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Showing 1 to 6 of 6 for “"lycoricidine"”.
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Total synthesis of lycoricidine via photochemical dearomative dihydroxylation
Lycoricidine a member of the amaryllidaceae isocarbostyril alkaloid family of natural products isolated from bulbs of plants in the amaryllidaceae family, which include the common daffodil. The compound has been demonstrated to possess significant biological activity against a wide range of cancer …
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Studies on the stereo- and regiochemistry of [4+2] cycloaddition of nitroso compounds to chiral halobenzenediols. Total synthesis of lycoricidine
… E 1 and F 2, aminoconduritol A-1 3 and lycoricidine 4. The optical purity of bromocyclohexadienediol, was determined by its conversion to three different natural products ((+)-conduritol E 1, (-)-conduritol F 2, and (+)- aminoconduritol A-1 3), and compared with their optical rotation. …
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Dearomative transformations in synthesis: I. Dearomative dihydroxylation with arenophiles II. Total synthesis of lycoricidine and narciclasine III. Towards the total synthesis of collybolide
… The second chapter describes the synthesis of lycoricidine and narciclasine, two Amaryllidaceae alkaloids with potent anti-cancer activity. Through the application of a Narasaka variant of our dearomative dihydroxylation reaction and a key Suzuki reaction, we have enabled concise access to a …
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Total synthesis enabled by nickel-catalyzed transformations: Dearomative carboamination and methylenecyclopropane annulation
… of the remaining two alkaloids, narciclasine and lycoricidine. The C-7 cupration reaction was used to synthesize a library of analogs previously inaccessible with other reported sequences. The new analogs were found to be equipotent and significantly more soluble in water than the parent natural …
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Controlled synthesis of complex organic molecules and nanomaterials: Engaging chemical properties for biological applications
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Controlled synthesis of complex organic molecules and nanomaterials: Engaging chemical properties for biological applications
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms