Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"lymphocyte activation"”.
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Molecular Mechanisms of Lymphocyte Activation - Please Mind the Gap
The underlying mechanism of lymphocyte triggering is still not fully understood, but the kinetic-segregation (KS) model of receptor triggering in T cells has been supported by several recent studies. This model proposes that the small gap between an antigen-presenting cell and an immune cell …
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Analysis of B lymphocyte activation and differentiation by expression profiling
B cell development is severely impaired in the absence of SLP65 adaptor protein. SLP65-deficient B cells are arrested at the large cycling pre-B cell stage in the bone marrow and transitional B cell stages in the spleen of mice. The zinc-finger transcription factor EGR1 is an immediate early gene …
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Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection
… <p>RAMAN SPECTROSCOPIC MODELING OF T-LYMPHOCYTE ACTIVATION AND DETECTION OF ACUTE RENAL ALLOGRAFT REJECTION</p> <p>By</p> <p><strong>KRISTIAN L. BROWN</strong></p> <p>2010</p> <p>Advisor: Gregory Auner, PhD</p> <p>Major: Biomedical Engineering</p> <p>Degree: Doctor of Philosophy</p> …
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Lymphocyte Activation, T-Cell Cytotoxicity and Their Relationship to Dietary Fat Enhanced Murine Mammary Tumorigenesis
… on mammary tumorigenesis, mitogen-induced lymphocyte blastogenesis, cell-mediated cytotoxicity, and serum and lymphocyte fatty acid composition in C3H/OUJ female mice. Weanling mice fed 20% SBO for nine months had a higher incidence (89 vs. 65%) and greater average size (2.9 vs. 1.9 g) of …
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
… of cellular tolerance and homeostasis. T lymphocytes need to undergo processes of development, differentiation and activation in order to perform their functions, and for this purpose, they express the TCR receptor in their membrane, which upon activation triggers a very complex …
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Design of Antigen-Specific Immunotherapies Through Modulation of Peripheral Tolerance Pathways
… ability to respond to foreign pathogens. Lymphocyte activation is dependent on receiving two signals in tandem: interaction with the antigen of interest and co-stimulatory signals. Disruption of this two-signal model for lymphocyte activation in the context of the autoantigen is key to …
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The effects of hyaluronic acid and exercise on equine skeletal muscle
… in horses down regulated genes associated with lymphocyte activation and cytokine production (Il17RA, OSCAR, LYL1, TLR1, TLR2, TLR8, TLR10) but did not irreversibly down regulate these genes with the addition of exercise. Exercise as a stressor did cause an acute inflammatory response in muscle …
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TRIM22/Staf50 - a novel target gene of the tumor suppressor p53
… a role in hematopoietic differentiation and in T lymphocyte activation. Given that TRIM22 mediates cell death and has a role in differentiation and viral defense, I suggest that TRIM22 could be the link between p53 tumor suppression pathways and interferon response pathways. However, further …
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Influence of Anti-CD44 on Murine B Cell Activation
Lymphocyte activation and trafficking are indispensable to the immune system. CD44, an adhesion molecule, plays important roles in T cell activation, lymphocyte homing/trafficking, and tumor metastasis. Although the functions of CD44 have been shown in T cells and other leukocytes, little is known …
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Zinc Finger Protein 36L1 (ZFP36L1): Gene Expression, Regulation and Interactions with Immune Receptors in Human Tumour Cells.
… as of the adhesion receptor CD44 involved in lymphocyte activation, haematopoiesis and tumour metastasis. In this study we also report data on the detection and quantification of ZFP36L1 in several tumour cell lines such as THP1, Jurkat, B16, MCF7, and MC38. To study the function of ZFP36L1 a …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… BDNF, neurofilament light chain, and CD8+ lymphocyte activation (CD38+ HLADR+). Alzheimer's Disease (AD) biomarkers included soluble amyloid precursor protein alpha and beta (sAPPα/β), Aβ38, 40, 42, and ten other biomarkers validated as predictors of mild cognitive impairment and …
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Study of the HIV-1 Gene Regulatory Proteins TAT and REV by the Two-hybrid System in Yeast
… (including neurotoxicity and inhibition of lymphocyte activation) which may be extraneous to its viral functions.</p> <p>In order to identify cellular proteins interacting with Tat and Rev, the genes for both were cloned into plasmid vectors of the yeast two-hybrid system. This system …
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Stem cell-based regenerative pharmacology for the treatment of diabetes mellitus
… properties and are able to inhibit lymphocyte activation by release of soluble factors in vitro. This quality makes AFS cells an ideal candidate for cell-based immunomodulation in early stages of T1DM to prevent the autoimmune response or in combination with allogeneic islet …
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Cofilin
… cytoskeleton which is highly relevant for T lymphocyte activation. Cofilin is regulated in its activity by reversible phosphorylation which is inducible by stimulation through accessory receptors such as CD2 and CD28. First it could be demonstrated that accessory receptor triggering induces …
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Vaccinia Virus-Mediated Glioma Gene Therapy Using p53, IL-2 and IL-12
… gliomas in athymic mice (associated with NKT lymphocyte activation in the spleen and IFN-γ and TNF-α induction in the tumor) was achieved at a low dose of cytokine carrying vectors (100 PFU, plaque forming units), some mice exhibited adverse cytokine effects. However, combining this …
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Mechanisms Underpinning Functional Resident Humoral Lung Immunity
… broadly reactive antibodies. CD69 is an early-activation marker which is understood to be upregulated rapidly upon lymphocyte activation and can promote tissue-retention of T cells. I hypothesise that CD69 has a role in ectopic germinal centre function and tissue-resident memory B cell …
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RNA Dynamics in T Cell Activation
… adaptive immune responses. We have studied human lymphocyte activation as a model for correlating changes in RNA regulation with dynamic cellular state changes and stress responses. We hypothesize that RNA-binding proteins such as Argonaute (Ago) and HuR play critical roles in shaping the dynamic …
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