Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 247 for “"lymph node"”.
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Lymph node and peri-lymph node stroma : phenotype and interaction with T-cells
… located inside and surrounding skin-draining lymph nodes play a key role in regulating immune responses. We studied distinct populations of lymph node stromal cells from both human subjects and animal models in order to describe their phenotype and function. In the mouse model, we studied two …
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Completion Lymph Node Dissection or Observation for Melanoma Sentinel Lymph Node Metastases: A Decision Analysis
… whether melanoma patients with sentinel lymph node (SLN) metastases should undergo completion lymph node dissection (CLND). Background: Randomized trial results comparing CLND with observation for patients with SLN metastases are not available. Methods: We developed a Markov model to …
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Lymph node metastasis in auricular squamous cell carcinoma
… of the auricle has an unusually high rate of lymph node metastases when compared to similar tumours at other sites. The lymph nodes affected are close to the base of the skull and in the neck. Development of metastasis carries a poor prognosis and most patients will subsequently die of failure …
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The use of lymphoscintigraphy to localise the sentinel lymph node
Sentinel lymph node (SLN) biopsy is being used increasingly for staging early breast carcinoma in place of complete axillary lymph node dissection. The optimal method to identify the SLN and has not been clearly elucidated in the literature. A number of techniques have been proposed for identifying …
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Sentinel Lymph Node in Rectal Cancer: Role of Transanal Endoscopic Microsurgery
L'abstract è presente nell'allegato / the abstract is in the attachment
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Development of a hydrogel-based microfluidic model of the lymph node
Lymph nodes (LNs) are immunological hubs where antigen and naïve lymphocytes meet to mount antigen specific immune responses. In cancers, the tumour-draining lymph node (TDLN) is the site of initial anti-tumour immune response. The TDLN undergoes dramatic reprogramming in response to tumour …
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Disrupting Tymp-Mediated Pathways to Block Lymph Node Metastasis in Ovarian Cancer
… ovarian cancer, the mechanisms driving lymph node (LN) metastasis are poorly understood, and it remains unclear whether omental metastasis occurs in parallel with LN metastasis. Utilizing comparative transcriptomic and proteomic profiling of primary tumors, LN metastases, and omental …
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Sentinel Lymph Node Biopsy in a Resource Limited Setting: A Retrospective Comparison of Sentinel Lymph Node Biopsy before and after the introduction of SentiMag at an Academic Breast Unit
Background: Sentinel lymph node biopsy (SLNB) is performed for the staging and prognostication of breast cancer in cases with a clinically and radiologically negative axilla. Using blue dye and a radioactive colloid injection is considered the gold standard for SLNB. This study aims to evaluate the …
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T cell Immunomodulation in the Lymph Node for Inhibition of Load-Induced Osteoarthritis
… the crosstalk of joint pathology with local lymph nodes in OA is poorly understood. We characterized the T cell immune response in local lymph nodes following the in vivo mechanical loading of joints. First, we analyzed the change in T cells in lymph nodes following load-induced OA using flow …
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Age-dependent changes in the mouse lymph node and implications for immune responses
… I aimed to investigate different aspects of the lymph node microenvironment to determine whether there are age-related alterations and if so, whether and how these might contribute to the diminished antibody production in aged individuals. The first step of an immune response in the lymph node …
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Evaluation of Different Methods for the Detection of Mycobacterium bovis in Lymph Node Tissue
… for the growth of mycobacteria from bovine lymph node (LN) tissues. A limit of detection study for Mycobacterium bovis, spiked into negative LN tissue, showed that both liquid culture systems supported growth down to a concentration of 2.5 x 102 cfu/ml. A total of 867 routine LN tissues …
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Experience using a small field of view gamma camera for intraoperative sentinel lymph node procedures
… critical in the management of cancer. Sentinel lymph node (SLN) biopsy is one method used in the assessment of cancer spread. SLN procedures are standard practice in the management of some cancers although; these procedures have only recently been developed and refined. SLN procedures are …
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Heterogeneity of Lymph Node Stromal Cells: Bridging the Gap Between Common Practice and New Understandings
Lymph Nodes are some of the most important organs in the body due to their ability to filter lymph and house the adaptive immune response. Without them, lymph would not drain from extremities, causing swelling, and lymphocytes would struggle to find matching receptors for activation. Historically, …
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Analysis of clinical and pathological outcomes of sentinel lymph node biopsy in the SNAC Trial.
Sentinel Lymph Node Biopsy (SLNB) has become the standard procedure to assess the status of the lymphatic drainage in early stages of breast cancer. Currently, SLNB has replaced Complete Axillary Dissection (CAD) when the lymph nodes are clinically negative. The detection of a Sentinel Lymph Node …
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Risk of cervical lymph node metastasis in papillary thyroid carcinoma: Correlations with lymphangiogenesis and ultrasound features
Stratification of risk factors for cervical lymph node metastasis (LNM) in thyroid papillary carcinoma is important for providing standards for post-operative adjuvant radio-iodine therapy and for predicting patient prognosis. We investigated pathological factors based on the lymphatic vessel …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
The lymphatic vasculature is a key player in progression of many cancers, with lymphangiogenesis at the primary tumour and tumour-draining lymph nodes (TDLNs) associated with poor patient prognosis. As well as providing a highway for metastatic tumour cells, recent reports propose lymphatics as …
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Prolonged T – DC macro-clustering within lymph node microenvironments initiates Th2 differentiation in a site-specific manner
… to investigate early Th2 differentiation within lymph nodes (LNs) following cutaneous allergen administration. Contrary to current models, we observed extensive activation and ‘macro-clustering’ of early Th2 cells with migratory type-2 dendritic cells (cDC2s) generating specialized Th2-promoting …
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