Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"lymphatic vasculature"”.
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Engineering three-dimensional lymphatic vasculature on-chip through biochemical and mechanical stimulus
… the generation of physiologically relevant 3D lymphatic capillaries. This tissue engineering platform allowed us to probe the vascularization dynamics of lymphatic endothelial cells under a highly controlled microenvironment and isolate the effects of biochemical and biophysical inputs. Under …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
The lymphatic vascular system is necessary for physiological regulation of tissue fluid homeostasis and absorption of dietary fat. Lymphatics also function in the inflammatory response and are involved in pathological conditions such as wound healing and cancer. We show that the Notch signaling …
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Utilising zebrafish as a model to investigate lymphangiogenesis and its contributions to disease
Lymphatic vessels play an important role in the regulation of tissue fluid homeostasis, immune surveillance and dietary fat absorption. In addition, aberrant lymphatic development is associated with tumour metastasis and forms of chronic inflammation such as inflammatory bowel disease (IBD). …
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Investigating lymphatic vascular remodelling during postnatal mouse mammary gland morphogenesis.
The lymphatic vasculature, an essential component of the cardiovascular system, serves several functions critical to embryonic development and adult homeostasis. Lymphatic vessels return interstitial protein-rich fluid to the bloodstream, transport immune cells during immune surveillance and …
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The functional and remodeling response of collecting lymphatic vessels to disruption of lymphatic drainage pathways
The lymphatic system is composed of a network of vessels, nodes, and accessory organs that is present in most soft tissues of the body. The lymphatics play a vital role in maintaining tissue fluid homeostasis, trafficking immune cells from the periphery to the nodes, and transporting dietary lipids …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
The lymphatic vasculature is a key player in progression of many cancers, with lymphangiogenesis at the primary tumour and tumour-draining lymph nodes (TDLNs) associated with poor patient prognosis. As well as providing a highway for metastatic tumour cells, recent reports propose lymphatics as …
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On-Chip Engineered Human Lymphatic Microvasculature for Physio-/Pathological Transport Phenomena Studies
In addition to the blood vasculature, the majority of tissues contain a secondary vascular system known as the lymphatics that supports tissue homeostasis and immune cell trafficking. As such, impairment of the lymphatic capillaries can result in diverse diseases including abnormal tissue swelling …
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Integrated Multimodal Analysis: Evaluating the Impacts of Chemotherapy and Electroporation-Based Therapy on Lymphatic and Blood Microvasculature in Cancer
The lymphatic and blood vascular systems are two important vessel networks that serve different roles in healthy states and in cancer. In breast cancer the most common cancer amongst women, mortality remains high despite increased treatment response due to metastatic spread, preferentially through …