Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"lung epithelial cells"”.
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Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells
… (BMP) signalling is essential for correct lung development where it mediates lung branching morphogenesis. In the adult lung, the BMP pathway is activated during airway inflammation. However, a role for activated BMP signalling has not yet been elucidated. The aims of this project were to …
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MUTAGENIC EFFECTS OF CHROMIUM (IV) ON HUMAN ENDOTHELIAL AND LUNG EPITHELIAL CELLS
… on human umbilical vein endothelial cells (HUVEC) and human bronchial epithelial cells (BEAS-2B) were investigated through morphological, cell viability, gene expression, and cDNA sequencing assays. The cell morphology showed both HUVEC and BEAS-2B cells suffered significant but …
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Differential proteome analysis of human lung epithelial cells following exposure to aromatic volatile organic compounds
… VOC-mediated molecular effects on human lung cells in vitro at VOC concentrations comparable to exposure scenarios below current occupational limits. Although differential expression of single proteins in response to VOCs has been reported, effects on complex protein networks (proteome) …
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Cattle feedlot dust: Solubility in lung simulant fluid and stimulation of cytokine release from lung epithelial cells
… to inducing inflammatory changes in the lung. We did extensive literature searches to understand the mechanism of dust toxicity in respiratory system. This lead to focusing on solubility of dust in lung simulant fluid, and in-vitro study of release of two common biomarkers of inflammatory …
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Differentiation of Normal and Cystic Fibrosis Human Lung Epithelial Cells in a Decellularized and Reconstituted Mouse Lung
Engineered lung tissue may eventually address the chronic shortage of transplantable lung tissue and permit modeling of lung disease in a controlled ex vivo environment. However, there are presently no sources of primary lung stem cells which can be expanded at sufficient scale to permit …
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Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
… IP-10 by LTD4 stimulation via CysLTR1 in human lung epithelial A549 cells. METHOD: To investigate the effect of LTD4 and CysLTR1 on MCP-1 and IP-10, Two different kinds of epithelial cells, A549 cells and CysLTR1 over-expressed A549 cells, were prepared and treated with LTD4 100nM for 0.5, 1, 2, …
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Loss of Gprc5A Enhances Survival In Normal and Malignant Lung Epithelial Cells By Eliciting Persistent Stat3 Activation Induced By Autocrine Lif
… C, group 5, member a (Gprc5a) gene develop lung tumors indicating that Gprc5a is a tumor suppressor. In the present study, we examined he mechanism of Gprc5a-mediated tumor suppression. We found that epithelial cells from <em>Gprc5a</em> knockout mouse lung (<em>Gprc5a</em><sup>-/-</sup> …
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Immune activation at the lung epithelial barrier
Dendritic cells (DCs) are commonly known as the most potent antigen presenting cells in several inflammatory diseases. In the lung the main function of DCs is to sample incoming antigens, transport them to the draining lymph nodes, where they will activate naïve T cells to become effector T cells …
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REPROGRAMMING LUNG FIBROBLASTS INTO LUNG PROGENITORS
… characterized by the replacement of functional lung parenchyma with fibrotic tissue. PF develops due to chronic injury to the lungs, and leads to decreased lung compliance, function and a significant reduction in the quality of life for the patient. Currently, there are no treatments available …
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Influenza A Virus PB1-F2 Protein: its Role in Pathogenesis
… PB1-F2 expression did not affect nasal shedding, lung viral load, immunophenotypes, and lung pathology in pigs. On the other hand, in turkeys, deletion of PB1-F2 resulted in early induction of clinical disease and effective transmission among the turkey poults. Interestingly, the virulence …
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Synthesis and biological research of the pseudomonas aeruginosa signaling compounds PQS and N-3-oxo-dodecanoyl-L-homoserine lactone
… aeruginosa infection. Cultured human A549 lung epithelial cells were taken as a model for the study of an invitro cystic fibrosis type infection, where the change in genetic transcription could be easily determined. The presence of cytokines produced during Pseudomonas aeruginosa infections …
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Nrf2-Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer, Especially Squamous Cell Carcinoma
… 12 A. Localization of Prx III and Srx in A549 cells 12 B. Oxidation of Prx III in mink lung epithelial cells 12 C. Srx dependent regulation of Prx III oxidation in A549 cells 15 D. Srx is translocated into the mitochondria under oxidative stress 15 E. Overexpression of Prx I and III isoforms in …
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Identification and Characterization of LYSMD3, A Novel Epithelial Cell Pattern Recognition Receptor for Chitin
… enigmatic at best. The principal receptor(s) on epithelial cells for chitin recognition remain to be determined. In this study, we demonstrate that LYSMD3 is expressed on the surface of human airway epithelial cells. Interestingly, LYSMD3 is able to bind chitin and β-glucan as well as fungal …
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Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
… oncogene that is overexpressed in non-small cell lung cancer (NSCLC) cells and mediates their proliferation, transformation and tumorigenesis. However, the molecular mechanism underlying TAZ-induced tumorigenesis remains largely unknown. In this study, we first established an in vivo xenograft …
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Losartan, an angiotensin II receptor blocker, fails to attenuate pulmonary dysfunction in ovine burn and smoke model
Elevated levels of angiotensin II (AngII) in the lung have been shown in response to burn and smoke inhalation injury. AngII has been associated with increased nitric oxide levels, leading to nuclear oxidative damage in Type II lung epithelial cells. Losartan is an AngII, AT1A specific receptor …
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The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
… of in vitro studies and an in vivo model of lung disease, namely, bleomycin induced pulmonary fibrosis. Firstly MSC expansion of Treg cells was shown to be dependent on Jagged 1 signalling. MSC inhibition of DC maturation and antigen presentation was shown to also involve Jagged 1 however …
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The Role of the Alternaria Secondary Metabolite Alternariol in Inflammation
… synthases (PKS) in immune responses of lung epithelial cells.
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Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… infections are often complicated by chronic lung pathologies, such as asthma induction, progression, and exacerbation. We have reported that mice treated with a combination of inhaled Toll-like receptor (TLR) 2/6 and TLR 9 agonists (Pam2-ODN) to stimulate innate immunity are broadly protected …
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Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… infections are often complicated by chronic lung pathologies, such as asthma induction, progression, and exacerbation. We have reported that mice treated with a combination of inhaled Toll-like receptor (TLR) 2/6 and TLR 9 agonists (Pam2-ODN) to stimulate innate immunity are broadly protected …
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