Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"lung metastases"”.
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Targeting Pd-1/Pdl-1 Signaling In The Treatment of Osteosarcoma Lung Metastasis
… was to determine if PD-1 blockade leads to of OS lung metastasis regression and study the role of NK cells and/or macrophages in the anti-PD-1 responses. We demonstrated that PDL-1 is expressed in human OS cell lines and in lung metastases from OS patients, implying that its importance as a …
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ELUCIDATING THE FUNCTIONS OF TAp73 IN BREAST CANCER
… overall survivability, and had developed fewer lung metastases as compared to its littermate control. In contrast, the PyMT mice with TAp73 knockout specifically in the cancer-associated fibroblasts or the tumor-associated macrophages developed more lung metastases as compared to the control …
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Romidepsin is a Potential Therapeutic to Treat Metastatic Osteosarcoma
… adolescents, and dogs. Lethality is due to lung metastases. Despite standard of care, patients with lung metastases have a survival rate of only 25%. Therefore, our lab studied potential therapeutics to target lung metastases. To do this, our lab repurposed already FDA-approved oncology …
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The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip
… death. OS metastasizes almost exclusively to the lungs. We have shown that Fas expression in OS cells is inversely correlated with their metastatic potential. Fas<sup>+</sup> cells are rapidly eliminated when they enter the lungs via interaction with FasL, which is constitutively expressed in the …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… clonal and transcriptional dynamics across PT, lung metastases, and CTCs. I further developed a high‐throughput workflow to isolate large numbers of viable CTCs from metastasis‐bearing mice, enabling matched multi‐compartment analyses. Targeted metabolomics and Seahorse assays profiled metabolic …
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Design and development of an RNA vaccine against tumor-mediated angiogenesis and metastasis targeting a KLH-Adrenomedullin fusion protein
… were injected through the tail vein to induce lung metastases. In addition, transgenic mice expressing green fluorescent protein in the blood vessels (SMAA-GFP) were also immunized with both LNP types to assess the effect of the vaccine in subcutaneous tumors and potential side-effects of the …
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Combination Therapy With Aerosol Il-2 and Nk Cells For The Treatment of Osteosarcoma Lung Metastasis
<p>The survival of patients with osteosarcoma lung metastases has not improved in the last 20 years. Novel alternative therapies are needed. The purpose of this investigation was to evaluate the efficacy of combining natural killer [NK] cell therapy with aerosol interleukin-2 [IL-2] for the …
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Development of an oral DNA anti-cancer vaccine targeting an angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
… injected either into the tail vein to generate lung metastases or subcutaneously to generate cutaneous melanoma. Furthermore, naive CD4+ T cells were exposed to PAMP, and their secretome was analyzed by proximity extension assays. Results: In the lung metastasis model, a humoral and cellular …
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Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… analysis of clinical samples that melanoma brain metastases (MBMs) have higher expression of oxidative phosphorylation (OXPHOS) genes (including <em>PPARGC1A</em> or <em>PGC1α</em>) than patient-matched extracranial metastases (ECMs). <strong>Thus, the central hypothesis of this dissertation is …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
… and the second in American women (after lung cancer) according to CDC. In the most advanced stage of BC, stage IV, cancer cells metastasize from the original site to distant organs, such as bone, lung and liver. Tumor metastasis is responsible for nearly all of the morbidity and mortality …
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PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
… to enhance glycolysis and OXPHOS, promoting lung metastases by inhibiting GSK-3 activity. Prune1's mitochondrial localization and interaction with ATP5A1 highlight its role in OXPHOS-mediated ATP production. The Prune1 inhibitor (LEO-AA7.5(S)T) was shown to impair tumor metastasis, enhance …
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Reprogramming the Tumor Microenvironment in Desmoplastic Tumors to Potentiate Cancer Immunotherapy
… kidney, bladder, head and neck, renal, and lung cancers. However, similar outcomes have yet to be achieved in metastatic breast cancer (mBC). This is likely in part due to the presence of an immunosuppressive tumor microenvironment (TME), driven by a highly desmoplastic stroma in mBC. For my …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… deaths is tumour metastasis. The formation of metastases is a complex multistep process, involving invasion of the basal membranes and connective tissue, penetration of the blood vessel walls, invasion of the host tissue, and initiation of growth at the new location. The degradation of …
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
<p>Lung cancers are leading cause of cancer death for both men and women in the world. Lungs are also one of the primary organs to which almost all cancer can spread. Chemothepray plays a crucial role in the fight against both primary lung cancers and lung metastases. Doxorubicin (DOX) is a potent …
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Characterization of Erbb4 Expression In Osteosarcoma
… localized to the nucleus in primary tumors and metastases in studies characterizing ERBB4 expression in osteosarcoma, indicating that ERBB4 may be cleaved to enhance malignant behavior in osteosarcoma. ERBB4 protein was significantly up-regulated from monolayer to sphere cultures in …
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The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer
… tumor incidence and weight, and decreasing gross lung metastases while not increasing uterine weight. A pre-tumor study was conducted to gain insight into these protective effects. Randomized, non-ovariectomized, 60-day old female MMTV/unactivated Neu mice were provided therapies comprised of E2 …
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Targeting the adenosine pathway reshapes a myeloid-dependent tumour microenvironment in pancreatic ductal adenocarcinoma. An opportunity for therapeutic intervention
… tumour growth and reduced the occurrence of lung metastases in IOT-resistant tumours. Further, Adoi improved the efficacy of combinations of cytotoxic agents or immunotherapy. Genes related to immune modulation, hypoxia response and tumour stroma were downregulated following Adoi. Further …
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Simvastatin Does Not Sensitize Ibc3 Her2+ Inflammatory Breast Cancer Brain Metastases to Whole Brain Irradiation In An Immunocompromised Mouse Model
… IBC cells in vitro [23], and brain metastases have strong expression of cholesterol-regulation genes compared to lung metastases <em>in vivo</em> [unpublished]. Delaying whole-brain irradiation (WBI) beyond 21 days is insufficient to reduce the incidence of brain metastases …
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Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
… in ~30% of primary breast tumors and ~70% of metastases, which independently correlates with poor prognosis and decreased survival in patients. A precise role for HIF-2 in breast cancer is still being elucidated.</p> <p>Our lab has established primary mammary tumor epithelial cells (MTECs) …
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A New Mathematical Theory for the Dynamics of Large Tumor Populations, a Potential Mechanism for Cancer Dormancy & Recurrence and Experimental Observation of Melanoma Progression in Zebrafish
… different species, including CT scans of mouse lungs to infer lung metastases sizes. Ultimately, the model may offer a flexible way to predict the progression of the cancer by using noninvasive imaging data to find model parameters.</p>
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