Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"lung epithelium"”.
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Sox2-Dependent Transcriptional Control of Airway Differentiation In The Mouse Lung
<p>The lung is a highly branched tree-like tubular system that results from more than 20 generations of the conducting airways and consists of 300 million alveoli for gas exchange. Airway branches form via branching morphogenesis and then mature into conducting airways, in which the number and …
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Investigating factors governing cell fate decisions in respiratory epithelium
The maintenance of the airway/respiratory epithelium during adult homeostasis and repair and its construction during embryonic development require tightly regulated cell fate decisions. This regulation takes the form of complex transcription factor and signalling cascades, much of which are …
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Extracellular Vesicles to Evaluate the Effects of Mesenchymal Stromal Cells in the Premature Lung
… dysplasia (BPD), caused by disrupted lung development, is a common complication of prematurity without effective treatment. Mesenchymal stromal cells (MSCs) improve features of experimental BPD, such as lung function, structure, and inflammation. The HULC-1 trial assessed the safety of …
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Epidermal growth factor-mediated activation of the unliganded glucocorticoid receptor in A549 cells
… in the regulation of cytokine genes in the lung epithelium fibroblast A549 cell line. Evidence suggests that the EGF-induced repression acts on signalling via the TLR-2 receptor but not via the protein kinase C (PKC) pathway. The EGF response is shown to act via the nuclear factor kappa B …
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Pam2ODN-Induced Epithelial Resistance Against Influenza A Requires STAT3 Activation
… with Pam2ODN only. Furthermore, we challenged lung epithelium-specific STAT3 deletant mice and their floxed littermates with IAV following treatment with PBS or Pam2ODN. We observed here that Pam2ODN-treated STAT3-deletant mice had a significantly lower survival than Pam2ODN-treated floxed …
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Polymeric nanocarriers for the regional and systemic delivery of therapeutics to and through the lungs
<p>The lungs are considered as one of the fastest portals of entry to the bloodstream and oral inhalation (OI) has long been accepted as the preferred mode of administration of therapeutics to the respiratory tract. However, despite its advantages, the lungs have been largely underutilized to …
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The Genome-Wide Roles of The Lung Lineage Transcription Factor Nkx2-1 In The Regulation of Opposing Cell Fates In Vivo
… 2-1 (NKX2-1) is expressed throughout the lung epithelium during development and was thought to be lost in the extraordinarily thin cell type required for gas exchange– the alveolar type 1 (AT1) cell. Complementing precise genetic knockouts with cell type-specific ChIP-seq, ATAC-seq, and …
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The role of N-cadherin and S1P/S1P1 in pancreas development
… of the mesenchyme surrounding the pancreatic epithelium. N-cadherin-deficient embryos expressing N-cadherin or E-cadherin ectopically in the heart rescue dorsal pancreas formation, indicating that the phenotype is secondary to cardio-vascular defects. These results suggest that circulating …
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Differentiation of Normal and Cystic Fibrosis Human Lung Epithelial Cells in a Decellularized and Reconstituted Mouse Lung
Engineered lung tissue may eventually address the chronic shortage of transplantable lung tissue and permit modeling of lung disease in a controlled ex vivo environment. However, there are presently no sources of primary lung stem cells which can be expanded at sufficient scale to permit …
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Investigating The Roles of Lung Epithelial Stat3 In Therapeutically Inducible Resistance to Acute Bacterial Pneumonia.
<p>Investigating the roles of lung epithelial STAT3 in therapeutically inducible resistance to acute bacterial pneumonia.</p> <p>Vikram Vitthal Kulkarni, M.S.</p> <p>Advisory Professor: Scott Evans, MD.</p> <p>The lung epithelium is a dynamic tissue capable of displaying structural and functional …
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Identifying Context-Specific Synthetic Lethal miRNA Inhibition in Non-Small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related fatalities in the US. This is due in part to a lack of highly effective therapies for advanced cases, and this is of special concern as most NSCLC cases are not diagnosed until they are in an advanced, later stage. Recent …
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Effects of Radiation Exposure on Lung Carcinogenesis
Lung cancer is one of the most prevalent forms of cancer in both men and women with over 1.3 million annual related deaths worldwide. Analysis of several human populations exposed to radiation reveals that the lung is remarkably susceptible to the carcinogenic effects of radiation exposure. The …
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A novel role for Sprouty2 in co-ordinating airway and vascular growth of the fetal lung.
… branching and vascular growth in the developing lung are intimately co-ordinated processes which involve cross-talk between the primary inducer of airway tube elongation, Fibroblast Growth Factor 10 (FGF10) and the pro-vasculogenic transcription factor, Hypoxia Inducible Factor 1a (HIF-1a). The …
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Characterizing the Innate Immune Response of Human Airway Cells to the Unique Fungal Allergen Alt a 1
… been shown to enter and be transported through lung epithelium in patient cells. It is hypothesized that transcytosis of allergens like Bet v 1 may contribute to sensitization and exacerbation in atopic individuals. This project was focused on two primary aims; (1) Characterize the innate immune …
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Maturation of pluripotent stem cell-derived alveolar type II cells at air-liquid interface and response to environmental stimuli
… (AT2s) are facultative progenitors of the distal lung epithelium and secrete surfactant, a protein-lipid mixture that lowers alveolar surface tension and prevents alveolar collapse during expiration. AT2s exist at a physiological interface between inhaled air and pulmonary vasculature, and are …
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Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
… patients. Generation of mature/functional lung cells from iPSCs heavily relies on understanding of human lung development. However, analysis of lung development has largely been based on mouse models. Given the differences between mouse and human lungs in terms of size, cell types and gene …
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Hypoxia signalling regulates human lung epithelial cell fates
… whether and how hypoxia directly affects human lung epithelial development. In this PhD thesis, I present my investigation of the effects of chronic hypoxia on the human lung epithelium using organoid models. Human first-trimester lung epithelial progenitors can be isolated from embryonic and …
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Cellular Ensembles in Alveolar Homeostasis and Repair
<p>Lung epithelium, the lining that covers the inner surface of the respiratory tract, is directly exposed to the environment and thus susceptible to airborne toxins, irritants, and pathogen-induced damages. In adult mammalian lungs, epithelial cells are generally quiescent but can respond rapidly …
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Effects of hypercapnic acidosis on the primary cells relevant to acute respiratory distress syndrome pathophysiology and the therapeutic potential of Mesenchymal Stem Cells
… effects of MSCs on repair of the distal lung epithelium, revealing a novel mechanism for the effects of MSCs in ARDS.<br/>