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Showing 1 to 20 of 31 for “"lung development"”.

  1. Roles of MicroRNAs in Fetal Lung Development

    Guo, Wei2018

    Lung alveolar type II cells uniquely synthesize surfactant, a developmentally-regulated lipoprotein that is essential for breathing. Expression of the major surfactant protein, SP-A, in midgestation human fetal lung (HFL) is dramatically induced by cAMP. cAMP induction of SP-A expression is …

    utswmed Repository record

  2. Role of selenium in neonatal lung development

    Kim, Hye YoungUniversity of Illinois at Urbana-Champaign2011

    … to assess the role of dietary selenium (Se) in development of neonatal lungs under normoxia and hyperoxia. Lung development was assessed by measuring certain parameters of functional and structural development, including pulmonary phospholipids and histomorphometry. Lung lesions due to hyperoxia …

    uiuc Repository record

  3. An investigation into the effect of maternal exposure to nicotine and copper on neonatal lung development

    Windvogel, Shantal LynnUniversity of the Western Cape2006

    … (1mg/kg BW/day) during all the phases of lung development, or from the onset of the phase of rapid alveolarisation and, 2) whether copper supplementation (1mg/kg BW/day) will prevent the adverse effects of maternal nicotine exposure, on lung development in the offspring. The latter aim is …

    western-cape Repository record

  4. Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function

    Sun, DaweiUniversity of Cambridge2020

    … patients. Generation of mature/functional lung cells from iPSCs heavily relies on understanding of human lung development. However, analysis of lung development has largely been based on mouse models. Given the differences between mouse and human lungs in terms of size, cell types and gene …

    cambridge Repository record

  5. Studying the Effect of TBX4 Loss-of-Function on Postnatal Lung Development and How it Predisposes to Pulmonary Hypertension

    Maldonado Velez, Gabriel2024

    … to group 3 PH, also known as PH due to chronic lung disease or hypoxia. Heterozygous pathogenic variants within TBX4 have been reported in cases from both PH groups. Therefore, the diagnosis and classification of PH in patients with TBX4 mutations may be more challenging due to its contributions …

    iupui Repository record

  6. Effects of 5-Lipoxygenase Activating Protein Inhibitor on Abnormal Alveolarization and Lung Development Induced by 85% Oxygen Exposure in Newborn Mice Model

    박, 민수2011

    배경: 미숙아에서 발병하는 기관지폐이형성증은 만성적인 호흡곤란과 산소의존도를 나타내는 질환으로서 인공환기요법, 고농도산소, 감염, 영양결핍, 수액과다공급 등의 다양한 원인으로 인한 염증성 반응과 비정상적 폐포화 과정 및 폐포 생성의 감소를 일으키는 것으로 알려져 있다. 최근 동물실험 연구에 의하면 신생 랫드에서 고농도 산소를 투여한 경우 비정상적 폐포생성을 초래하는데 이 과정에 leukotriene이 관여하는 것으로 보고되고 있다. 또한 치사 농도 이하의 농도인 85% 산소에 노출된 신생 마우스에서도 비정상적인 폐포화 현상이 …

    ajou Repository record

  7. Investigating WNT signalling in the lung

    Aravindan, RaaghaviUniversity of Wolverhampton2025

    … by cystic kidney disease, liver fibrosis, and lung failure. The most severe cases of ARPKD have been observed in neonatal life, with a mortality rate of 30–40%, where the cause of death has been attributed to respiratory distress resulting from lung hypoplasia. If this stage is survived, the …

    wlv Repository record

  8. REPROGRAMMING LUNG FIBROBLASTS INTO LUNG PROGENITORS

    Kidiyoor, AmrithaWake Forest University2018

    … characterized by the replacement of functional lung parenchyma with fibrotic tissue. PF develops due to chronic injury to the lungs, and leads to decreased lung compliance, function and a significant reduction in the quality of life for the patient. Currently, there are no treatments available …

    wfu Repository record

  9. Premature aging of the lungs of the offspring induced by maternal nicotine exposure during gestation and lactation: protective effects of tomato juice

