Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 584 for “"lymphocyte"”.
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B Lymphocyte Development in Galt
<p>In rabbits, the primary antibody repertoire is generated in the gut-associated lymphoid tissues (GALT), where bone marrow (BM)-derived B cells undergo a proliferative expansion and somatically diversify the immunoglobulin genes. Unlike in other species, B lymphopoiesis in rabbit arrests a few …
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Phosphorylation Regulation of T-Lymphocyte Migration
<p>Immune surveillance requires efficient trafficking of leukocytes throughout the body. To achieve this, leukocytes have evolved to be highly migratory and responsive to environmental cues, which provide guidance for proper tissue distribution. The translation of external environmental cues to …
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Spontaneous lymphocyte transformation in Hodgkin's disease
Contains fulltext : mmubn000001_026634295.pdf (Publisher’s version ) (Open Access)
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Anthrax toxin effects on B lymphocyte function
… toxins on the adaptive immune response, B lymphocytes were exposed to LeTx or EdTx in vitro. LeTx and EdTx both inhibit B cell activation in different manners. LeTx inhibited B cell proliferation but not migration, while EdTx inhibited B cell migration but not proliferation. LeTx and EdTx …
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Lymphocyte-Macrophage interactions and resistance to Toxoplasmosis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Cytotoxic T lymphocyte biology under the microscope
Cytotoxic T lymphocytes (CTLs) are essential agents of the adaptive immune system that seek out and destroy virally infected or cancerous cells. Incapacitate them and you become severely immunocompromised and riddled with tumours (à la prf1-/- mouse model); enhance them and you can beat previously …
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Lymphocyte subset variability between human lymphoid tissues
Most adaptive immune lymphocytes are in the lymphoid tissues. However, studies of human lymphocytes to date have primarily investigated cells from the blood, and lymphoid tissues remain poorly studied. This thesis explores the hypothesis that there is local variation of B cell subsets between the …
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ATM Deficiency -- A Multifaceted Defect in Lymphocyte Development
… a functional antigen receptor gene in developing lymphocytes requires that the second exon be assembled through a process known as V(D)J recombination, a process that necessarily involves the generation and repair of DNA double-strand breaks made by the Rag endonuclease. Double strand breaks …
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Role of T Lymphocyte Trafficking in Diabetic Cardiomyopathy
… an active area of research. Notably, increased T lymphocyte infiltration into myocardium has been attributed to increased cardiac fibrosis and dysfunction in diabetes. However, the experimental data on the role of T lymphocyte modulation in diabetic myocardial fibrosis is scarce. To this end, …
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The scaffold protein POSH regulates T lymphocyte function
T lymphocytes are critical mediators of the adaptive immune response. T cell receptor (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, little is know as to how JNK activation is coupled to the TCR. This dissertation …
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Stimulus-Mitosis Coupling in the Rat Thymic Lymphocyte
… the entry of normally quiescent rat thymic lymphocytes into the cell division cycle. This study has investigated the events which follow signal presentation and which culminate in cell cycle entry. The initial experiments examined mitotic activity in cultured thymocytes exposed to mitogenic …
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Stimulus-Mitosis Coupling in the Rat Thymic Lymphocyte
Quiescent thymocytes are stimulated to divide by a variety of compounds. These may be subdivided into four categories. The first group includes parathyroid hormone, vitamin D3 and its metabolites and raised extracellular calcium concentrations. Enhanced calcium influx provoked directly or possibly …
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Antigen Recognition by an Alloreactive T Lymphocyte Clone
In chapter two, the ability of CTL 2C to recognize thiol-modified peptide variants is analyzed. A method for the synthesis and screening of thiol-modified peptides that are recognized by T cells is presented. Chapter three continues the peptide variant approach with examination of the ability of …
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Nucleic acid changes during lymphocyte transformation in vitro
Circulating blood lymphocytes (a) do not usually divide in vitro (Trowell,1965), and (b), are of importance in immunity (Gowans + McGregor,1965). Nowell in 1960 discovered that when a bean extract, PHA, was added to these cells in culture they were suddenly activated to transform and divide. …
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T-lymphocyte senescence and hepatitis C virus infection
… efficacy of adaptive immune system function. T-lymphocytes from aged subjects demonstrate multiple phenotypic and functional changes, including telomere shortening. Short telomeres are associated with poor proliferative capacity, pro-inflammatory responses and increased mortality in clinical …
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Microfluidic single-cell technologies for assaying lymphocyte interactions
… these features enable monitoring and assaying lymphocyte interactions longitudinally from the beginning with multiparametric single-cell measurements. These capabilities in turn allow probing into complete immune cell activation window from the very onset for direct correlation analyses within …
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Alterations in lymphocyte signalling produced by exposure to mercury
The effects of 1 min – 4 hr exposures to mercuric chloride (HgCl2), methyl mercuric chloride (CH3HgCl), p-chloromercuribenzoate (p-CMB) and ethylmercurithiosalicylate (TMS) on cell viability and kinetics of cell death, microtubules, F-actin, CD3 receptor expression, protein tyrosine phosphorylation …
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Characterization of Antigen Recognition by a T Lymphocyte Clone
Chapter Four addresses the physiological T cell responses that can be elicited by peptide/MHC recognition. We demonstrated that the endogenously derived peptide, dEV8, functioned as both an agonist and an antagonist of T cells derived from 2C TCR transgenic mice. Although the exact mechanism …
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