Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"lymph node metastases"”.
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Completion Lymph Node Dissection or Observation for Melanoma Sentinel Lymph Node Metastases: A Decision Analysis
… whether melanoma patients with sentinel lymph node (SLN) metastases should undergo completion lymph node dissection (CLND). Background: Randomized trial results comparing CLND with observation for patients with SLN metastases are not available. Methods: We developed a Markov model to …
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Modern Staging in Primary Breast Cancer-aspects of micrometastatic disease in bone marrow and molecular profiles in lymph node metastases
… not known whether DTCs will grow into overt metastases or which biologic events are involved in the metastatic process. In paper I, Bone marrow biopsies were performed at the time of primary surgery and the presence of DTCs analysed. After 5 years of follow-up, all reports of events were …
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Expression of X-linked Inhibitor of Apoptosis Protein in Neoplastic Thyroid Disorder
… adenomas (8%) was positive for XIAP. Lateral lymph node metastases were more frequent in patients negative for XIAP expression (P=0.01). The BRAFV600E mutation was found in 123 of 164 conventional PTCs (75%). XIAP expression was significantly higher in BRAFV600E mutated PTC than that in wild …
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Statistical aspects of elastic scattering spectroscopy with applications to cancer diagnosis
… the application of ESS to diagnosis of sentinel lymph node metastases in breast cancer, an automated ESS scanner was developed to take measurements from a larger area of tissue to produce ESS images for cancer diagnosis. Problems arise due to the existence of background area in the image with …
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Thyroid hormones and breast cancer-prospective studies on incidence, mortality and prognostic factors
… in breast cancer such as the occurrence of lymph node metastases, and negative oestrogen and progesterone receptor status. It is concluded that thyroid hormone levels are positively related to breast cancer risk and prognosis.
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Optimization and toxocologic effects of cancer immuno-electrogene therapy using a tumor-targeted interleukin-12 gene construct
… dogs had mandibular melanoma with pulmonary and lymph node metastases; one dog had cubital histiocytic sarcoma with spleen metastases; and one had soft palate fibrosarcoma. Treatment of all six dogs was associated with minimal side effects, was easy to perform, was associated with repair of bone …
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Lymphatic pathophysiology of tumors
Lymph node metastases have a negative impact on cancer survival, but the mechanisms for lymphatic metastasis are not well understood. The universal finding in solid tumors of an absence of functional lymphatic vessels seems paradoxical, as cancer cells do travel through lymphatics in order to …
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
Lymphatic vessels play a crucial role in both the pathophysiology of tumors and in the spread cancer cells to lymph nodes. The effects of radiation on these vessels, however, are largely unknown. Here, we seek to describe the effects of ionizing radiation on normal and tumor-associated lymphatic …
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Magnetic Resonance Imaging of a Natural Killer Cell Therapy in a Mouse Model of Prostate Cancer
… Using histology, metastasis was detected in the lymph nodes and spleen of the mice. Necrotic regions in the tumours were detected on day 22 by both anatomical imaging and pyruvate spectroscopy and were confirmed by histology. Conclusions: KHYG-1 cell therapy shows promise as a treatment of …
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Detecting prostate cancer metastases - PET/CT and the sentinel node technique
… highly dependent on the presence or absence of metastases. The available invasive and non-invasive modalities for detecting metastases are imperfect. Positron-emission tomography fused with computed tomography (PET/CT) is a non-invasive method for detecting metastases that is presently evaluated …
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Evaluations and Consequences of Tumour Evolution
… profiles of primary and nodal lesions. Lymph node metastases also lacked uniquely shared subclones, suggesting parallel migration from the primary tumour as the most parsimonious migration path. These findings highlight the possibility of the early acquisition of mutations required for …
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Role of Phosphorylation of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis
… that silencing Yes inhibits prostate cancer lymph node metastasis <em>in vivo</em> in an orthotopic model of prostate cancer tumor growth and metastasis<em>.</em> Furthermore, in human specimens, I demonstrated that Yes expression and phosphorylation of FAK Y861 was increased in lymph node …
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Genetic analysis of squamous cell carcinoma of the head and neck
… genetic relationship between primary HNSCC and lymph node metastases, matched pairs of primary and metastatic tumours were obtained from 18 patients and analysed by CGH. Whilst the overall frequency of genetic alterations was similar between primary and metastatic tumours, a surprising degree of …
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Role of Talin1 Phosphorylation In Beta1 Integrin Activation and Prostate Cancer Metastasis
… is significantly increased in human bone metastases when compared to normal tissues, primary tumors, or lymph node metastases, demonstrating the clinical relevance of talin S425 phosphorylation.</p> <p>In summary, I have identified a novel signaling pathway whereby overexpression of p35 …
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Life Style, Molecular Pathology, and Breast Cancer Risk
… factors, such as tumour size, grade, and lymph node metastases. Co-expression of both estrogen receptors indicated an improved response to endocrine therapy.
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ZNF300 may influence the metastatic properties in pancreatic ductal adenocarcinoma
… formed in the liver. Metastatic cells from the metastases were isolated and grown in culture to yield a lowly metastatic cell line, fast growing (FG). This process was repeated using FG cells, and after three rounds of injection and isolation, the enriched metastatic cells were isolated to yield …
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Diffusion Weighted MR Imaging in the Differentiation between Metastatic and Benign Lymph Nodes in Canine Patients with Head and Neck Disease
In dogs with large primary tumors, regional lymph node involvement or evidence of distant metastasis can have worse prognoses and significantly decreased survival. Lymph node size alone has been shown to be insufficient as a predictor for the accurate clinical staging of some canine neoplasia, …
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Pancreatic Cancer - Early Detection, Prognostic Factors, and Treatment
… from primary pancreatic cancer and matched lymph node metastases. In paper V, pancreatic xenograft tumors were generated in 15 immunodeficient mice by subcutaneous injection of MUC4+ human pancreatic cancer cell lines; Capan-1, HPAF-II, or CD18/HPAF. In paper VI, a 76-member combined …
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Prognostic biomarkers for head and neck squamous carcinoma
… of origin, tumour differentiation, TNM stage, lymph node metastases, overall and disease free survival and treatment outcome were investigated using statistical analysis programme SPSS. Using univariate analysis, ERCC1 expression was significantly associated with poor outcome to treatment. …
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Lymph node metastasis in auricular squamous cell carcinoma
… of the auricle has an unusually high rate of lymph node metastases when compared to similar tumours at other sites. The lymph nodes affected are close to the base of the skull and in the neck. Development of metastasis carries a poor prognosis and most patients will subsequently die of failure …
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