Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"lung fibrosis"”.
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A Predictive Model for Lung Fibrosis after Irradiation
… AND METHODS 3 A. PATIENT ELIGIBILITY 3 B. FIBROSIS MEASUREMENT/3-D TREATMENT PLANNING 5 C. STATISTICAL ANALYSIS 7 Ⅲ. RESULTS 8 A. DVH AND FIBROSIS VOLUME 8 B. MLD AND FIBROSIS VOLUME 8 C. PATIENT FACTORS ASSOCIATED WITH FIBROSIS VOLUME 11 D. FIBROSIS VOLUME AND REDUCTION OF PULMONARY …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
<p>Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects about 5 to 8 million individuals in the world. Despite the high prevalence, there is currently no cure for IPF, and the cause of this disease is still unclear. Our laboratory and collaborators have shown that nudix …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… (COPD) is an irreversible disease reducing lung function via processes of inflammation, emphysema and fibrosis. Patient treatment options are limited including bronchodilators and inhaled corticosteroids that are poorly effective. Linked with a significant history of cigarette smoking, …
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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases
… cells. HP is a hypersensitivity disease in the lung which may result in chronic lung fibrosis with high mortality. Corticosteroids such as prednisolone may help to control acute HP symptoms but may also produce side effects and not be effective to all patients. Because under the same …
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
<p>Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects 5 - 8 million individuals worldwide and 200,000 individuals in the United States alone. Although prevalent, we do not know what causes IPF and no effective curative treatment exists for this disease. Our laboratory has …
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The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
… their potential benefits in treating pulmonary fibrosis. This was achieved through a series of in vitro studies and an in vivo model of lung disease, namely, bleomycin induced pulmonary fibrosis. Firstly MSC expansion of Treg cells was shown to be dependent on Jagged 1 signalling. MSC inhibition …
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PERINATAL CELLS AS A TREATMENT FOR INFLAMMATORY LUNG DISEASES
… with many pulmonary conditions such as Cystic Fibrosis (CF), chronic obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome (ARDS). Often, patients with inflammatory lung disease exhibit increased immune cell counts in their lungs such as neutrophils, macrophages …
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LUNG CLEARANCE INDEX: a new biomarker of ventilation inhomogeneity in pediatric respiratory diseases.
… is not sensitive for the early detection of lung damage affecting the small airways or the evaluation of homogeneity of air ventilation. For these reasons, techniques such as gas dilutions and multiple-breath washout (MBW) have been implemented over the last few years because they allow for …
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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis
<p>Pulmonary fibrosis involves the invasion of lung tissue with fibrotic, scar tissue and affects roughly five million people total worldwide. Fibrotic development in the lung has several causes, including chronic inflammatory diseases, infections, medical compounds, and environmental agents. There …
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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis
<p>Pulmonary fibrosis involves the invasion of lung tissue with fibrotic, scar tissue and affects roughly five million people total worldwide. Fibrotic development in the lung has several causes, including chronic inflammatory diseases, infections, medical compounds, and environmental agents. There …
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An investigation into the role of Pellino2 in lung inflammation
… mice were subjected to experimental models of lung injury. The studies suggest an important role for Pellino2 in mediating the early inflammatory response in elastase-induced emphysema. Interestingly whilst early inflammation was suppressed in Pellino2-deficient mice, these mice demonstrated …
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Soy Isoflavones Mediate Radioprotection Of Normal Lung Tissue By Modulating The Radiation-Induced Inflammatory Response
<p>Radiation-induced lung injury (RILI) is caused by an early inflammatory process triggered by damage to lung parenchyma, epithelial cells, vascular endothelial cells and stroma. Initially, oxidative injuries after radiation induce altered expression of pro-inflammatory cytokines. Infiltrating …
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CHARACTERIZATION AND EVALUATION OF CLINICALLY RELEVANT READOUTS IN A PRE-CLINICAL MODEL OF IDIOPATHIC PULMONARY FIBROSIS (IPF)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive age-related interstitial lung disease (ILD) with a poor prognosis and very limited therapeutic options (Raghu et al. 2015; Spagnolo et al. 2018). To date, Pirfenidone and Nintedanib are the only two therapies approved for IPF worldwide. …
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Organ Specific Vascular Response to Fibrosis Affects Breast Cancer Metastatic Organotropism
… and basic science research has shown that fibrosis presents an environment that favors tumor growth, such as hepatocellular carcinoma being commonly preceded by liver cirrhosis, or bleomycin induced lung fibrosis enhancing pulmonary metastasis in mouse models of breast cancer. In addition …
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Systemic sclerosis. Novel molecular and epidemiological features of disease.
… presented from various parts of the world. While lung involvement is a common cause of SSc-related death, a majority of SSc patients suffer from symptoms originating in the gastrointestinal (GI) tract. By combining data from a population based register with individual case ascertainment, we …
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VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… In pathological situations like pulmonary fibrosis, the change of ECM can affect the endothelium permeability in response to mechanical perturbations. In this chapter, I showed that ECM proteins and the substrate rigidity coordinate to modulate force activated signaling cascades. Findings …
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Proliferation von Lungenfibroblasten in vitro unter dem Einfluss von ionisierender Strahlung bzw. von TGF-Beta 1
Die Lunge wird häufig im Rahmen der Behandlung maligner Tumoren im Thorax bestrahlt und stellt aufgrund ihrer hohen Radiosensitivität das dosislimitierende Organ dar. Es kann zu Nebenwirkungen in Form von akuter Strahlenpneumonitis bis hin zu chronischer Lungenfibrose kommen. Bei diesen Prozessen …
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Adipose tissue transplantation improves metabolic, behavioural and histological parameters in leptin-deficient mice
… leads to the development of steatohepatitis, lung fibrosis and can impair iron metabolism. Daily exogenous subcutaneous leptin injections improve insulin sensitivity and several metabolic abnormalities associated with leptin deficiency in animals and humans, but novel curative and permanent …
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Adipose tissue transplantation improves metabolic, behavioural and histological parameters in leptin-deficient mice
… leads to the development of steatohepatitis, lung fibrosis and can impair iron metabolism. Daily exogenous subcutaneous leptin injections improve insulin sensitivity and several metabolic abnormalities associated with leptin deficiency in animals and humans, but novel curative and permanent …
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