Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"lung tumours"”.
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Gain-of-function and dominant-negative effects of distinct p53 mutations in lung tumours
Lung cancer is the most common cause of cancer-related mortality worldwide with current treatments providing limited therapeutic benefit in most cases. TP53 (Trp53, p53) mutations occur in approximately 50% of lung adenocarcinoma cases and are associated with poor prognosis and so novel therapies …
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Examination of gene deletion as a mechanism of RBM5 downregulation in tobacco smoke-associated lung cancer
… with substantially decreased expression in most lung cancers, especially in smokers, that may result from gene deletion. The objective of this study was to determine if significantly decreased levels of RBM5 expression in the lung cancers of smokers was related to RBM5 deletion. Using DNA from …
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Development of a Dry Powder Inhaler and Nebulised Nanoparticle-Based Formulations of Curcuminoids for the Potential Treatment of Lung Cancer. Development of Drug Delivery Formulations of Curcuminoids to the Lungs using Air Jet Milling and Sonocrystallisation Techniques for Dry Powder Inhaler Preparations; and Nanoemulsion and Microsuspension for Nebuliser Formulations
… The highest rate of cancer deaths comes from lung tumours; therefore, inhaled curcuminoids could treat lung cancer locally. To date, there are no nebulised formulations of curcuminoids, and there are no inhalable curcuminoids particles without excipients using air jet mill and …
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Development of a Breathing Monitor and Training System, And the Analysis of Methods of Training Patients to Regulate their Breathing when Undergoing Radiotherapy for Lung cancer
… radiotherapy treatments for Non-Small-Cell Lung Cancer (NSCLC) rely on conforming the radiation dose to the tumour geometry as tightly as possible; this increases the probability of killing the tumour cells while simultaneously reducing the radiation dose to nearby tissues and to organs at …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
Lung cancer is one of the main causes of death worldwide, with most patients suffering from an advanced unresectable or metastatic non-small cell lung cancer. The mortality trends are mostly related to patterns of tobacco use, specifically from cigarettes. Tobacco is the basic etiological agent …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
Lung cancer is one of the main causes of death worldwide, with most patients suffering from an advanced unresectable or metastatic non-small cell lung cancer. The mortality trends are mostly related to patterns of tobacco use, specifically from cigarettes. Tobacco is the basic etiological agent …
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Role of Monocarboxylate transporter in lung development and lung cancer
Some studies suggest that lung tumour cell ontogeny is determined by consequences of gene expression that recapitulate important events in embryonic lung development. Hypoxia plays a crucial role either in physiological or pathological conditions such in tumour growth, and in embryonic and fetal …
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The role of proteases in development of cancer in mice
… useful models for cancer because they develop tumours spontaneously after treatment with ethylcarbamate. The first study was to investigate the changes in protease activity in tumour bearing and in normal tissues such as lung, liver and skelatal muscle. Using a modified fluorescent assay, …