Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"lung inflammation"”.
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Characterization of Lung Inflammation Induced by Exposure to Fipronil
… potential impact of exposure to fipronil on the lungs. We studied the same by exposing mice to fipronil intranasally (N=8) or orally (N=7) for 7 days followed by collection of blood, broncho-alveolar lavage (BAL) fluid and lung tissues. Control mice were given corn oil (N=15). The oral and …
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Cathepsin S as a mediator of acute lung inflammation
… can become dysregulated and cause damage to the lung, contributing to the pathology of conditions like cystic fibrosis, chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and ARDS. Increased protease activity is thought to be caused, at least in part, by the loss of endogenous …
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Aging Effects on Acute Lung Inflammation After Burn Injury
… they are at an even greater risk of pulmonary inflammation than young mice given a comparable sized wound. We found that neutrophils continue to accumulate in the lungs of aged mice at 24 hours after burn injury, but do not migrate into the alveoli. We also showed that neutrophil migration …
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YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION
… plays a pivotal role in protecting the lungs from inhaled infectious agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery from these insults to rebuild the epithelial barrier and restore pulmonary functions. Here, we show that sublethal …
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Characterizing Lung Inflammation in Agricultural Respiratory Exposures Between the Sexes
… male response; and 3) observing the structural lung changes of the combined exposure to glyphosate and LPS in female mice as measured using multiple image radiography. Female mice, exposed to LPS and glyphosate for 5 days showed higher levels of inflammatory mediators compared to control …
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An investigation into the role of Pellino2 in lung inflammation
… mice were subjected to experimental models of lung injury. The studies suggest an important role for Pellino2 in mediating the early inflammatory response in elastase-induced emphysema. Interestingly whilst early inflammation was suppressed in Pellino2-deficient mice, these mice demonstrated …
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Role of scavenger receptor MARCO in particle uptake and lung inflammation
… form the first line of defense against chronic inflammation caused by occupational exposure to environmental particulates such as crystalline silica (CSiO2). The chronic inflammatory process triggered by CSiO2 is known to culminate into a fibrotic response called silicosis in the human lungs. …
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Role of scavenger receptor MARCO in particle uptake and lung inflammation
… form the first line of defense against chronic inflammation caused by occupational exposure to environmental particulates such as crystalline silica (CSiO2). The chronic inflammatory process triggered by CSiO2 is known to culminate into a fibrotic response called silicosis in the human lungs. …
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Biomarkers and cell phenotypes in TB patients with minimal or persisting lung inflammation post-anti-TB treatment and ex-vivo atorvastatin immunomodulatory effects on M. tuberculosis-infected PBMC
Unresolved lung inflammation post-anti-TB treatment necessitates the evaluation of additional host-directed therapies (HDT). Statins, recognized for their pleiotropic effects, show potential as immunomodulators to reduce post-TB lung inflammation. The ongoing StatinTB clinical trial utilizes a …
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THE EXPLORATION OF THE VALIDITY OF QUANTITATIVE 2-DEOXY-2-[FLUORINE-18] FLUORO-D-GLUCOSE (18F-FDG) POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY (PET/CT) TO ASSESS LUNG INFLAMMATION
Lung diseases are one of the leading causes of death in the UK; responsible for 20% of all deaths each year. Inflammation is thought to be an important driver of the pathogenesis and progression of several lung diseases. Positron emission tomography/computed tomography (PET/CT) is an imaging …
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Development Of New Therapy to Combat Tuberculosis Induced Inflammation
… response, which can lead to irreversible lung damage, even after successful antibiotic therapy. This thesis investigated the effectiveness of two anti-inflammatory agents, Tristetraprolin (TTP) and FhHDM-1, to reduce lung inflammation during TB infection. A mouse model expressing active …
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Ketogenic Diet is Protective During Endotoxin-Induced Lung Injury
… respiratory distress syndrome (ARDS) is a lung condition caused by uncontrolled lung inflammation with excessive immune cell infiltration, which eventually leads to severe pulmonary edema and poor oxygenation. ARDS affects hundreds of thousands of people a year, particularly those afflicted …
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The role of IL-4Ra during acute schistosomiasis
… for the extent pf schistosome egg induced lung inflammation and pathology.
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From Flare to Repair: Commensal Bacteria's Influence on Inflammation and Wound Healing
… remains unclear how bacterial dysbiosis drives inflammation beyond the gut, how the microbiota influences the central nervous system (CNS) where microbes are absent, and if there are specific commensals that may attenuate inflammation. To that end, Chapter 3 demonstrates that IL-10 deficiency …
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RESPIRABLE SIRNA TARGETING AT THE NF-KB PATHWAY PROTECTS AGAINST INFLAMMATORY LUNG DISEASES
… and Rip2 levels in mouse cell lines and mouse lung. RPS3 siRNA abated HDM-induced mucus hypersecretion, cytokine production, and serum IgE elevation. RPS3 and Rip2 siRNA ameliorated neutrophil infiltration and suppressed CS-induced inflammatory and oxidative damage marker levels. Here we …
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Implicación de igf1r en inflamación pulmonar aguda y en alergia inducida por ácaros del polvo doméstico en ratones
… IGFs were reported to play a role in chronic lung pathologies including cancer, ARDS, COPD, pulmonary fibrosis and asthma, in which inflammation is a relevant component. Methods: Igf1r deficiency was induced in four-week-old UBC-CreERT2; Igf1rfl/fl mice by five consecutive intraperitoneal …
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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature
<p>Acute lung inflammation (ALI), stemming from a disproportionate and detrimental immune response, may arise from or complicate other disease states, leading to the often-fatal acute respiratory distress syndrome (ARDS). Because of the many culpable factors and differing points of induction, …
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Exhaled breath analysis using laser absorption spectroscopy
… was evaluated as a marker of acute rejection in lung transplant recipients. A continuous wave thermoelectrically cooled quantum cascade laser at 5.47 microns coupled with off-axis integrated cavity output spectroscopy (ICOS) was developed to simultaneously measure exhaled NO and CO2. Using the …
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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… effects of CB2 agonists on allergic airway inflammation using a mouse model of asthma and resolve any mechanisms that underpin the immunosuppressive properties observed using in vitro assays. The murine model of allergic lung inflammation entailed transferring ovalbumin (OVA) specific CD4+ T …
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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… effects of CB2 agonists on allergic airway inflammation using a mouse model of asthma and resolve any mechanisms that underpin the immunosuppressive properties observed using in vitro assays. The murine model of allergic lung inflammation entailed transferring ovalbumin (OVA) specific CD4+ T …
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