Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"lung transplant"”.
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Missing Domains Of Lung Transplant Patient Selection
… scientific community in the thirty years since lung transplantation became the procedure of choice for patients with terminal, non-malignant lung disease. Background: Though there is a consensus regarding disease-specific indications for a lung transplant, ambiguity remains regarding how …
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Bone Health Outcomes in Post-Lung Transplant Patients with Cystic Fibrosis
… in patients with cystic fibrosis (CF). Although lung transplantation (LTx) improves quality of life of CF patients, there is little research examining long-term bone health outcomes following LTx in these patients. OBJECTIVE: We sought to compare long-term bone health outcomes in LTx patients …
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
Abstract Long-term outcomes for lung transplantation remain disappointing; as many as 50% of lung transplant recipients develop progressive Bronchiolitis Obliterans Syndrome (BOS) by 5 years after transplant. In the last decade, several experimental and clinical studies have demonstrated that …
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Cytomegalovirus Infection in Heart and Lung Transplant Patients with focus on long-term outcome
… a common opportunistic infection after heart and lung transplantation. The aims of this thesis were to relate the incidence and severity of CMV infection and disease to different forms of antiviral prevention and to evaluate whether CMV is a risk factor for bronchiolitis obliterans syndrome (BOS) …
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Pulmonary Artery and Central Venous Pressures as Prognostic Indicators of Post Lung Transplant Outcome
… (CVP) on poor prognosis in patients undergoing lung transplants has been widely debated. We hypothesized that not only the isolated values of mPAP and CVP, but also the combination of discordant values in these variables may represent an unfavorable condition in lung transplantation. Methods We …
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Skeletal muscle mitochondrial capacity and metabolism in lung transplant patients and resistance trained subjects
Lung transplant (LTx) recipients have poor exercise tolerance, which persists in spite of the restoration of near normal lung function. This suggests that the exercise limitation is related to defects in skeletal muscle. Firstly, mitochondrial function and metabolism in resting skeletal muscle were …
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Fighting time: A qualitative analysis on the impact of lung transplantation in adults with Cystic Fibrosis
During the last decade lung transplantation has become an option for those with end-stage respiratory disease, including Cystic Fibrosis. However, there appears to have been very little written about the experiences of those who are on the lung transplant trajectory. Most of the previous …
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Exhaled breath analysis using laser absorption spectroscopy
… was evaluated as a marker of acute rejection in lung transplant recipients. A continuous wave thermoelectrically cooled quantum cascade laser at 5.47 microns coupled with off-axis integrated cavity output spectroscopy (ICOS) was developed to simultaneously measure exhaled NO and CO2. Using the …
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Invasive fungal disease in immunocompromised hosts with focus on diagnostics
… Paper IV was a prospective nationwide study on lung transplant recipients where serum and BAL-fluid samples were collected during the first post-transplant year for the analysis of betaglucan. Development of bronchiolitis obliterans syndrome (BOS) was assessed during a median 4.6 years of …
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Precision Diagnostics of Donor Lungs Ex Vivo
Ex vivo lung perfusion (EVLP) is an advanced technology that reconditions donor lungs prior to transplantation. Lung monitoring during EVLP provides isolated lung data without confounding factors from other physiological systems. Herein, we used machine learning modelling to process EVLP diagnostic …
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Selection Bias In Lung Allocation: Influence On Lung Allocation Score And Physician Decision-Making
In the U.S., donor lungs are allocated to recipients based on a lung allocation score (LAS). While the statistical models used to construct the LAS control for patients’ demographic and clinical values, they do not account for selection bias, which arises because: (1) individuals are removed from …
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Identification and Analysis of Omentum Derived Suppressor Cells in Regards to Th17 Inhibition
… as a cellular therapy in a mouse allogenic lung transplantation model.</p> <p>Our findings demonstrated activated omentum is mostly comprised of non-hematopoietic cells resembling mesenchymal stem-like cells (MSCs) and myeloid derived suppressor cells (MDSCs). Activated omentum exhibited …
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Examination of ex-vivo lung perfusion in porcine model
Lung transplantation is a lifesaving therapeutic option for a variety of endstage cardiopulmonary conditions. There is a critical mismatch between the availability of suitable lungs and the number of patients awaiting a lung transplant. Ex-vivo lung perfusion (EVLP) is an established technique that …
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The gift of life: an existential phenomenological exploration of receiving a lifesaving organ transplant and how this affects life subsequently
… there is little research conducted on organ transplantation from the perspective of the organ recipient. This study aimed to explore the experience of undergoing lifesaving organ transplantation and how this may affect life subsequently. For the purpose of this research, lifesaving …