Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"lupus nephritis"”.
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Pregnancy and Lupus Nephritis: A Review
The file named "BANSAL-DISSERTATION-2017.pdf" is the primary dissertation file. A supplemental PDF file ("Appendix - Data.pdf") is also available and may be viewed individually.
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… defining feature of autoimmune diseases, such as lupus nephritis (LN), in which persistent immune activation leads to progressive kidney injury and fibrosis. Macrophages play a central role in this process because of their functional plasticity and ability to respond to environmental cues. …
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Isoform-Selective HDAC Inhibition for the Treatment of Lupus Nephritis
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease requiring a genetic predisposition coupled with an environmental trigger in order for initiation of disease. While the exact pathoaetiology has yet to be determined, both B and T cell dysregulation are thought to contribute to …
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Outcomes of renal transplantation in patients with lupus nephritis: a single centre study in Cape Town
Background: Kidney disease (lupus nephritis [LN]) constitutes a feature of systemic lupus erythematosus (SLE) in up to 50 - 70% of patients with the disease. Although most LN patients are suitable for renal transplantation when they develop end stage renal disease (ESRD), the risk of recurrence of …
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Retrospective comparison of cyclophosphamide and mycophenolate mofetil in lupus nephritis at Groote Schuur Hospital nephrology unit
Background. Lupus nephritis (LN) can be complicated with requirement for kidney replacement therapy and death. Efficacy of induction therapies using mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVCYC) has been reported from studies, but there is limited data in Africans comparing …
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Clinico-pathological features of repeat renal biopsies in patients with lupus nephritis at Groote Schuur Hospital, Cape Town
… Repeat renal biopsies in patients with lupus nephritis (LN) are usually done to guide treatment or to establish disease chronicity. Their value is not clear from available literature. There is also no available data in Africa to guide clinicians. Methods: This was a retrospective study …
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Using urinary MCP-1 and TWEAK to assess disease activity in a cohort of South African patients with lupus nephritis
… Renal involvement is common in systemic lupus erythematosus (SLE) and can lead to chronic kidney disease (CKD). Diagnosis of lupus nephritis (LN) is dependent on renal biopsy. Due to its invasiveness, repeat renal biopsy for monitoring disease activity is not recommended, thus creating a …
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Correlation of urinary mcp-1 and tweak with renal histology and early response to therapy in newly biopsied patients with lupus nephritis in cape town, South Africa
… use of immunosuppression in patients with active lupus nephritis (LN), however this is guided by renal biopsy which is invasive and not freely available in most centres. Novel urinary biomarkers such as monocyte chemoattractant protein-1 (MCP-1) and tumour necrosis factor-like weak inducer of …
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The Dendritic Cell Response to Exogenous and Endogenous Danger Signals
Systemic lupus erythematosus (SLE) is complex autoimmune disease in which autoantibodies form against double stranded DNA (dsDNA) and nuclear antigens. Autoantigen immune complexes form, deposit in the vasculature, and cause multisystem organ damage. Both genetic and environmental factors …
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Mechanistic Insights on The Immunomodulatory Functions of Diverse Environmental Factors on Systemic Autoimmunity
… systemic immune dysregulation, taking systemic lupus erythematosus (SLE or Lupus) as a model of systemic autoimmunity. SLE is one of the most mysterious autoimmune disorders with no known cure. In SLE, breaching of tolerance to self-antigens and the subsequent persistent inflammation and …
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NOVEL SYNTHETIC PROCESSES FOR THE INDUSTRIAL PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS
… the immunosuppressant medication treatment of Lupus nephritis. A four synthetic steps process was developed to afford the product with the required purity and isomeric composition.
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The modulation of autoimmune disease progression in mouse models
… diseases, type 1 diabetes (T1D) and systemic lupus erythematosus (SLE). In the past decade, numerous studies showed positive responses of B cell depletion therapies in these two diseases. However, the beneficial effects are temporary and accompanied with adverse events. In this dissertation, …
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Pathological role of double-stranded DNA antibodies in multiple sclerosis.
… and in view of their known pathogenity in lupus nephritis the aim of this project was to further investigate their role in multiple sclerosis. Using the acute experimental allergic encephalomyelitis (EAE) model in the Lewis rat, the inflammatory phase of disease was profiled using …
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The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic multifactorial inflammatory autoimmune disease with heterogeneous clinical manifestations. Among different manifestations, lupus nephritis (LN) remains a major cause of morbidity and mortality. There are few FDA approved treatments for LN. In general, …
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Screening and Functional Analysis of New Anti-Complement Autoantibodies in the Course of Systemic Lupus Erythematosus // Скрининг и функционален анализ на нови анти-комплементни автоантитела в хода на системен лупус еритематодес
… about the aetiology and pathogenesis of systemic lupus erythematosus (SLE). The disease is characterized by broad-spectrum organ manifestations, multiple autoantibodies and multifactorial immunological pathogenesis. Lupus nephropathy is one of the most severe, significant and common manifestations …
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Haplotype-Specific Effects of the Slam/Cd2 Family on the Immune Response
… antigens in the NZM2410 model of systemic lupus erythematosus (SLE). Congenic B6 mice carrying the Sle1b locus produce anti-nuclear autoantibodies (ANAs) but do not develop lupus nephritis as seen in the parental NZM2410 strain. Fine mapping of the Sle1b locus placed it within a 900kb …
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Significance of leptin and ghrelin in systemic lupus erythematosus in Koreans
… have been described in patients with systemic lupus erythematosus (SLE), however there were no information about serum leptin and ghrelin level, antagonist hormone of leptin, in patients with SLE. We have evaluated the differences of serum leptin and ghrelin levels between patients with SLE and …
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Beta2-microglobulin and antichromatin antibodies can be a disease activity markers in Systemic Lupus Erythematosus in Koreans
… have been described in patients with systemic lupus erythematosus (SLE) and it has been suggested that their presence is associated with lupus disease activity. We have investigated the clinical significance of beta2-microglobulin and antichromatin antibodies in Korean SLE patients. MATERIALS …
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The role of gut microbiota in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with no known cure. Despite years of study, the etiology of SLE is still unclear. Both genetic and environmental factors have been implicated in the disease mechanisms. Gut microbiota as an environmental factor and the immune …
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Investigations into the role of exogenous estrogenic endocrine disrupting chemicals on immune dysregulation in autoimmune disease
… this EEDC. Autoimmune diseases, such as systemic lupus erythematosus (SLE), are characterized by a dysregulated immune system that has lost tolerance to self-antigens. The pathogenesis of SLE is still poorly understood. However, it is likely that genetics, epigenetics, hormones, and environmental …
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