Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 140 for “"lymphatic"”.
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Lymphatic pathophysiology of tumors
… on cancer survival, but the mechanisms for lymphatic metastasis are not well understood. The universal finding in solid tumors of an absence of functional lymphatic vessels seems paradoxical, as cancer cells do travel through lymphatics in order to disseminate. In order to address some of …
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Interstitial-lymphatic transport phenomena
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1998.
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The functional and remodeling response of collecting lymphatic vessels to disruption of lymphatic drainage pathways
The lymphatic system is composed of a network of vessels, nodes, and accessory organs that is present in most soft tissues of the body. The lymphatics play a vital role in maintaining tissue fluid homeostasis, trafficking immune cells from the periphery to the nodes, and transporting dietary lipids …
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Computational Investigation of Lymphatic Valves and Vessels
The lymphatic system transports macromolecules and fluids throughout the body via contractions of lymphatic vessels. This flow from vessel contractions is regulated by unidirectional lymphatic valves, which allow lymphatic pumping against adverse pressure gradient. Despite the importance of the …
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Vanishing Act: Lymphatic Vessels and Disappearing Bones
Generalized lymphatic anomaly (GLA) and Gorham-Stout disease (GSD) are related diseases of the lymphatic system. Patients with GLA or GSD develop ectopic lymphatic vessels in bone and gradually lose bone. Despite growing interest in the development of tissue-specific lymphatics, the cellular origin …
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Characterization of endothelial cells of lymphatic vessels
… cells form the inner lining of blood and lymphatic vessels. In mice only tumours of the blood vessel endothelium (haemangiomas) have been thus far reported. In the first part of this thesis is described a highly reproducible method for the induction of benign tumours of the lymphatic …
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MECHANICALLY MEDIATED GROWTH AND REMODELING OF COLLECTING LYMPHATIC VESSELS
Lymphatic dysfunction plays a key role in pathologies such as immune disorders, infection, cancer, obesity, and cardiovascular disease; regarding the latter, lymphatic dysfunction may exacerbate edema in myocardial infarction (MI) and chronic heart failure. Secondary lymphedema is a progressive and …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
The lymphatic vascular system is necessary for physiological regulation of tissue fluid homeostasis and absorption of dietary fat. Lymphatics also function in the inflammatory response and are involved in pathological conditions such as wound healing and cancer. We show that the Notch signaling …
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Investigating lymphatic vascular remodelling during postnatal mouse mammary gland morphogenesis.
The lymphatic vasculature, an essential component of the cardiovascular system, serves several functions critical to embryonic development and adult homeostasis. Lymphatic vessels return interstitial protein-rich fluid to the bloodstream, transport immune cells during immune surveillance and …
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Minimally invasive assessment of lymphatic pumping pressure using near infrared imaging
Although the major functions of the lymphatic system are fairly well defined, its vasculature has yet to be well characterized in comparison to its blood vasculature counterpart. Recent advances in optical imaging techniques have allowed for more detailed and quantitative evaluations of lymph flow …
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The membrane, interstitium, lymphatic system : a model of lung water dynamics
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology Program in Medical Engineering and Medical Physics, 1984.
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
Lymphatic vessels play a crucial role in both the pathophysiology of tumors and in the spread cancer cells to lymph nodes. The effects of radiation on these vessels, however, are largely unknown. Here, we seek to describe the effects of ionizing radiation on normal and tumor-associated lymphatic …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… can occur through the bloodstream or lymphatic system. The presence of tumour cells in the draining lymph node (lymph node involvement) represents the most important prognostic factor for breast cancer patients. Despite its clinical implications, the mechanisms governing lymphatic …
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On-Chip Engineered Human Lymphatic Microvasculature for Physio-/Pathological Transport Phenomena Studies
… contain a secondary vascular system known as the lymphatics that supports tissue homeostasis and immune cell trafficking. As such, impairment of the lymphatic capillaries can result in diverse diseases including abnormal tissue swelling (edema), compromised immunity and cancer metastasis. Current …
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Engineering three-dimensional lymphatic vasculature on-chip through biochemical and mechanical stimulus
… the generation of physiologically relevant 3D lymphatic capillaries. This tissue engineering platform allowed us to probe the vascularization dynamics of lymphatic endothelial cells under a highly controlled microenvironment and isolate the effects of biochemical and biophysical inputs. Under …
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Engineered models of the lymphatic stroma to study cell and fluid transport
The lymphatic system plays essential roles in regulating fluid balance and immunosurveillance. Across the body, local lymphatic vessels collect waste in the form of lymph and deliver it to nearby lymph nodes (LNs) to be filtered and screened for pathogens. With broad implications in adaptive …
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CELLULAR MRI: TRACKING THE MIGRATION OF METASTATIC CANCER CELLS IN THE LYMPHATIC SYSTEM
The role of the lymphatics as a mode of tumor cell transport has been known for some time, and remains of critical importance since a majority of cancer deaths result from metastatic dissemination away from the primary tumor. In the studies performed in this thesis novel cellular MRI technology and …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
The lymphatic system is a network consisting of lymphatic vessels and lymphoid organs such as lymph nodes (LNs), which drain excess interstitial fluid and eventually return it to the blood circulatory system via the thoracic duct and subclavian veins. It plays a key role in interstitial fluid …
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The intraorgan lymphatic system of the rat left ventricle in normalcy and aging
Intracardiac lymphatic vessels of the rat heart left ventricle were studied quantitatively at the ultrastructural level in order to establish baseline morphometric data and also to assess age-related variability in the accepted visible macromolecular transport pathways. Lymphatic vessels were found …
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