Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"lung infection"”.
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THE ROLE OF T-BET IN LUNG INFECTION
… type 1 inflammatory responses against a range of infections. In this thesis, a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection was demonstrated. T-bet deficiency did not adversely affect the efficacy of viral clearance or recovery compared to wild-type hosts. …
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A guinea pig model of human respiratory syncytial virus lung infection
… Because latent or persistent pulmonary viral infections have been implicated in the pathogenesis of the airway inflammation underlying asthma, a guinea pig model of human RSV lung infection was developed to test the hypothesis that RSV persists within the lung following resolution of acute …
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Development of an inhaled liposomal-loaded azithromycin formulation for the treatment of chronic respiratory infection
Chronic lung conditions such as cystic fibrosis and bronchiectasis are characterised by cycles of inflammation and infection. Long term antibiotics are commonly prescribed in these conditions to decrease exacerbation frequency and improve quality of life. Azithromycin is often given orally for this …
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Antimicrobial and immuno-modulatory peptides as a treatment for lung disease and delivery by nebulisation
Respiratory infections are of significant concern for individuals with chronic inflammatory lung diseases and there is an unmet need for novel antibiotics. Antimicrobial peptides possess antibiotic potential due to their antimicrobial and/or immunomodulatory properties. The project aim was to …
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Elucidating Pseudomonas aeruginosa virulence gene regulation by the ribbon-helix-helix transcription factor AmrZ
… aeruginosa </italic> causes a myriad of infections to immunosuppressed patients, including endocarditis, microbial keratitis of the eye, pneumonia, urinary tract infections, and chronic lung infection in patients with cystic fibrosis. The underlying cause of the severity of these …
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Allergen Sensitization and Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model
… to confer resistance against bacterial and viral lung infection. These findings, combined with studies performed using CpG ODNs, led to speculation that PUL-042 dampens the immune response in allergen-induced asthma. My thesis research investigated airway route sensitization and airway delivery of …
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Tackling Mycobacterium abscessus infection in Cystic Fibrosis
… abscessus is an emerging pathogen with infections increasing worldwide, especially among Cystic Fibrosis (CF) patients. During my PhD, I studied key aspects of the biology of M. abscessus spp.; particularly, I studied host-pathogen interactions, antimicrobial resistance mechanisms, and …
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Nucleic acid modifications in bacterial pathogens - impact on pathogenesis, diagnosis, and therapy
… enormous global disease burden due to bacterial infections, and the rapidly increasing rates of antibiotic resistance reported across the world, the need for research to address mechanisms of bacterial survival is more pressing than ever. The goal of this thesis was to determine the function of …
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A comparative and phylogenetic analysis of the genome of Pseudomonas aeruginosa
… for approximately 10% of hospital acquired infections (Davies, 2002). In particular, this free living, extremely virulent pathogen is a worry to clinicians involved in the care of patients suffering from cystic fibrosis, the genetically acquired, multi-system disease. Within the CF lung, P. …
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Assessment of an ex vivo porcine lung model to investigate host-microbe interactions in cases of ventilator associated pneumonia
VAP is described as a pneumonic lung infection afflicting those that have been mechanically ventilated typically with an endotracheal tube. Unfortunately, there is no singular diagnostic test for VAP (Grossman & Fein, 2000) or ‘gold standard’ for the identification and diagnosis of the disease …
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Identifying cross-species regimens for the treatment of rapid-growing and slow-growing nontuberculous Mycobacterium pulmonary infections
… concentration (MIC) testing, Raw264.7 macrophage infection assays, and preclinical NTM lung infection models (C57BL/6 for M. avium and NOD.CB17-Prkdcscid/NCrCr for M. abscessus). Efficacy was directly measured as the reduction in lung bacterial count (Δlog10 CFU) compared to untreated controls. …
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Investigation and application of heterochiral proteins enabled by flow-based peptide synthesis
… (ADCs) for the treatment of P. aeruginosa infection. New therapeutic modalities are needed to address bacterial resistance to conventional antibiotics. We developed a biologically expressed antibody that targets P. aeruginosa and bears antimicrobial peptides chemically synthesized from …
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Pseudomonas aeruginosa Type IV pilus and resistance to the antimicrobial properties of surfactant protein-A
The lung contains numerous innate immune cells and effector proteins. One important component of this immune system is the surfactant protein-A (SP-A), which facilitates microbial clearance by opsonization and membrane permeabilization. Pseudomonas aeruginosa (PA) is a major Gram-negative bacterial …
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A novel cough aerosol sampling device for sputum-scarce individuals with tuberculosis
… worldwide, with 1.6 million deaths. Bacterial infection occurs when aerosol droplets enter the respiratory tract and travel to the lungs, causing pulmonary disease. If untreated, the disease has a 50% mortality rate. TB diagnostics require a sputum sample to conduct tests to confirm the …
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Cellular innate immune responses to lung resection via video- assisted thoracoscopic surgery (VATS) and thoracotomy : predictors of post-operative pneumonia
… of post-operative pneumonia following lung resection is poorly understood despite it being the most common complication which may lead to death. The role of the acute inflammatory response following lung resection, in particular innate immune cells, was investigated and used to identify …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… of immunity in cancer, transplantation, infection and autoimmunity. The studies presented in this thesis investigate two novel gene mutations that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… of immunity in cancer, transplantation, infection and autoimmunity. The studies presented in this thesis investigate two novel gene mutations that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening …
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Developing novel therapies for Mycobacterium abscessus
… exacerbations and an accelerated decline in lung function. Current treatment outcomes are extremely poor. There is therefore an urgent need to understand how M. abscessus resists killing by existing antibiotics and to find new treatments. I have attempted to address these issues in this …
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Adhesive and signaling mechanisms in abdominal sepsis
… units despite decades of scientific efforts. The lung is recognized as the most sensitive and critical organ affected by the hyper-inflammatory response in septic patients. Immune cell dysfunction develops in later phases of sepsis making patients susceptible to infections. The aim of this …