    Mutemwa, MuyundaUniversity of the Western Cape2012

    … the interference with normal fetal and neonatal lung development. Maternal cigarette smoke or nicotine exposure produces adverse effects in the lungs of offspring, these include; intrauterine growth retardation, low birth weight, premature birth, reduced pulmonary function at birth, and a high …

    western-cape Repository record

  10. Impact of mechanical signals on human foetal lung cell differentiation

    Sokleva, VanesaUniversity of Cambridge2022

    A major function of the lung is as a mechanical pump to bring oxygen-rich air into the body, allow gas exchange to occur, and remove carbon dioxide-rich air. It is increasingly recognized that physical forces, such as tension, compression, or shear, as well as passive mechanical material properties …

    cambridge Repository record

  11. Investigating factors governing cell fate decisions in respiratory epithelium

    Johnson, Jo-AnneUniversity of Cambridge2018

    … and repair and its construction during embryonic development require tightly regulated cell fate decisions. This regulation takes the form of complex transcription factor and signalling cascades, much of which are unknown, particularly in human lung development. Multiciliogenesis describes the …

    cambridge Repository record

  12. Extracellular Vesicles to Evaluate the Effects of Mesenchymal Stromal Cells in the Premature Lung

    Green, MairéadUniversité d'Ottawa / University of Ottawa2025

    … dysplasia (BPD), caused by disrupted lung development, is a common complication of prematurity without effective treatment. Mesenchymal stromal cells (MSCs) improve features of experimental BPD, such as lung function, structure, and inflammation. The HULC-1 trial assessed the safety of …

    ottawa-retro Repository record

  13. Does maternal nicotine exposure during gestation and lactation change the oxidant-antioxidant status of the lungs of the offsprings and is tomato juice protecting the lungs of the offsprings?

    Abdulkarim, Kayigire XavierUniversity of the Western Cape2009

    … causes diverse effects on fetal and neonatal lung development, integrity and maturation which compromise the gas exchange function of the lungs and renders this vital organ susceptible to gradual damage and different diseases in latter life. Maternal nicotine exposure during gestation and …

    western-cape Repository record

  14. The Effects of Tracheal Occlusion on Wnt Signaling in a Rabbit Model of Congenital Diaphragmatic Hernia

    Mudri, Martina MThe University of Western Ontario2018

    … on epithelial-mesenchymal transition (EMT) in lung development remains poorly understood. The purpose of this study was to a) confirm the CDH rabbit model produced PH which was reversed by TO and b) determine the effects of CDH +/- TO on EMT pathways. Methods: CDH was created at 23 days, TO at …

    uwo Repository record

  15. Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD

    Rose-Zerilli, Matthew J.J.University of Southampton2010

    … associated with increased risk of asthma, poor lung function in adults and COPD in old age. Exposure to oxidative stress and poor nutrition in utero is thought to cause damage to the lung and alter the normal course of lung development.<br/><br/>Glutathione S-transferases (GST) are potent …

    soton Repository record

  16. Investigating The Role of The P63 Isoform Δnp63 In Lung Stem Cell Populations and Lung Cancer

    Wu, Sarah J, <p>https://orcid.org/0000-0003-1755-6454</p>2021

    … studies have determined separate populations of lung progenitor cells that give rise to lung adenocarcinoma and squamous cell carcinoma. ΔNp63 is known to regulate lung development but its role in lung cancer progression remains unclear. We utilized a ΔNp63-specific conditional knockout mouse …

    uthsc Repository record

  17. Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells

    Molloy, Emer LouiseNational University of Ireland Maynooth2008

    … (BMP) signalling is essential for correct lung development where it mediates lung branching morphogenesis. In the adult lung, the BMP pathway is activated during airway inflammation. However, a role for activated BMP signalling has not yet been elucidated. The aims of this project were to …

    maynooth Repository record

  18. The Roles of EGFR and FGFR2 in Cell Shape Maintenance of Human Lung Tip Progenitor Epithelial Cells

    Liu, ShuyuUniversity of Cambridge2022

    … and FGFR2 in Cell Shape Maintenance of Human Lung Tip Progenitor Epithelial Cells Recent work in the developing human lung has identified distal tip epithelial progenitors that are SOX9+SOX2+ and give rise to all lung epithelial cell types (Danopoulos et al., 2019b; Miller et al., 2018; …

    cambridge Repository record

  19. Characterizing The Recognition Motif and Novel Substrates of Carm1

    gayatri, Sitaram2019

    … identical hyper-proliferation defects during lung development, suggesting a genetic link between NFIB and CARM1. NFIB can both activate and repress transcription, but the mechanism is unknown. Here, we show that CARM1 functions as a transcriptional regulator for NFIB targets, suggesting that …

    uthsc Repository record

  20. Effects of early weaning on finishing feed efficiency, marbling development and retail product quality of beef steers

    Smith, Jason KalebVirginia Tech2015

    … weaning on finishing feed efficiency, marbling development and retail product quality of beef steers. In experiment I, which included 90 Angus-sired steers from four calving seasons, early weaning followed by a short ad libitum concentrate-feeding and pasture-backgrounding phase reduced …

    vt Repository record

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