Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"lung diseases"”.
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Deep learning for identifying Lung Diseases
<p>Growing health problems, such as lung diseases, especially for children and the elderly, require better diagnostic methods, such as computer-based solutions, and it is crucial to detect and treat these problems early. The purpose of this article is to design and implement a new computer …
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PERINATAL CELLS AS A TREATMENT FOR INFLAMMATORY LUNG DISEASES
… (ARDS). Often, patients with inflammatory lung disease exhibit increased immune cell counts in their lungs such as neutrophils, macrophages and T cells accompanied by elevated levels of pro-inflammatory cytokines such as IFN-γ, IL-6, IL-8, IL-1β and neutrophil elastase (NE). Increased …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
Inflammation occurs in many chronic lung diseases including pulmonary arterial hypertension (PAH) and asthma, however, the mechanisms underlying these diseases are not well understood. This thesis reports the findings from two studies that examined the role of the bone morphogenetic protein type II …
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RESPIRABLE SIRNA TARGETING AT THE NF-KB PATHWAY PROTECTS AGAINST INFLAMMATORY LUNG DISEASES
… disease (COPD) are common inflammatory pulmonary diseases. Cumulative evidences have shown the role of NF-kB signaling pathway in the pathogenesis of asthma and COPD. Ribosomal protein S3 (RPS3) is a subunit of NF-kB complex while receptor-interacting protein 2 (Rip2) is a positive upstream …
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Systems biology of lung diseases: a multi-perspective view from host and pathogen
"Lung diseases include some of the most widespread and deadly conditions known to affect people around the world. The challenges of clinically tackling lung diseases arise from multiple factors associated with both diagnosis and treatment strategies. In my thesis work, I addressed the challenges of …
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Osteopontin and Cadherin 11 Are Novel Mediators and Drug Targets For Chronic Lung Diseases
Chronic lung diseases (CLDs) are a considerable source of morbidity and mortality and are thought to arise from dysregulation of normal wound healing processes. An aggressive, feature of many CLDs is pulmonary fibrosis (PF) and is characterized by excess deposition of extracellular matrix (ECM) …
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Investigation of efficacy and mechanisms of action in mesenchymal stromal cell therapy for chronic lung diseases
… for the treatment of inflammatory and fibrotic lung diseases, specifically Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF). In vitro characterisation of MSC demonstrated significant cytoprotective and reparative effects, through inhibition of epithelial …
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The Therapeutic Potential of Natural Products from <i>Vaccinium</i> Berries for Viral and Lung Diseases Through an Improved LC-MS-Based Chemometric Approach
… rate among teenage girls. Consequently, chronic diseases affected by smoking, such as chronic obstructive pulmonary disorder (COPD), have been increasing there in the last five years. Poland, on the other hand, is an exemplary outlier for the region with much lower smoking prevalence rates and …
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To evaluate the role of miRNAs as potential diagnostic and prognostic biomarkers for Asbestos-related interstitial lung diseases (ILD), Non-Small Cell Lung Cancer (NSCLC) and Malignant Pleural Mesothelioma (MPM)
… cancer mortality worldwide. Asbestos-related lung cancer (LC) and malignant pleural mesothelioma (MPM) prognosis is still poor especially at advanced stage, which highlights the need for early diagnosis and effective biomarkers capable of detecting these diseases at early, potentially …
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Lung disease diagnosis from gene expression profiles
Lung diseases include some of the most widespread and deadly conditions known to affect people in the US today. One of the main challenges in treating lung disease is the difficulty of diagnosis. Clinical diagnosis remains largely dependent upon symptomatic-based diagnoses; many cases can be either …
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Chemokinrezeptorexpression auf T-Zellen in bronchoalveolärer Lavage und peripherem Blut bei Kindern mit chronischer Bronchitis und interstitiellen Lungenerkrankungen
… that selected T cells accumulate in inflammatory lung diseases involving different pulmonary compartments. To test this hypothesis the frequencies of chemokine receptor expressing T cells were compared in peripheral blood (PB) and bronchoalveolar lavage fluid (BALF) of children with chronic …
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Quantification of Pulmonary Ventilation using Hyperpolarized 3He Magnetic Resonance Imaging
Smoking-related lung diseases including chronic obstructive pulmonary disease (COPD) and lung cancer are projected to have claimed the lives of more than 30,000 Canadians in 2010. The poor prognosis and lack of new treatment options for lung diseases associated with smoking are largely due to the …
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Fibroblasts as matrix modulating cells in asthma and COPD
Chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are two lung diseases that are continuously increasing worldwide. Despite extensively research to find curative treatment, no so such therapy exists today. New hypothesis suggests that an aberrant chronic wound …
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Mapping and modeling macrophages in tuberculosis
… and their dynamics in tuberculosis and lung diseases more broadly. We first characterize the single-cell transcriptomic profiles of macrophages within tuberculosis granulomas from non-human primates. We introduce and apply a framework for identifying possible signaling cues contributing …
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Computer Techniques in Analysing Human Adventitious Lung Sounds
… techniques to analyse human adventitious lung sounds, which are distinct sound patterns superimposed onto the normal breath sound and are indicative of certain lung diseases. A software program is written which, upon analysing the acoustic data by several signal processing methods, will …
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Application of a TGA Method to Estimate Coal, Carbonate, and Non-carbonate Mineral Fractions as a Proxy for the Major Sources of Respirable Coal Mine Dust
… to the development of chronic and irreversible lung diseases, such as Coal Worker's Pneumoconiosis (CWP) and Progressive Massive fibrosis (PMF). After the passage of the Federal Coal Mine Health and Safety Act (CMHSA) in the late 1960's the prevalence of CWP among US coal miners decreased. …
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
Chronic lung diseases and acute lung injuries are two distinctive pulmonary disorders that result in significant morbidity and mortality. Adenosine is a signaling nucleoside generated in response to injury and can serve both protective and destructive functions in tissues and cells through …
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Classification of Auscultation Sounds Using a Smart System
Respiratory diseases are a leading cause of death worldwide. Despite modern medicine, treatment of lung diseases is limited by the tools available to diagnose these disorders, especially in low resource settings. While tools such as chest x-ray and CT scans are highly accurate, their high cost …
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Monocyte adherence to fibronectin: role of CD11/CD18 integrins and relationship to other monocyte functions
… to extracellular matrix in inflammatory lung diseases, the adherence properties of monocytes from patients with an inflammatory lung disease (bronchiectasis) and healthy subjects to a representative matrix component (fibronectin) were compared. Spontaneous adherence of monocytes from the …
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Development of an in vitro human lung organoid system to study alveolar type 2 stem cell maintenance and dysfunction during disease
The human adult distal lung parenchyma is maintained by alveolar type 2 (hAT2) cells that have the ability to self-renew and differentiate into alveolar type 1 (hAT1) cells, a critical cell type involved in gas-exchange. Cellular damage within the alveoli can lead to severe lung dysfunction, and …
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