Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"lymphoblastoid cells"”.
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The genomic anchors of the human major histocompatibility complex
… fibroblasts, IFN-γ induced fibroblasts and B lymphoblastoid cells. Expression array analysis showed that these cell types exhibit different MHC expression profiles. MARs were first isolated treating nuclei with hypertonic buffers followed by nuclease digestion and then mapped by hybridizing …
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Transcription Factor Binding Dynamics and Spatial Co-localization In Human Genome
… resolution Hi-C contact map of human GM12878 lymphoblastoid cells, we investigated computationally the genome-wide spatial co-localization of transcription factor binding sites, for both within the same type and between different types. First, we observed a strong positive correlation between …
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Monoallelic Gene Expression In Human Neural Stem Cells
… evidence of widespread autosomal RME in human lymphoblastoid cells (Gimelbrant et al. 2007) and mouse neural stem cells (Wang et al.2010; Li et al. 2012). However, the extent to which RME occurs in human neural tissue is unknown. Using a genome-wide analysis of allele-specific expression in …
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Involvement of microRNAs and their targeted genes in the pharmacogenomics of lithium response in bipolar disorder: a genome wide study
… a Next Generation Sequencing (NGS) approach. Lymphoblastoid cells lines (LCLs) derived from 20 BD patients, 10 Full Responder (FR) and 10 Non-Responder (NR) to chronic lithium treatment according to the “Retrospective Criteria of Long - Term Treatment Response in Research Subjects with Bipolar …
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Understanding cell fate decisions in response to 0⁶-Methylguanine DNA lesions
… diseases. To combat these threats, eukaryotic cells activate a DNA damage response (DDR) that coordinates a wide variety of cellular processes including cell cycle progression, DNA repair, or in the case of severe/irreparable damage, apoptotic cell death. In addition to its role in cancer …
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The role of cardiolipin in the regulation of mitochondria-dependent apoptosis
… of CL in apoptosis. Using BTHS patients-derived lymphoblastoid cells and HeLa cells in which tafazzin was stably knocked-down using RNA interference, this study provides the first evidence that mature CL are required for an efficient extrinsic apoptotic pathway in type II cells. Further …
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Studies on the Complement Receptor of a Human Lymphoblastoid Cell Line
<p>A human lymphoblastoid cell line, 8866, was used to investigate a surface marker, the C3d receptor. A method for cloning these cells at a relatively high efficiency was developed and C3d receptor bearing (CR+) and receptor free (CR-) subclones isolated. Receptor bearing cells were identified by …