… cancers, including various leukemias and lymphomas, are among the top 10 cancers diagnosed in people. The leukemia and lymphoma society estimates that there are nearly 1.7 million people in the United States living with or in remission from hematological cancers. The frontline therapeutics …
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Automated Analysis of Flow Cytometry Data for B-Cell Lymphoma
… of hematolymphoid malignancies including B-cell lymphomas, is an innovative technique that measures the fluorescence of suspended cells. Traditionally, the method of evaluating the research and clinical study of flow cytometry data is done by the process of manual gating along with a review by …
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Investigating the Genomics and Heterogeneity of Childhood Non-Hodgkin Lymphoma
The commonest childhood Non-Hodgkin Lymphomas (NHLs) form three major categories: the aggressive mature B-cell NHLs including Burkitt lymphoma (BL), Anaplastic Large Cell Lymphomas (ALCL), and lymphoblastic lymphomas. Most childhood NHL is high-grade and generally responds well to high-intensity …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
Anaplastic Lymphoma Kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is a T-cell non-Hodgkin lymphoma characterised by a chromosomal rearrangement [t(2;5) (p23;q25)] involving the ALK and NPM1 genes on chromosomes 2 and 5 respectively. This translocation generates the NPM-ALK fusion …
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Hdm2 Small-Molecule Inhibitors For Therapeutic Intervention In B-Cell Lymphoma
<p>Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, compromising p53 activity. Therefore, lymphoma is a suitable model for studying therapeutic value of disrupting HDM2-p53 association by small-molecule inhibitors (SMIs). HDM2 SMIs have been developed and are currently …
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Multilevel Deregulation of Survival Mechanisms In Npm-Alk+ T-Cell Lymphoma
<p>The anaplastic lymphoma kinase (ALK) is a single chain transmembrane receptor tyrosine kinase that belongs to the insulin receptor superfamily. Other members of this superfamily include the insulin receptor (IR), type I insulin-like growth factor receptor (IGF-IR), and the leukocyte tyrosine …
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